Detection of skin alterations in mild-to-moderate chronic venous disease using non-invasive techniques

Paul, Alexis; Braun, C.; Mosnier, Anne; Lavoix, Agnès; Sagorny, Karen; Lefebvre, Tiphaine; Chaigneau, Cyril; Nicolas, Jean-François; Vocanson, Marc; Nosbaum, Audrey

doi:10.1684/ejd.2020.3873

Cited by 1 publication

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paul et al 30 studied how chronic venous disease (CVD), a condition characterized by inflammation secondary to hypertension, may impact skin barrier integrity. They used the Clinical, Etiologic, Anatomic, Pathophysiologic (CEAP) system to stage disease in 34 female participants that were recruited for the study, with C0 representing no disease and C6 representing the most severe progression 30 . TEWL measurements were taken using the Tewameter TM300 at one lesional area near the lateral malleolus and a non‐lesional area 5 cm below the knee on each participant in rooms 22–26°C with humidity from 20%–40% 30 .…”

Section: Resultsmentioning

confidence: 99%

“…They used the Clinical, Etiologic, Anatomic, Pathophysiologic (CEAP) system to stage disease in 34 female participants that were recruited for the study, with C0 representing no disease and C6 representing the most severe progression 30 . TEWL measurements were taken using the Tewameter TM300 at one lesional area near the lateral malleolus and a non‐lesional area 5 cm below the knee on each participant in rooms 22–26°C with humidity from 20%–40% 30 . Results showed an increased TEWL in C2, C3 and C4 participants compared with C0/C1 participants in the lesional area.…”

Section: Resultsmentioning

confidence: 99%

“…29 The only significant finding was that diabetic patients requiring a high insulin dose of >1 U kg −1 day −1 had higher TEWL on the flank areas compared with controls. 29 Paul et al 30 studied how chronic venous disease (CVD), a condition characterized by inflammation secondary to hypertension, may impact skin barrier integrity. They used the Clinical, Etiologic, Anatomic, Pathophysiologic (CEAP) system to stage disease in 34 female participants that were recruited for the study, with C0 representing no disease and C6 representing the most severe progression.…”

Section: Malignancies and Diseasementioning

confidence: 99%

“…30 TEWL measurements were taken using the Tewameter TM300 at one lesional area near the lateral malleolus and a nonlesional area 5 cm below the knee on each participant in rooms 22-26°C with humidity from 20%-40%. 30 Results showed an increased TEWL in C2, C3 and C4 participants compared with C0/C1 participants in the lesional area. However, this same trend was not observed in the non-lesional area.…”

Section: Malignancies and Diseasementioning

confidence: 99%

“…However, this same trend was not observed in the non-lesional area. 30 Coronary artery disease may also disrupt skin barrier integrity in patients, as studied by Öksüm Solak et al 31 Fifty patients diagnosed with coronary artery disease via angiography were compared with 45 healthy volunteers aged 18 years or older. 31 Patients were excluded if they had a history of dermatological conditions that may affect TEWL measurements.…”

Section: Malignancies and Diseasementioning

confidence: 99%

See 4 more Smart Citations

“Normal” TEWL‐how can it be defined? A systematic review

Green

Feschuk

Kashetsky

et al. 2022

Experimental Dermatology

View full text Add to dashboard Cite

An optimal amount of water, especially in the stratum corneum, is essential for maintaining normal functioning, healthy skin. 1 Therefore, the amount of water from the skin is carefully regulated, in part through trans-epidermal water loss. 1 Trans-epidermal water loss (TEWL) is an objective measurement of the amount of water passively evaporating from a designated area of stratum corneum in a fixed amount of time due to the water vapour pressure gradient on either side of the skin. It has historically been used as a measure of barrier water function and skin integrity in healthy individuals. 2 Advantages of using a non-invasive marker of skin integrity such as TEWL include a lack of skin barrier destruction, and the potential for early detection of subclinical effects. 3 Elevated TEWL values may reflect barrier dysfunction in diseases such as atopic dermatitis and psoriasis. 4,5 Oppositely, decreased TEWL values reflect an intact or recovered dermal barrier. 5 Thus, TEWL values are typically measured for in vitro permeation testing (IVPT) to reflect a healthy skin sample, and regulatory agencies such as the Food and Drug Administration (FDA) and European Group for Efficacy

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%