Detection of serum collagen type IV in children with type 1 (insulin-dependent) diabetes mellitus - a longitudinal study

Nicoloff, G.; Baydanoff, S; Stanimirova, N.; Petrova, Ch.; Christova, P.

doi:10.1034/j.1399-5448.2001.20408.x

Cited by 12 publications

(7 citation statements)

References 42 publications

(42 reference statements)

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“…Collagen IV is a major matrix protein of the basement membranes, and elevated serum and urine levels have been associated with diabetic microangiopathic complications, especially DN [ 60 – 64 ]. Lee et al [ 59 ] found that plasma levels of 7S-collagen, a collagen IV domain resistant to various proteases, are elevated in DR and DN and that its levels increased with the severity of both diseases.…”

Section: Biomarkers Of Basement Membrane and Extracellular Matrix mentioning

confidence: 99%

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Simó‐Servat

Simó

Hernández

2016

Journal of Diabetes Research

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Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR. Therefore, new pharmacological treatments for these early stages of the disease are required. In order to develop therapeutic strategies for early stages of DR new diagnostic tools are urgently needed. In this regard, circulating biomarkers could be useful to detect early disease, to identify those diabetic patients most prone to progressive worsening who ought to be followed up more often and who could obtain the most benefit from these therapies, and to monitor the effectiveness of new drugs for DR before more advanced DR stages have been reached. Research of biomarkers for DR has been mainly based on the pathogenic mechanism involved in the development of DR (i.e., AGEs, oxidative stress, endothelial dysfunction, inflammation, and proangiogenic factors). This review focuses on circulating biomarkers at both early and advanced stages that could be relevant for the prediction or detection of DR.

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Section: Biomarkers Of Basement Membrane and Extracellular Matrix mentioning

confidence: 99%

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Simó‐Servat

Simó

Hernández

2016

Journal of Diabetes Research

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“…Increased levels of autoantibodies against collagen type IV have been associated with diabetes and development of microangiopathy [14] and have also been reported in patients with systemic vasculitis and Crohn's disease [13], [15]. Moreover, autoantibodies against collagen type IV have been detected in children with type 1 diabetes and hypertension [16], [17].…”

Section: Introductionmentioning

confidence: 97%

Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction

McLeod

Dunér

Samnegård

et al. 2015

IJC Heart & Vasculature

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BackgroundCollagen type IV is the major constituent of basement membranes underlying endothelial cells and is important for endothelial cell attachment and function. Autoantibodies against native collagen type IV have been found in various autoimmune diseases. Oxidation of LDL in the vascular wall results in the formation of reactive aldehydes, which could modify surrounding matrix proteins. Like oxidized LDL, these modified matrix proteins are likely to induce immune responses. We examined whether autoantibodies against native or aldehyde-modified collagen type IV are associated with myocardial infarction.MethodsIgM and IgG against native and aldehyde-modified collagen type IV were measured by ELISA in serum from 387 survivors of a first myocardial infarction and 387 age- and sex-matched controls.ResultsPost-infarction patients had significantly increased levels of IgM against native collagen type IV, and IgG against native collagen type IV was present at detectable level in 17% of patients as opposed to 7% of controls (p < 0.001). Controlling for major cardiovascular risk factors demonstrated that the presence of IgG against native collagen type IV was associated with myocardial infarction (OR 2.9 (1.6–5.4), p = 0.001). Similarly, subjects in the highest quartile of IgM against native collagen type IV had increased risk of having suffered myocardial infarction (OR 3.11 (1.8–5.4), p < 0.001) after adjusting for cardiovascular risk factors. In contrast, IgG against aldehyde-modified collagen type IV was decreased in myocardial infarction patients, but this association was not independent of established cardiovascular risk factors.ConclusionAutoantibodies against collagen type IV are associated with myocardial infarction independently of traditional cardiovascular risk factors.

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“…On the other hand, an important factor for the development of diabetic vascular complications is the alteration in the structure of the vascular proteins. Peptides derived from such processes have been found in the circulation (Nicoloff et al, 2000a(Nicoloff et al, , 2001 and they are reasoned to be a stimulus for increased production of autoantibodies. A variety of autoantibodies have been documented in diabetes and include insulin autoantibodies, GAD-autoantibodies, tyrosine phosphatase IA2-autoantibodies, islet cell-autoantibodies, (Verge et al, 1998) elastin autoantibodies (Nicoloff et al, 2000b) and collagen type IV autoantibodies (Nicoloff et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Circulating Immune Complexes among Diabetic Children

Nicoloff

Blazhev

Petrova³

et al. 2004

Journal of Immunology Research

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Insulin dependent diabetes mellitus (IDDM) is an autoimmune disease associated with the presence of different types of autoantibodies. The presence of these antibodies and the corresponding antigens in the circulation leads to the formation of circulating immune complexes (CIC). CIC are known to persist in the blood for long periods of time. Such CIC following deposition in the small blood vessels have the potential to lead to microangiopathy with debilitating clinical consequences. The aim of our pilot study was to investigate whether a correlation exists between CIC and the development of microvascular complications in diabetic children. Isolation of a new glycoprotein complement inhibition factor (CIF) from the parasitic plant Cuscuta europea seed, which appears to bind specifically to complement component C3 has provided an unique tool for the measurement of immune complexes by means of ELISA-type techniques (CIF-ELISA). We studied the levels of CIC (IgG, IgM and IgA) in 58 diabetic children (mean age 12.28±4.04 years, diabetes duration 5.3±3.7 years), 29 of them had vascular complications (group 1) and the other 29 were without vascular complications (group 2). As controls, we studied sera samples from 21 healthy children (mean age 13.54±4.03 years). Sera from the diabetic patients showed statistically significant higher levels of CIC IgG ( p=0.03) than sera from the control group. In sera from group 1 values of CIC IgG showed statistically significant higher levels than controls (0.720±0.31 vs. 0.46±0.045; p=0.011) Sera from 59% of the patients were positive for CIC IgG, 36% for CIC IgM and 9% for CIC IgA. Among 26 patients with microalbuminuria, sera from 17/26 (65%) were positive for CIC IgG, 8/26 (31%) for CIC IgM and 2/26 (8%) for CIC IgA. CIC IgG correlated with HbA1c (r=0.51; p=0.005) and microalbuminuria (r=0.42, p=0.033). CIC IgA correlated with age (r=0.44, p=0.03). CIC IgM correlated with the duration of diabetes (r=0.63, p=0.02). These findings suggest that elevated levels of CIC IgG are associated with the development of early diabetic nephropathy.

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Detection of serum collagen type IV in children with type 1 (insulin-dependent) diabetes mellitus - a longitudinal study

Cited by 12 publications

References 42 publications

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction

Circulating Immune Complexes among Diabetic Children

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