2003
DOI: 10.1063/1.1540176
|View full text |Cite
|
Sign up to set email alerts
|

Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications

Abstract: We have fabricated a series of highly sensitive spin valve sensors on a micron scale that successfully detected the presence of a single superparamagnetic bead (Dynabeads M-280, 2.8 μm in diameter), and thus showed suitability for identifying biomolecules labeled by such magnetic beads. By polarizing the magnetic microbead on a spin valve sensor with a dc magnetic field and modulating its magnetization with an orthogonal ac magnetic field, we observed a magnetoresistance (MR) signal reduction caused by the mag… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
90
0

Year Published

2005
2005
2014
2014

Publication Types

Select...
5
4

Relationship

2
7

Authors

Journals

citations
Cited by 203 publications
(91 citation statements)
references
References 6 publications
1
90
0
Order By: Relevance
“…Another significant advance reported here concerns the magnetic and kinetic properties of the MNTs. Magnetic analyte quantification has been demonstrated for DNA detection and has typically required large magnetic labels that range in size from approximately 250 nm to 3 m (11,12,14,21). These m-sized labels are not optimal for biomolecular assays-they diffuse slowly, are prone to magnetic interaction and subsequent precipitation, and are very bulky compared with the analyte molecules.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Another significant advance reported here concerns the magnetic and kinetic properties of the MNTs. Magnetic analyte quantification has been demonstrated for DNA detection and has typically required large magnetic labels that range in size from approximately 250 nm to 3 m (11,12,14,21). These m-sized labels are not optimal for biomolecular assays-they diffuse slowly, are prone to magnetic interaction and subsequent precipitation, and are very bulky compared with the analyte molecules.…”
Section: Discussionmentioning
confidence: 99%
“…By labeling the target analyte of interest with MNTs (see Fig. 1), analyte detection and quantification can occur when the analyte binds to capture probes on the surface of giant magnetoresistive (GMR) sensors (11)(12)(13)(14)(15) such as spin valve (SV) sensors (16), which have been developed and optimized for use in hard disk drives on a scale of hundreds of millions of units annually with great economy and reliability. Such sensors, when modified for use in biological applications, were previously shown to be capable of detecting as few as 10 MNTs (13,16).…”
mentioning
confidence: 99%
“…The detection scheme reported here does not require modulated ac magnetic fields. 6,7 This fact, combined with the micrometer size of the tunnel junction, suggests that this detection method could potentially be scaled into a multianalyte "lab-on-a-chip" detector.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] The magnetic properties of nanoparticles decisively depend on their size, owing to the dependence of their relaxation of magnetization orientation on the particle size. Controlling the size distribution and obtaining the thermal as well as chemical stability of nanoparticles are therefore among the pivotal concerns in an application point of view of these materials.…”
Section: Introductionmentioning
confidence: 99%