Detection of sites of infection in mice using 99mTc-labeled PN2S-PEG conjugated to UBI and 99mTc-UBI: a comparative biodistribution study

Meléndez‐Alafort, Laura; Nadali, Anna; Pasut, Gianfranco; Zangoni, Elena; De, Raffaele; Cariolato, Luca; Giron, Maria Cecilia; Castagliuolo, Ignazio; Veronese, Francesco M.; Mazzi, Ulderico

doi:10.1016/j.nucmedbio.2008.10.011

Cited by 37 publications

(27 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is remarkable since diinsertion processes are incredibly rare. [10] Significantly,t he compounds 4 are an ew family of derivatized phosphinodicarboxamides, and have potential applications in coordination chemistry, [11] supramolecular and self-assembled arrays, [12] biomedicine, [13] and enantioselective catalysis. [14] Initially,P h 2 PH was treated with one equivalent of PhNCO using 5mol %o f1 as the precatalyst ( Table 1, entry 1).…”

Section: Organophosphoruscompoundsareavitalclassofchemicalsmentioning

confidence: 99%

“…When the reaction was performed with nHexNCO,the hydrophosphination competed with the cyclotrimerization reaction, leading to amixture of [nHexNCO] 3 , [9] [Ph 2 PC(=O)N(H)nHex] (3e), and [Ph 2 PC(=O)N(nHex)-C(=O)N(H)nHex] (4e)( Table 1, entries 10-12). Meanwhile, reactions with more sterically encumbered secondary and tertiary isocyanates (CyNCO, iPrNCO,a nd tBuNCO) afforded, almost exclusively,t he monoinsertion products (3f-h;entries [13][14][15][16][17][18][19]. For iPrNCO and tBuNCO the temperature was raised to 60 8 8Ct or each reasonable conversions, within 16 hours (entries [15][16][17][18][19], of around 90 %f or 3g and greater than 70 %f or 3h.P revious attempts by others to catalyze the hydrophosphination of tBuNCO with Ph 2 PH were low yielding (< 20 %).…”

Section: Organophosphoruscompoundsareavitalclassofchemicalsmentioning

confidence: 99%

See 1 more Smart Citation

Iron(II)‐Catalyzed Hydrophosphination of Isocyanates

et al. 2017

View full text Add to dashboard Cite

The first transition metal catalyzedh ydrophosphination of isocyanates is presented. The use of low-coordinate iron(II) precatalysts leads to an unprecedented catalytic double insertion of isocyanates into the P À Hb ond of diphenylphosphine to yield phosphinodicarboxamides [Ph 2 PC(=O)N(R)-C(=O)N(H)R],anew family of derivatized organophosphorus compounds.This remarkable result can be attributed to the low-coordinate nature of the iron(II) centers whose inherent electron deficiency enables aL ewis-acid mechanism in which ac ombination of the steric pocket of the metal center and substrate sizedetermines the reaction products and regioselectivity.Supportinginformation (full experimental details for the hydrophosphination reactions, reaction monitoring by NMR spectroscopy, crystallographic data) and the ORCID identification number(s) for the author(s) of this article can be found under:http://dx.

show abstract

Section: Organophosphoruscompoundsareavitalclassofchemicalsmentioning

confidence: 99%

Section: Organophosphoruscompoundsareavitalclassofchemicalsmentioning

confidence: 99%

Iron(II)‐Catalyzed Hydrophosphination of Isocyanates

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The most explored radiolabeled antibiotics, 99m Tc-ciprofloxacin (Infecton ® ) was intensively debated in the literature due to its drawbacks in practical use [ 48 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. Up-to-date, the synthetic antimicrobial peptide, 99m Tc-UBI 29–41 (fragment of Ubiquicidin) is the most promising probe [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. This probe showed excellent sensitivity, specificity and accuracy to infections (95%) in clinical trials [ 79 ].…”

Section: Diagnostic Imaging Modalitiesmentioning

confidence: 99%

Functional Imaging in Diagnostic of Orthopedic Implant-Associated Infections

Potapova

2013

Diagnostics

View full text Add to dashboard Cite

Surgeries’ sterile conditions and perioperative antibiotic therapies decrease implant associated infections rates significantly. However, up to 10% of orthopedic devices still fail due to infections. An implant infection generates a high socio-economic burden. An early diagnosis of an infection would significantly improve patients’ outcomes. There are numerous clinical tests to diagnose infections. The “Gold Standard” is a microbiological culture, which requires an invasive sampling and lasts up to several weeks. None of the existing tests in clinics alone is sufficient for a conclusive diagnosis of an infection. Meanwhile, there are functional imaging modalities, which hold the promise of a non-invasive, quick, and specific infection diagnostic. This review focuses on orthopedic implant-associated infections, their pathogenicity, diagnosis and functional imaging.

show abstract

“…26 These simple conjugates based on PEG and the chelating agent could only accumulate, and therefore highlight, tissues with an enhanced permeability such as tumors showing the EPR effect. The rational development of these derivatives was the addition of a targeting residue to address a specific cell population or tissue 27…”

Section: The Laboratory’s Contributions To Pegylation Chemistrymentioning

confidence: 99%

Improvement of Drug Therapy by Covalent PEG Conjugation: An Overview From a Research Laboratory

Pasut

Veronese

2010

Israel Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

In the last two decades, efforts focused in the field of drug delivery have made it possible to reach important goals, especially with proteins and peptides. The story of the evolution of this matter is vast and it is difficult to summarize its various aspects in a single review. On the other hand, it could be really interesting to look at the inside story of a typical academic research lab that has dedicated almost all its resources to drug delivery. In our case, an initial interest in the issue of protein conformation stability soon paved the way for a new area of study: the modification of proteins with synthetic polymers. We have seen this technique transformed from a crude and inhomogeneous procedure into a well-recognized and successful approach. This great advance has been possible thanks to the development of dedicated chemical coupling methods and to the better understanding of the behavior of polymers in vivo. In particular, among the several polymers investigated, PEG has became the best polymer for protein modification. Exploiting the unique properties of this polymer, we have conducted several investigations in the field of protein PEGylation and then transferred the acquired know-how to the development of conjugates with low molecular weight drug. This last aspect still presents several unmet needs that are awaiting proper solutions

show abstract

Detection of sites of infection in mice using 99mTc-labeled PN2S-PEG conjugated to UBI and 99mTc-UBI: a comparative biodistribution study

Cited by 37 publications

References 17 publications

Iron(II)‐Catalyzed Hydrophosphination of Isocyanates

Iron(II)‐Catalyzed Hydrophosphination of Isocyanates

Functional Imaging in Diagnostic of Orthopedic Implant-Associated Infections

Improvement of Drug Therapy by Covalent PEG Conjugation: An Overview From a Research Laboratory

Contact Info

Product

Resources

About