Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats

Szűcs, Kálmán Ferenc; Grosz, György; Süle, Miklós; Sztojkov‐Ivanov, Anita; Ducza, Eszter; Márki, Árpád; Kothencz, Anna; Balogh, László; Gáspár, Róbert

doi:10.1016/j.lfs.2018.05.015

Cited by 8 publications

(8 citation statements)

References 27 publications

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“…Significant increase of the myoelectric power was found on the small intestinal pattern after a diet with increased amount of fibre [ 29 ]. Group of Robert Gáspár [ 30 ] used electromyography to record slow-waves myoelectric signals of the stomach, small intestine and large bowel to study stress-induced gastrointestinal dysmotility changes in awake rats. This study enabled to assess gastrointestinal changes as a consequence of dysregulation in the gut-brain axis.…”

Section: Discussionmentioning

confidence: 99%

The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

Tsianou,

Kvetina,

Radochova

et al. 2023

PLoS ONE

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Background Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer’s disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clinical use. The aim of this study was to assess the impact of rivastigmine on gastric motor function by means of electrogastrography (EGG) in experimental pigs. Methods Six experimental adult female pigs (Sus scrofa f. domestica, hybrids of Czech White and Landrace breeds; 3-month-old; mean weight 30.7 ± 1.2 kg) were enrolled into the study twice and created two experimental groups. In group A, a single intragastric dose of 6 mg rivastigmine hydrogen tartate was administered in the morning to fasting pigs before EGG recording. In group B, rivastigmine was administered to overnight fasting animals in a dietary bolus in the morning for 7 days (6 mg per day). On day 8, an intragastric dose of 12 mg rivastigmine was given in the morning to fasting pigs before EGG. EGG recording was accomplished by means of an EGG standalone system. Recordings from both groups were evaluated in dominant frequency and EGG power (areas of amplitudes). Results In total, 1,980 one-minute EGG intervals were evaluated. In group A, basal EGG power (median 1290.5; interquartile range 736.5–2330 μV2) was significantly higher in comparison with the power of intervals T6 (882; 577–1375; p = 0.001) and T10 (992.5; 385–2859; p = 0.032). In group B, the dominant frequency increased significantly from basal values (1.97 ± 1.57 cycles per minute) to intervals T9 (3.26 ± 2.16; p < 0.001) and T10 (2.14 ± 1.16; p = 0.012), respectively. In group B, basal EGG power (median 1030.5; interquartile range 549–5093) was significantly higher in comparison with the power of intervals T7 (692.5; 434–1476; p = 0.002) and T8 (799; 435–1463 μV2; p = 0.004). Conclusions Both single as well as repeated intragastric administration of rivastigmine hydrogen tartrate caused a significant decrease of EGG power (areas of amplitudes) in experimental pigs. EGG power may serve as an indirect indicator of gastric motor competence. These findings might provide a possible explanation of rivastigmine-associated dyspepsia in humans.

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Section: Discussionmentioning

confidence: 99%

The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

Tsianou,

Kvetina,

Radochova

et al. 2023

PLoS ONE

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“…"Based on these findings, they concluded that the neurotic personality of athletes could influence their cognitive and physiological responses in a competition" (BALYAN et al, 2016). Szűcs et al (2018) the effects of stress on the central nervous system and gastrointestinal smooth muscle depressants electromyography detected in rats. In the functional gastrointestinal (GI) tract, slow-wave myoelectric signals can be detected by electromyography (EMG).…”

Section: Objective Measurementsmentioning

confidence: 99%

The Relationship Between Arousal Zone, Anxiety, Stress and Sports Performance

Németh

Balogh

2021

Stadium

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This study aimed to examine the relationship between optimal functioning zone, anxiety, stress, and athletic performance. We conducted a systematic review of the available scientific articles and publications. Related literature was analyzed, relevant, or helpful in understanding the psychological aspects of athletic performance. It discusses the method and validity of hypotheses and approaches that have already appeared scientifically. We examined multidimensional approaches, which discuss the suitability and implications of some recent and more complex models of stress and performance. We may conclude that the relationship between stress and athletic performance is multidimensional. We also examined several factors, such as the interaction between the nature of the stressor, the cognitive needs of the task, and the individuals' psychological characteristics. Both physical and mental preparation is critical to successful sports performance. This way, the level of physical skills, mental preparedness significantly determine overall athletic performance. The article aims to provide a historical overview of the implementation, testing, and measurement of IZOF and other applied models.

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“…The changes in the myoelectric activity of the GIT were followed with SMEMG in parallel with the mechanical contractions in anaesthetised rats using a strain gauge tool. Another SMEMG experiment was carried out in awake rats, measuring GIT activity under normal and stressed conditions [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive smooth muscle electromyography (SMEMG) as a novel monitoring technology of the gastrointestinal tract of awake, free-moving pigs—A pilot study

Nagy¹,

Fébel²,

Bázár³

et al. 2021

PLoS ONE

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There are several mathematical models and measurements to determine the efficiency of the digestibility of different feedstuffs. However, there is lack of information regarding the direct methods or measurement techniques used to analyse the physical response of the different parts of the gastrointestinal tract (GIT) of growing pigs to different diets. Smooth muscle electromyography (SMEMG) is a non-invasive method for the measurement of gastrointestinal myoelectrical activity. In the present study, SMEMG methodology has been adapted from laboratory rats to pigs, and the effects of feedstuffs with control (CTR) or experimentally increased (EXP) amounts of fibre were investigated on gastrointestinal tract motility. Nine barrow pigs ((Danish Landrace × Danish Yorkshire) × Danish Duroc) were used (30 ± 3 kg), and their CTR and EXP feedstuffs contained 29 and 49 g/kg crude fibre (CF), respectively. Myoelectric activities of the stomach, ileum and caecum were detected in the awake pigs by a pair of electrodes. The recorded myoelectric signals were analysed with fast Fourier transformation (FFT), and the spectra were expressed in GIT section-specific cycles per minutes (cpm) values and the maximum power spectrum density (PsDmax). A significant increase (P < 0.001) was observed in the value of the PsDmax of the small intestine (20–25 cpm) as a consequence of the EXP diet. The PsDmax values of the stomach (3–5 cpm) and large intestine (1–3 cpm) did not show any significant change in pigs fed the EXP diet. As a direct and non-invasive method, SMEMG is suitable for the rapid evaluation of the effects of diets with different fibre contents on the GIT of non-anaesthetised, free-moving pigs.

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Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats

Cited by 8 publications

References 27 publications

The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs

The Relationship Between Arousal Zone, Anxiety, Stress and Sports Performance

Non-invasive smooth muscle electromyography (SMEMG) as a novel monitoring technology of the gastrointestinal tract of awake, free-moving pigs—A pilot study

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