Detection of Trace Formaldehyde Gas Based on Quartz Crystal Microbalance Sensor in Living Environment

Hu, Jing; Zhou, Ting; Zhang, Yun Fei; Wang, Zhe; Luo, Dong; Cao, Zhong

doi:10.4028/www.scientific.net/amr.233-235.720

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…As an example, formaldehyde is a carcinogen given off by many manufactured products, including cleaning products and furniture materials such as plywood and medium-density fibreboard, with the World Health Organisation recommending an exposure limit of 0.08 ppm over a 30 min period. A number of calixarenes and calixresorcinarenes could be coated onto mass-sensitive quartz crystal microbalance (QCM) transducers and used to determine formaldehyde levels with a pyrogallol-based tetramer being capable of measuring formaldehyde levels from 109-2721 ppm in air [113]. Although this level is not sensitive enough to monitor exposure limits, this sensor does show the potential for formaldehyde binding and could also detect the higher levels associated with leaks or spills.…”

Section: Detection Of Carcinogensmentioning

confidence: 99%

Synthetic Receptors for Early Detection and Treatment of Cancer

Davis,

Higson

2023

Biosensors

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Over recent decades, synthetic macrocyclic compounds have attracted interest from the scientific community due to their ability to selectively and reversibly form complexes with a huge variety of guest moieties. These molecules have been studied within a wide range of sensing and other fields. Within this review, we will give an overview of the most common synthetic macrocyclic compounds including cyclodextrins, calixarenes, calixresorcinarenes, pillarenes and cucurbiturils. These species all display the ability to form a wide range of complexes. This makes these compounds suitable in the field of cancer detection since they can bind to either cancer cell surfaces or indeed to marker compounds for a wide variety of cancers. The formation of such complexes allows sensitive and selective detection and quantification of such guests. Many of these compounds also show potential for the detection and encapsulation of environmental carcinogens. Furthermore, many anti-cancer drugs, although effective in in vitro tests, are not suitable for use directly for cancer treatment due to low solubility, inherent instability in in vivo environments or an inability to be adsorbed by or transported to the required sites for treatment. The reversible encapsulation of these species in a macrocyclic compound can greatly improve their solubility, stability and transport to required sites where they can be released for maximum therapeutic effect. Within this review, we intend to present the use of these species both in cancer sensing and treatment. The various macrocyclic compound families will be described, along with brief descriptions of their synthesis and properties, with an outline of their use in cancer detection and usage as therapeutic agents. Their use in the sensing of environmental carcinogens as well as their potential utilisation in the clean-up of some of these species will also be discussed.

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Section: Detection Of Carcinogensmentioning

confidence: 99%