“…On the other hand, unsupervised segmentation consists of partitioning the image into a set of regions which are distinct and uniform with respect to specific properties, such as gray level, texture or color. Supervised approaches to mass detection are usually based on a template matching scheme, 17,18 the extraction and classification of a set of features, 19,20 the detection of spicules radiating from a central mass, [21][22][23] the creation of a statistical model of the mass, 23,24 or more recently the use of neural networks. 25,26 On the other hand, unsupervised approaches are based on an initial rough segmentation to detect regions of interest ͑ROIs͒, 27,28 which are regions likely to contain a mass, and subsequently, another algorithm, typically snakes, is used to refine the initial boundary.…”