Detection of visual and frontoparietal network perfusion deficits in Parkinson’s disease dementia

Azamat, Sena; Arslan, Dilek Betül; Erdogdu, Emel; Kıçik, Ani; Cengiz, Sevim; Eryürek, Kardelen; Tüfekçıoğlu, Zeynep; Bılgıç, Başar; Hanağası, Haşmet; Demiralp, Tamer; Gürvıt, Hakan; Öztürk-Işık, Esin

doi:10.1016/j.ejrad.2021.109985

Cited by 11 publications

(13 citation statements)

References 46 publications

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“…Azamat et al (2021) also found that the abnormities of cerebral blood flow are very different between PDD and non-demented PD patients (i.e., PDNC and PD-MCI). They found PDD patients especially have hypoperfusion in dopaminergicallymediated fronto-parietal and non-dopaminergically-mediated visual networks (Azamat et al, 2021). Those imaging studies suggest a dual characteristics of cognitive impairment (i.e., the dopaminergic fronto-striatal pathway and the parieto-temporal pathway (Kehagia et al, 2010(Kehagia et al, , 2013.…”

Section: The Unmet Need and Future Outlookmentioning

confidence: 84%

“…They suggested that "posterior hypo-perfusion" in ASL-MRI could potentially be a biomarker for detecting cognitive dysfunction in the PD population (Arslan et al, 2020). Azamat et al (2021) also found that the abnormities of cerebral blood flow are very different between PDD and non-demented PD patients (i.e., PDNC and PD-MCI). They found PDD patients especially have hypoperfusion in dopaminergicallymediated fronto-parietal and non-dopaminergically-mediated visual networks (Azamat et al, 2021).…”

Section: The Unmet Need and Future Outlookmentioning

confidence: 99%

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Mild cognitive impairment in patients with Parkinson’s disease: An updated mini-review and future outlook

2022

Front. Aging Neurosci.

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Mild cognitive impairment (MCI) is one of the common non-motor symptoms in patients with Parkinson’s disease (PD). MCI is the transition stage between normal aging and full-blown dementia and is also a powerful predictor of dementia. Although the concept of MCI has been used to describe some of the PD symptoms for many years, there is a lack of consistent diagnostic criteria. Moreover, because of the diverse patterns of the cognitive functions, each cognitive impairment will have a different progression. In this review, we overviewed the diagnostic criteria for PD-MCI, primarily focused on the heterogeneity of PD-MCI patients’ cognitive function, including various types of cognitive functions and their progression rates. A review of this topic is expected to be beneficial for clinical diagnosis, early intervention, and treatment. In addition, we also discussed the unmet needs and future vision in this field.

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Section: The Unmet Need and Future Outlookmentioning

confidence: 84%

Section: The Unmet Need and Future Outlookmentioning

confidence: 99%

Mild cognitive impairment in patients with Parkinson’s disease: An updated mini-review and future outlook

2022

Front. Aging Neurosci.

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“…The left frontoparietal network could be considered a network involved in the control initiation and the ability to rapidly adjust control in response to feedback; it is also involved in altered emotional behavior and attentional and memory impairments [ 59 , 60 , 61 ]. The involvement of the left frontoparietal network is highlighted in the literature for MCI and is explained as documented by an alteration of memory and cognitive functions [ 62 , 63 ]. In particular, the frontoparietal network is compromised when cognitive decline begins.…”

Section: Discussionmentioning

confidence: 99%

Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?

