Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs

Strzempek, Weronika; Korzeniowska, Aleksandra; Kowalczyk, Andrzej; Roth, Wiesław J.; Gil, Barbara

doi:10.3390/molecules25153501

Cited by 3 publications

(7 citation statements)

References 43 publications

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“…ZSM-55 is a synthetic zeolite with a layered structure, which has recently attracted the attention as a possible drug carrier [ 145 ]. In this study, the role of ZSM-55 as drug delivery system was tested with two different molecules: piracetam (high aqueous solubility) and ciprofloxacin (low aqueous solubility), both of them loaded into ZSM-55 by the traditional intercalation solution method.…”

Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Zeolites as Ingredients of Medicinal Products

et al. 2023

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Development of new medicinal products for particular therapeutic treatment or for better manipulations with better quality and less side effects are possible as a result of advanced inorganic and organic materials application, among which zeolites, due to their properties and versatility, have been gaining attention. This paper is an overview of the development in the use of zeolite materials and their composites and modifications as medicinal products for several purposes such as active agents, carriers, for topical treatments, oral formulations, anticancer, the composition of theragnostic systems, vaccines, parenteral dosage forms, tissue engineering, etc. The objective of this review is to explore the main properties of zeolites and associate them with their drug interaction, mainly addressing the advances and studies related to the use of zeolites for different types of treatments due to their zeolite characteristics such as molecule storage capacity, physical and chemical stability, cation exchange capacity, and possibility of functionalization. The use of computational tools to predict the drug—zeolite interaction is also explored. As conclusion was possible to realize the possibilities and versatility of zeolite applications as being able to act in several aspects of medicinal products.

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Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Zeolites as Ingredients of Medicinal Products

et al. 2023

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“…Layered zeolites exhibit adjustable interlayer porosity which can be exploited for controlled drug delivery, allowing detailed investigation of the drug release because the structure of the carrier is known [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“… Literature review on the ( A ) encapsulation and ( B ) in vitro release efficiency of synthetic/natural bioactive substances-zeolite carrier systems [ 13 , 15 , 22 , 26 , 27 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. …”

Section: Figurementioning

confidence: 99%

“…The novel study of Strzempek et al displayed the potential of a zeolite, composed of zeolite ferrierite layers with embedded choline cations, as an efficient ciprofloxacin and piracetam carrier. The established differences in the release behaviour of both drugs were attributed to strong host–guest interactions responsible for the modified, slowed down release of piracetam, while the better solubility and higher release rate of ciprofloxacin was due to protonation and subsequent weaker interactions between the drug molecules and zeolite [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…A zeolite/salicylic acid composite displayed significant antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) in a dose of 0.5 g/100 cm 3 within 1 h of contact [ 13 ]. Two independent tests on L929 mice fibroblasts showed that two-dimensional (2D) zeolite with ferrierite layer topology may be safely used as a carrier of drug molecules in moderate concentrations without negative effect on the cells’ viability or proliferation rate [ 15 ]. The application of clinoptilolite as a gastric antacid, antidiarrheic agent and a potential adjuvant in anticancer therapy has also been reported [ 1 , 21 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinoptilolite Microparticles as Carriers of Catechin-Rich Acacia catechu Extracts: Microencapsulation and In Vitro Release Study

Yaneva

Ivanova

Popov³

2021

Molecules

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The main goal of the present study was to investigate the microencapsulation, in vitro release capacity and efficiency of catechin-rich Acacia catechu extract by Clinosorbent-5 (CLS-5) microparticles by in-depth detailed analyses and mathematical modelling of the encapsulation and in vitro release kinetics behaviour of the polyphenol-mineral composite system. The bioflavanol encapsulation and release efficiency on/from the mineral matrix were assessed by sorption experiments and interpretative modelling of the experimental data. The surface and spectral characteristics of the natural bioactive substance and the inorganic microcarrier were determined by Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet/Visible (UV/Vis) spectrophotometric analyses. The maximum extent of catechin microencapsulation in acidic medium was 32%. The in vitro release kinetics study in simulated enzyme-free gastric medium (pH = 1.2) approved 88% maximum release efficiency achieved after 24 h. The in vitro release profile displayed that the developed bioflavanol/clinoptilolite microcarrier system provided sustained catechin in vitro release behaviour without an initial burst effect. Thus, the results from the present study are essential for the design and development of innovative catechin-CLS-5 microcarrier systems for application in human and veterinary medicine.

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Synthesis and Characterization of Multistage Porous Sodalite Nanocrystal Aggregate

Liu¹,

Yu²,

Wang³

et al. 2023

NANO

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Using the mixed solution of [Formula: see text]-butanol and ethanol as solvent, the sodalite nanocrystal aggregate was prepared by the solvothermal method. The influences of crystallization temperature, molar ratio Na/Al, crystallization time and silane concentration on the morphology, crystallite size, degree of crystallization and pore structure of the as-prepared samples were investigated by X-ray diffraction (XRD), BET, FTIR, Transmission Electron Microscopy (TEM) and scanning electron microscope (SEM). The results reveal that the sodalite nanocrystals are aggregated by self-assembly into the micropore–mesopore–macropore structure. Higher crystallization temperature and longer crystallization time are conducive to the growth of sodalite nanocrystals. It is a necessary condition for the formation of sodalite nanocrystals to keep high molar ratio Na/Al. The higher the molar ratio Na/Al, the more favorable the crystallization of sodalite nanocrystals. The appropriate concentration of silane agent is conducive to the preparation of smaller crystal-sized sodalite nanocrystals. After removing the silane agent by pickling, the sodalite nanocrystal aggregate is a multistage porous structure with the pore volume of 1.0133[Formula: see text]mL/g and the specific surface area of 449.73[Formula: see text]m2/g.

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Detemplated and Pillared 2-Dimensional Zeolite ZSM-55 with Ferrierite Layer Topology as a Carrier for Drugs

Cited by 3 publications

References 43 publications

Zeolites as Ingredients of Medicinal Products

Zeolites as Ingredients of Medicinal Products

Clinoptilolite Microparticles as Carriers of Catechin-Rich Acacia catechu Extracts: Microencapsulation and In Vitro Release Study

Synthesis and Characterization of Multistage Porous Sodalite Nanocrystal Aggregate

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