Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy.

Algra, Paul R.; Bloem, Johan L.; Tissing, H.; Falke, T. H. M.; Arndt, J. W.; Verboom, L. J.

doi:10.1148/radiographics.11.2.2028061

Cited by 256 publications

(97 citation statements)

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“…Several preliminary studies in patients with metastatic disease from various malignancies by Steinborn et al (35) and Eustace et al (33,34) have suggested that whole-body MRI may be an accurate and cost-effective diagnostic method in the detection and screening for skeletal metastases, which may also be more sensitive and specific than bone scintigraphy (38).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Zheng

et al. 2011

Magnetic Resonance Imaging

117

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Purpose: To assess the overall diagnostic accuracy of whole-body magnetic resonance imaging (WB-MRI) in detecting bone metastases with a meta-analysis. Materials and Methods:The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB-MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow-up for at least 6 months was assessed. Meta-analysis methods were used to pool sensitivity and specificity and to construct summary receiver-operating characteristics.Results: A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB-MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845-0.939) and a pooled specificity of 0.918 (95% CI, 0.882-0.946). The subgroup without diffusion-weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922-0.984) than the subgroup with DWI (P < 0.05).Conclusion: WB-MRI was an accurate, cost-effective tool in detecting bone metastases. WB-MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High-quality prospective studies regarding WB-MRI in detecting bone metastases still need to be conducted.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Zheng

et al. 2011

Magnetic Resonance Imaging

117

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“…21,22 Planar bone scintigraphy has recently been compared with 18F PET bone studies by Schirrmeister et al in 44 patients with known prostate (20/44), lung or thyroid carcinoma. 23 The bone scans had a decreased sensitivity for detecting benign and malignant lesions in the bony pelvis compared with 18F PET bone scans.…”

Section: Discussionmentioning

confidence: 99%

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

Brown¹,

Doğan

Ell

et al. 2002

Prostate Cancer Prostatic Dis

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Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99 m Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99 m Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99 m Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99 m Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases. Keywords: 99 m Tc-bone scan; 99 m Tc-nanocolloid bone marrow scan; bone marrow aspiration; bone marrow trephine; Fluorine18 positron emission tomography bone scan; hormone-resistant prostate cancer; pelvic magnetic resonance imaging scan

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“…Short tau (time) inversion recovery imaging allows more precise depiction of tumors than spinecho sequences. [25][26][27][28] Several studies comparing scintigraphy with MRI have demonstrated that MRI is more sensitive and more specific than scintigraphy, [29][30][31][32] but to date there are few reports available assessing the potential of TB-MRI. 33 Eustace et al 34 compared TB-MRI and scintigraphy in detecting skeletal metastases in 49 patients with solid tumors.…”

Section: Discussionmentioning

confidence: 99%

Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases

Burdach

Thiel

Schöniger

et al. 2009

Bone Marrow Transplant

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We examined the role of total body magnetic resonance imaging (TB-MRI)-governed involved compartment irradiation (ICI) and high-dose chemotherapy (HDC), followed by stem cell rescue (SCR) in patients with high-risk Ewing tumors (ETs) with multiple primary bone metastases (high-risk ET-MBM). Eleven patients with high-risk ET-MBM receiving initial assessment of involved bones by TB-MRI were registered from 1995 to 2000 (group A). In all, 6 patients out of 11 had additional lung disease at initial diagnosis; all had multifocal bone disease with more than three bones involved. After systemic induction with etoposide, vincristine, adriamycin (doxorubicin), ifosfamide, and actinomycin D (EVAIA) or VAIA chemotherapy, ICI of all sites positive by TB-MRI was administered, followed by HDC and SCR. A second group matched for observation period and consisting of 26 patients with more than three involved bones at diagnosis was treated with the European Intergroup Cooperative Ewing Sarcoma Study-92 (EICESS-92) protocol (group B). These patients did not receive TB-MRI and consequently did not receive TB-MRI-governed ICI, or HDC and SCR. Survival in group A vs group B was 45 vs 8% at 5 years and 27 vs 8% at 10 years after diagnosis (log rank and Breslow: Po0.005). We conclude that TB-MRIgoverned ICI followed by HDC and SCR in ET-MBM is feasible and warrants further evaluation in prospective studies.

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Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy.

Cited by 256 publications

References 0 publications

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases

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