et al. 2023

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People affected by the Long COVID-19 (LC) syndrome often show clinical manifestations that are similar to those observed in patients with mild cognitive impairments (MCI), such as olfactory dysfunction (OD), brain fog, and cognitive and attentional diseases. This study aimed to investigate the chemosensory-evoked related potentials (CSERP) in LC and MCI to understand if there is a common pathway for the similarity of symptoms associated with these disorders. Eighteen LC patients (mean age 53; s.d. = 7), 12 patients diagnosed with MCI (mean age 67; s.d. = 6), and 10 healthy control subjects (mean age 66; s.d. = 5, 7) were recruited for this exploratory study. All of them performed a chemosensory event-related potentials (CSERP) task with the administration of trigeminal stimulations (e.g., the odorants cinnamaldehyde and eucalyptus). Study results highlighted that MCI and LC showed reduced N1 amplitude, particularly in the left frontoparietal network, involved in working memory and attentional deficits, and a reduction of P3 latency in LC. This study lays the foundations for evaluating aspects of LC as a process that could trigger long-term functional alterations, and CSERPs could be considered valid biomarkers for assessing the progress of OD and an indicator of other impairments (e.g., attentional and cognitive impairments), as they occur in MCI.

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“…It was demonstrated white matter hyperintensity, number of lacunes, and microbleeds were positively correlated with the severity of motor, cognitive, and emotional impairments, while the perivascular space in the basal ganglia was only correlated with cognitive impairments. Moreover, monitoring cerebral blood flow by arterial spin labeling (ASL)‐MRI, researchers found hypoperfusion was a predictor of cognitive impairment in PD patients 16,17 . The above studies revealed multidimensional imaging markers of comorbid cognitive impairment in PD.…”

Section: Introductionmentioning

confidence: 98%

Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease

Chen,

Tang,

Wang

et al. 2024

CNS Neurosci Ther

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ObjectiveThis study aimed to investigate whether spontaneous brain activity can be used as a prospective indicator to identify cognitive impairment in patients with Parkinson's disease (PD).MethodsResting‐state functional magnetic resonance imaging (RS‐fMRI) was performed on PD patients. The cognitive level of patients was assessed by the Montreal Cognitive Assessment (MoCA) scale. The fractional amplitude of low‐frequency fluctuation (fALFF) was applied to measure the strength of spontaneous brain activity. Correlation analysis and between‐group comparisons of fMRI data were conducted using Rest 1.8. By overlaying cognitively characterized brain regions and defining regions of interest (ROIs) based on their spatial distribution for subsequent cognitive stratification studies.ResultsA total of 58 PD patients were enrolled in this study. They were divided into three groups: normal cognition (NC) group (27 patients, average MoCA was 27.96), mild cognitive impairment (MCI) group (21 patients, average MoCA was 23.52), and severe cognitive impairment (SCI) group (10 patients, average MoCA was 17.3). It is noteworthy to mention that those within the SCI group exhibited the most advanced chronological age, with an average of 74.4 years, whereas the MCI group displayed a higher prevalence of male participants at 85.7%. It was found hippocampal regions were a stable representative brain region of cognition according to the correlation analysis between the fALFF of the whole brain and cognition, and the comparison of fALFF between different cognitive groups. The parahippocampal gyrus was the only region with statistically significant differences in fALFF among the three cognitive groups, and it was also the only brain region to identify MCI from NC, with an AUC of 0.673. The paracentral lobule, postcentral gyrus was the region that identified SCI from NC, with an AUC of 0.941. The midbrain, hippocampus, and parahippocampa gyrus was the region that identified SCI from MCI, with an AUC of 0.926.ConclusionThe parahippocampal gyrus was the potential brain region for recognizing cognitive impairment in PD, specifically for identifying MCI. Thus, the fALFF of parahippocampal gyrus is expected to contribute to future study as a multimodal fingerprint for early warning.

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Detection of visual and frontoparietal network perfusion deficits in Parkinson’s disease dementia

Cited by 11 publications

References 46 publications

Mild cognitive impairment in patients with Parkinson’s disease: An updated mini-review and future outlook

Mild cognitive impairment in patients with Parkinson’s disease: An updated mini-review and future outlook

Exploratory Study on Chemosensory Event-Related Potentials in Long COVID-19 and Mild Cognitive Impairment: A Common Pathway?

Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease

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