Detection of three human adenovirus species in adults with acute respiratory infection in China

Abstract

Human adenoviruses (HAdVs) are recognized as causal agents in a wide range of human diseases. However, researchers lack sufficient data on the exact HAdV species and serotypes associated with adult acute respiratory tract infections (ARTIs). To detect and characterize HAdV infections in adults in China, clinical specimens were collected from 10,310 adults with ARTIs from May 2005 to July 2010. The partial HAdV hexon gene was amplified by polymerase chain reaction (PCR), sequenced, and phylogenetically analyzed. HAdVs were detected in 86 samples (0.8%), of which 67 (77.9%) were species B (HAdV-3, -7, -11, and -14), 7 (8.1%) were species C (HAdV-1, -2, and -6), and 12 (14%) were species E (HAdV-4). HAdV-3 was the most frequently detected serotype (41/86, 47.7%), followed by HAdV-7 (13/86, 15.1%), HAdV-4 (12/86, 14.0%), and HAdV-11 (11/86, 12.8%). Patients 14-25 years old (60.5%) exhibited a higher rate of adenovirus detection than older patients. Co-infections with other respiratory viruses were observed in samples positive for HAdV species B and E. Human rhinovirus was the most commonly found virus in patients with HAdV infection. These findings provide baseline data for the surveillance and control of HAdV infection in China.

Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area, Ontario, during December 2008 to April 2010

“…These findings are consistent with other studies that have also shown that pediatric populations with acute respiratory diseases are commonly infected with HAdV-1, HAdV-2, or HAdV-3 [10]. Furthermore, the literature also demonstrates that most adult populations with HAdV infections are predominantly infected with HAdV-3, HAdV-4, HAdV-7 and HAdV-11, with a few HAdV-1, HAdV-2, HAdV-6 and HAdV-14 cases [11]. Of note in this study, HAdV-11, HAdV-17 and HAdV-21 were only found among the adult population (age ≥ 18 years).…”

Severe community-acquired pneumonia caused by adenovirus type 11 in immunocompetent adults in Beijing

“…Among them, species B (HAdV-3, -7, -11, and -14) were most common (77.9%), 24 which were similar to our adenovirous type detected in pneumonia. However, HAdV-11 was the most common in our study, especially in patients with ARDS.…”

Serotype-Specific Neutralizing Antibody Epitopes of Human Adenovirus Type 3 (HAdV-3) and HAdV-7 Reside in Multiple Hexon Hypervariable Regions

“…The subspecies B1 adenoviruses HAdV-3 and HAdV-7 have occurred epidemically and contribute greatly to pediatric acute respiratory diseases (9,11,14,26). Identification of the NAb epitopes of HAdV-3 and HAdV-7 will be beneficial for developing recombinant bivalent HAdV-3/HAdV-7 vaccines and preventing outbreak of HAdV-3 and HAdV-7 infection.…”