Detection of Unprecedented CYP74 Enzyme in Mammal: Hydroperoxide Lyase CYP74C44 of the Bat Sturnira hondurensis

Gorina, Svetlana S.; Iljina, Tatiana M.; Mukhtarova, Lucia S.; Toporkova, Yana Y.; Grechkin, Alexander N.

doi:10.3390/ijms23148009

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…However, not all enzymes previously described or annotated as 9/13-HPLs possess double HPL/EAS activity. We discovered CYP74C43 (NtHPL of tobacco (Nicotiana tabacum)), which is an HPL with additional EAS activity [111], and CYP74C44 (ShHPL of the neotropical fruit bat Sturnira hondurensis) which is a true HPL [113]. Moreover, ShHPL is the only CYP74 enzyme detected in mammals.…”

Section: Epoxyalcohol Synthase Activity In Different Cyp74 Enzymesmentioning

confidence: 99%

Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

Toporkova,

Smirnova,

Gorina

2024

CIMB

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Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mammalian eicosanoids and plant octadecanoids. In plants, the main source of oxylipins is the lipoxygenase cascade, the key enzymes of which are nonclassical cytochromes P450 of the CYP74 family, namely allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and divinyl ether synthases (DESs). The most well-studied plant oxylipins are jasmonates (AOS products) and traumatin and green leaf volatiles (HPL products), whereas other oxylipins remain outside of the focus of researchers’ attention. Among them, there is a large group of epoxy hydroxy fatty acids (epoxyalcohols), whose biosynthesis has remained unclear for a long time. In 2008, the first epoxyalcohol synthase of lancelet Branchiostoma floridae, BfEAS (CYP440A1), was discovered. The present review collects data on EASs discovered after BfEAS and enzymes exhibiting EAS activity along with other catalytic activities. This review also presents the results of a study on the evolutionary processes possibly occurring within the P450 superfamily as a whole.

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Section: Epoxyalcohol Synthase Activity In Different Cyp74 Enzymesmentioning

confidence: 99%

Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

Toporkova,

Smirnova,

Gorina

2024

CIMB

Self Cite

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Cytochromes P450 evolution in the plant terrestrialization context

Werck-Reichhart,

Nelson,

Renault

2024

Phil. Trans. R. Soc. B

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Plants started to colonize land around 500 million years ago. It meant dealing with new challenges like absence of buoyancy, water and nutrients shortage, increased light radiation, reproduction on land, and interaction with new microorganisms. This obviously required the acquisition of novel functions and metabolic capacities. Cytochrome P450 (CYP) monooxygenases form the largest superfamily of enzymes and are present to catalyse critical and rate-limiting steps in most plant-specific pathways. The different families of CYP enzymes are typically associated with specific functions. CYP family emergence and evolution in the green lineage thus offer the opportunity to obtain a glimpse into the timing of the evolution of the critical functions that were required (or became dispensable) for the plant transition to land. Based on the analysis of currently available genomic data, this review provides an evolutionary history of plant CYPs in the context of plant terrestrialization and describes the associated functions in the different lineages. Without surprise it highlights the relevance of the biosynthesis of antioxidants and UV screens, biopolymers, and critical signalling pathways. It also points to important unsolved questions that would deserve to be answered to improve our understanding of plant adaptation to challenging environments and the management of agricultural traits. This article is part of the theme issue ‘The evolution of plant metabolism’.

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Detection of Unprecedented CYP74 Enzyme in Mammal: Hydroperoxide Lyase CYP74C44 of the Bat Sturnira hondurensis

Cited by 2 publications

References 41 publications

Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

Cytochromes P450 evolution in the plant terrestrialization context

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