Detection of Small Pancreatic Tumors with Multiphasic Helical CT

Bronstein, Yulia; Loyer, Evelyne M.; Kaur, Harmeet; Choi, Haesun; David, Cynthia L.; DuBrow, Ronelle A.; Broemeling, Lyle D.; Cleary, Karen R.; Charnsangavej, Chusilp

doi:10.2214/ajr.182.3.1820619

Cited by 227 publications

(107 citation statements)

References 12 publications

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“…Tumors, being hypovascular and less dense than the normal pancreas on CT , are best seen in this pancreatic phase (Fig. 7) [20,21]. The pancreatic phase also depicts the arterial anatomy very well.…”

Section: Ctmentioning

confidence: 91%

“…There are several heritable disorders which are associated with an increased incidence of pancreatic ductal adenocarcinoma such as Peutz-Jeghers syndrome (132 times increased risk), hereditary pancreatitis (53 times increased relative risk); familial atypical multiple mole melanoma syndrome (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) times increased risk); familial pancreatic cancer syndrome (9-32 times increased risk) and hereditary breast and ovarian cancer syndrome-BRCA mutation (2-10 times increased risk) [4,5].…”

Section: Epidemiologymentioning

confidence: 99%

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Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Vikram

Balachandran

2010

Indian J Surg Oncol

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Pancreatic cancer is a relatively common malignancy of the gastrointestinal tract for which complete surgical excision remains the only curative option. Being infiltrative in nature and bearing a complex anatomical relationship with various organs, peritoneal ligaments and vascular structures, accurate anatomical staging is key in treatment of these patients. In this article, we will discuss and provide a brief overview of anatomy and use of imaging in staging pancreatic cancer.

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Section: Ctmentioning

confidence: 91%

Section: Epidemiologymentioning

confidence: 99%

Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Vikram

Balachandran

2010

Indian J Surg Oncol

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“…17 The sensitivity of CT in the detection of pancreatic tumors has improved in recent times and lies between 75% and 100% in different series, with a specificity of 70%-100%. [22][23][24][25][26][27][28][29] However, the smaller the tumor is, the less the CT sensitivity. It is reported that CT sensitivity for lesions measuring #2 cm is between 68% and 77% 23,25 and the accuracy close to 77%.…”

Section: Accuracy Of Mdctmentioning

confidence: 99%

“…MDCTA seems to be the technique of choice, permitting detailed evaluation of peripancreatic arteries and veins before therapeutic selection and design, specifically in borderline cases. 5,[11][12][13]16,17,19,21,23,[25][26][27]29,33,[36][37][38][39][40][41]44,45,[48][49][50]52,53,56,57,[63][64][65][66] …”

Section: Publication-based Evidencementioning

confidence: 99%

Value of multidetector computed tomographic angiography in marginally resectable pancreatic cancer

Fagkrezos¹,

Dervenis²,

Triantopoulou³

2015

RMI

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Background: Pancreatic carcinoma is a common gastrointestinal malignancy. Accurate preoperative imaging helps to avoid unnecessary or unsuccessful surgical procedures and reduce the number of aborted pancreatic resections. The purpose of this review is to determine the role of multidetector computed tomographic angiography (MDCTA), which allows rapid anatomic evaluation, in accurate local and distant staging of marginally resectable pancreatic adenocarcinomas. Methods: Our methodology was based on the systematic search of published papers using PubMed/MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for the years 2009-2014, reporting on the reliability and diagnostic accuracy of MDCTA in the evaluation of pancreatic cancer resectability. Results: Based on 33 articles analyzed in the review, MDCTA is the most widely available imaging modality for diagnosing and staging patients with pancreatic cancer, and it can be used for the surgical planning, specifically in locally advanced marginally resectable tumors. Conclusion: Accurate pretreatment assessment of resectability is crucial to design appropriate preoperative protocols of the operating team. It is possible to achieve a complete resection at the first instance in some patients who have borderline resectable tumors as predicted on preoperative imaging. Preoperative MDCTA-based grading systems can help identify such patients. This would help to avoid delayed curative resections in such patients and minimize the risk of aborted open-close operations.

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“…Although the sensitivity and accuracy of MDCT and MRI in diagnosis of pancreatic cancer have been improved significantly, it is still difficult to diagnosis at an early stage (Bronstein et al 2004;Kartalis et al 2009). The sensitivities and specificities were reported as 73%-94% and 95% for CT (DelMaschio et al 1991;Koito et al 1997), 85% and 96% for MRI (Ichikawa et al 2001).…”

mentioning

confidence: 99%

Combined Imaging with Multi-Detector Row Computed Tomography and Diffusion-Weighted Imaging in the Detection of Pancreatic Cancer

Yasui¹,

Sato²

2011

Tohoku J. Exp. Med.

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Pancreatic cancer is one of the most aggressive malignant tumor types. Its prognosis is extremely poor without early detection, and an accurate diagnosis with imaging techniques is vital for any chance of long-term survival after treatment. Despite the great technical advances that have been made with various kinds of imaging equipment, detection of pancreatic cancer is unsatisfactory, and new modalities are required. Diffusion-weighted imaging (DWI) on magnetic resonance imaging (MRI) has high sensitivity and specificity for the detection of pancreatic cancer; however, it does not provide anatomic information. Quite often, the necessary spatial correlation of a high-intensity area with anatomic structures is constrained. If it becomes possible to combine the imaging technique of DWI with multi-detector row computed tomography (MDCT), such as is done with positron emission tomography (PET) and computed tomography (CT), it is expected that the early diagnostic capability will improve. The objective of this study was to introduce combined imaging with DWI and CT into clinical practice to improve the diagnosis of pancreatic cancer. In the current report, we demonstrate a clinical attempt to combine DWI on MRI with the anatomical accuracy of MDCT for two patients of pancreatic adenocarcinoma. Analysis of these two patients revealed that the combined images corresponded precisely to the operative findings. Thus, the combined imaging with DWI and MDCT is useful for the detection of the pancreatic cancer.

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Detection of Small Pancreatic Tumors with Multiphasic Helical CT

Cited by 227 publications

References 12 publications

Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Imaging in Staging and Management of Pancreatic Ductal Adenocarcinoma

Value of multidetector computed tomographic angiography in marginally resectable pancreatic cancer

Combined Imaging with Multi-Detector Row Computed Tomography and Diffusion-Weighted Imaging in the Detection of Pancreatic Cancer

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