Detection of trace palladium by direct analysis in real time mass spectrometry (DART-MS)

Direct analysis in real time mass spectrometry of fused ring heterocyclic organometallic compounds

“…1,2 However, only a specic set of applications of ambient ionization mass spectrometry with organometallic compounds exist. [3][4][5] This technical note demonstrates the ability for direct analysis in real time mass spectrometry (DART-MS) 6 to readily ionize and analyze heterocyclic organometallic compounds. Heterocycles and their analogs since these molecules have been utilized in a wide variety of real world applications, including electronic materials, catalysis, medicine, eld-effect transistors (FETs), organic light-emitting diodes (OLEDS), and organic photovoltaic (OPV) cells.…”

Generic Ion Chromatography–Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances

“…Analytical methods for the determination of Pd have been extensively investigated and implemented across many scientific disciplines, with a variety of sensitive and straightforward procedures currently available. ,,− Most of the leading chemistry groups in developing efficient methodologies for Pd treatment focus the analysis on residual Pd levels. However, the development and implementation of analytical procedures targeting the scavengers has been largely ignored, with only a few isolated references on methods used for natural products and environmental applications. , In pharmaceutical chemistry, it is mandatory to demonstrate that both Pd and scavenger species are removed from the synthetic intermediates and final APIs.…”