Detection of Vesicoureteral Reflux With Radionuclide Cystography

Jj, Conway; Lr, King; Ab, Belman; Thorson, T

doi:10.2214/ajr.115.4.720

Cited by 84 publications

(21 citation statements)

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“…With both the radionuclide techniques, DRC and IRC, the radiation dose to the child [11][12][13][14] is significantly lower than with the X-ray technique.…”

Section: Discussionmentioning

confidence: 99%

How good is technetium-99m mercaptoacetyltriglycine indirect cystography?

et al. 1994

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The aim of the present study was to estimate the sensitivity of indirect radionuclide cystography (IRC) performed with technetium-99m mercaptoacetyltriglycine (MAG3), in comparison with the micturition cystourethrography (MCUG) and direct radionuclide cystography (DRC), for the diagnosis of vesicoureteric reflux. Two groups of patients were selected: group I comprised 40 children who underwent IRC during the acute phase of urinary tract infection and an MCUG 6 weeks later; group II comprised 42 (other) children with known reflux, who underwent IRC and DRC during follow-up. Taking as the reference the total number of refluxing kidneys detected by means of any cystographic technique, 99mTc-MAG3 ICR missed two-thirds of the refluxing kidneys. Most of the small refluxes were missed, but so too were 50% of the major refluxes. Taking as the reference 99mTc dimercaptosuccinic acid (DMSA) scintigraphy, MCUG detected 91% of the patients with DM-SA abnormalities on at least one kidney, DRC detected 95%, and IRC detected 46% and 43% respectively, in groups I and II. The use of 99mTc-MAG3 IRC as the sole technique for the detection of vesicoureteric reflux gives rise to an unacceptable number of false-negative results.

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“…With both the radionuclide techniques, DRC and IRC, the radiation dose to the child [11][12][13][14] is significantly lower than with the X-ray technique.…”

Section: Discussionmentioning

confidence: 99%

How good is technetium-99m mercaptoacetyltriglycine indirect cystography?

et al. 1994

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“…Therefore, some authors prefer RNC to be more sensitive in the diagnosis of VUR [9] although precise grading is impossible. But this makes it probably an ideal methodology for the conservative follow up and after any antireflux intervention.…”

Section: Voiding Cystourethrograpy Radionuclide Cystography Sonomentioning

confidence: 99%

Radiation Safety and Future Innovative Diagnostic Modalities

Radmayr

2008

Advances in Urology

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One must demand an accurate, safe, radiation-free, and noninvasive method for reflux examination as the ideal possibility for reflux screening. Of course the available different imaging modalities are far from this ideal situation, but minimal radiation exposure is indeed a permanent objective. Additionally since all of these studies might be quite stressful to the child and the family, a specially designed and equipped environment is obligatory for the comfort of all involved. An absolute ideal modality in the diagnosis of VUR would be the definition of a certain marker in serum or urine that could identify children with VUR without the need for any interventional screening modality. Therefore more and more efforts have to be made in the future to investigate different markers for this purpose. Since reflux is one of the most frequent congenital conditions pediatric urologist have to deal with potential risks that might lead to renal insufficiency, noninvasive and radiation-free modalities should become the methods of choice, hopefully in the near future.

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“…The generally accepted reference method is radiological micturating cystography (MCU), although DRC is probably more sensitive [16,17] and has a lower radiation burden [5,18,19].…”

Section: Background and Definitionmentioning

confidence: 99%

Guidelines for direct radionuclide cystography in children

Fettich¹,

Colarinha²,

Fischer³

et al. 2003

Eur J Nucl Med Mol Imaging

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These guidelines, which summarise the views of the Paediatric Committee of the European Association of Nuclear Medicine, provide a framework which may prove helpful to nuclear medicine teams in daily practice. They contain information on the indications, acquisition, processing and interpretation of direct radioisotope cystography in children. The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations.

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Detection of Vesicoureteral Reflux With Radionuclide Cystography

Cited by 84 publications

References 0 publications

How good is technetium-99m mercaptoacetyltriglycine indirect cystography?

How good is technetium-99m mercaptoacetyltriglycine indirect cystography?

Radiation Safety and Future Innovative Diagnostic Modalities

Guidelines for direct radionuclide cystography in children

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