Detention of copper by sulfur nanoparticles inhibits the proliferation of A375 malignant melanoma and MCF-7 breast cancer cells

Líu, Hao; Zhang, Yikai; Zheng, Shanyuan; Weng, Zeping; Ma, Jun; Li, Yangqiu; Xie, Xinyuan; Zheng, Wenjie

doi:10.1016/j.bbrc.2016.07.026

Cited by 40 publications

(25 citation statements)

References 27 publications

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“…Also, TM serves as an anti-angiogenic agent and increases the efficiency of cisplatin delivery which indicates that combining both drugs will improve drug delivery and efficacy to treat different cancer diseases. A similar synergism was observed between cisplatin and the nano-S Cu chelator [104].…”

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatosupporting

confidence: 72%

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 98%

“…Cellular studies demonstrated the efficient release of curcumin into A549 cells [103]. Due to the high affinity that sulfur exhibits for Cu(I) ions and the efficiency of nanomedicine, sulfur nanoparticles have been used as Cu chelators in melanoma and breast cancer cells [104]. It has been shown that Poly ethylene glycol (PEG) Sulfur nanoparticles (nano-S) are efficient as Cu chelators and selective to Cu enriched cancer cells.…”

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

“…It has been shown that Poly ethylene glycol (PEG) Sulfur nanoparticles (nano-S) are efficient as Cu chelators and selective to Cu enriched cancer cells. Cu depletion inhibited cell growth and the MEK/ERK proliferation pathway in A375 and MCF-7 cancer cells resulting in mitotic arrest [104]. In addition to efforts to improve the specificity of Cu chelators for cancer cells, other studies have been devoted to examining their synergism with other anticancer treatments.…”

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

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Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

et al. 2018

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A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body.

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Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatosupporting

confidence: 72%

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 98%

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

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Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

et al. 2018

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“…[127][128][129] Although both could achieve the glutathione (GSH)-responsive release of D-pen, PGA-D-pen was cytotoxic to cancer cells and significantly enhanced the survival of mice, whereas gelatin-D-pen showed low anticancer efficacy, which might be caused by the difference in the cellular uptake rate. [130] Targeting copper homeostasis proteins is another way to reduce the intracellular copper levels. The chelation of copper by Nano-S resulted in a tight surficial structure, which inhibited the activation of the MEK/ERK signaling and the growth of A375 melanoma cells and MCF-7 breast cancer cells.…”

Section: Copper-depleting Nanomedicinesmentioning

confidence: 99%

Copper as the Target for Anticancer Nanomedicine

Shao

Shen

2019

Advanced Therapeutics

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Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

Yang

Song

et al. 2023

Adv Healthcare Materials

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The significantly increased copper level in tumor tissues and serum indicates the close association of copper ions with tumor development, making copper ions attractive targets in the development of novel tumor treatment methods. The advanced nanotechnology developed in the past decades provides great potential for tumor therapy, among which Cu‐based nanotherapeutic systems have received greater attention. Here, the multifaceted roles of copper ions in cancer progression are summarized and the recent advances in the copper‐based nanostructures or nanomedicines for different kinds of tumor therapies including copper depletion therapy, copper‐based cytotoxins, copper‐ion‐based chemodynamic therapy and its combination with other treatments, and copper‐ion‐induced ferroptosis and cuproptosis activation are discussed. Furthermore, the perspectives for the further development of copper‐ion‐based nanomedicines for tumor therapy and clinic translation are presented by the authors.

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Detention of copper by sulfur nanoparticles inhibits the proliferation of A375 malignant melanoma and MCF-7 breast cancer cells

Cited by 40 publications

References 27 publications

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Copper as the Target for Anticancer Nanomedicine

Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

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