Detection of the oxidation products of thiols: Disulfides, and sulfenic, sulfinic, and sulfonic acids

Synthesis of Naphthalimide Azocarboxylates Showing Turn‐On Fluorescence by Substitution Reaction with Sulfinates**

“…On the other hand, target labeling in chemical biology requires the formation of covalent bonds with the appropriate labeling molecules for post‐labeling analysis, such as proteomics. However, efficient labeling methods for sulfinates are still under development due to their weak nucleophilicity and electrophilicity compared to other sulfur functional groups such as sulfanyl (R‐SH) and sulfenyl (R‐SOH) groups [9,10] . For this reason, to date, highly electrophilic functional groups have proven effective in capturing sulfinates, with nitroso compounds (aryl nitroso and S ‐nitroso) [11–13] and maleimides [14] reported for labeling sulfinates in proteomic analysis, including MS/MS analysis.…”