Deterioration in Renal Function in Association With Co-Trimoxazole Therapy

Kalowski, Steven; Mathew, T. H.; Nanra, R. S.; Kincaid‐Smith, Priscilla

doi:10.1016/s0140-6736(73)90251-1

Cited by 115 publications

(39 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the other terminally ill patient, azotemia without other demonstrable etiology accompanied by an increase in serum creatinine from 1 to 2.7 occurred during STP therapy. Colistimethate potential for nephrotoxicity is well described (11), and trimethoprim-sulfamethoxazole nephrotoxicity, though apparently less frequent, may also be a hazard (9). Accordingly, the combination STP should be used cautiously, with routine every-other-day determinations of blood urea nitrogen and serum creatinine.…”

Section: Methodsmentioning

confidence: 99%

Sulfamethoxazole-Trimethoprim-Polymyxin Therapy of Serious Multiply Drug-Resistant Serratia Infections

Thomas

Leonard

Alford

1976

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Nonpigmented multiply drug-resistant Serratia marcescens caused an extensive outbreak of infection at the Nashville Veterans Administration Hospital. Isolates were of one serotype resistant to all currently available antimicrobial agents for therapy of systemic infections except for occasional susceptibility to chloramphenicol and kanamycin. Frequently strains were susceptible to nalidixic acid, and all were susceptible to amikacin (BB-K8). Drug-resistant strains caused 130 infections, 12 bacteremias, and 7 infection-associated deaths. Combinations of antimicrobial agents were evaluated for synergism against Serratia strains from infected patients. “Checkerboard” isobolograms indicated in vitro static synergism between sulfamethoxazole, trimethoprim, and polymyxin (STP). Killing curves using clinically achievable concentrations of STP verified the bactericidal effect of STP against these strains. In a daily dosage of 1,600 mg of sulfamethoxazole and 320 mg of trimethoprim orally in combination with 100 to 300 mg of colistimethate parenterally, serum cidal levels at 1:8 or greater were achieved in five of six patients. Clinical improvement or microbiological cure was effected in four of six patients. STP may be potentially useful for selected Serratia infections for which single agents are unavailable or ineffective.

show abstract

Section: Methodsmentioning

confidence: 99%

Sulfamethoxazole-Trimethoprim-Polymyxin Therapy of Serious Multiply Drug-Resistant Serratia Infections

Thomas

Leonard

Alford

1976

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…A deterioration in parameters of renal function during co-trimoxazole (sulphamethoxazole + trimethoprim) therapy has been reported (Kalowski et al, 1973;Berglund, Killander & Pompeius, 1975;Shouval, Ligumsky & Ben-Ishay, 1978;Braiutigam et al, 1979;Trollfors, Wahl & Alestig, 1980). However, others have concluded that these parameters are not influenced by co-trimoxazole (Tasker, MacGregor & De Wardener, 1975;Rosenfeld, Najenson & Grosswater, 1975;Denneberg et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

The effect of co‐trimoxazole on serum creatinine.

Dijkmans¹,

Hooff²,

Wolff³

et al. 1981

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…This drug is excreted from the kidney and is known to have side effects such as acute tubular necrosis and interstitial nephritis (1)(2)(3). Tmp-Smxhas been reported to cause renal salt wasting and metabolic acidosis (4), but appears to have no remarkableeffects on serum electrolyte levels as long as regular-dose Tmp-Smx is administered (5).…”

Section: Introductionmentioning

confidence: 99%

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

et al. 1995

View full text Add to dashboard Cite

An antimicrobial agent trimethoprim-sulfamethoxazole (Tmp-Smx)does not usually cause electrolyte disturbances at regular doses, and few cases ofTmp-Smx-inducedelectrolyte imbalance have been reported in the English-language literature to date. Recently, however, we treated two patients with Pneumocystis carinii pneumoniawhodeveloped severe hyponatremia and hyperkalemia on administration of high-dose Tmp-Smx.These electrolyte disturbances were attributable to the direct effect of Tmp-Smxon the renal distal tubules, were reversible, and corrected by infusion of a sodium-enriched and potassium-free liquid. Therefore, it is suggested that even after electrolyte disturbances have occurred, high-dose Tmp-Smxtherapy may be continued for severe infectious diseases under appropriate electrolyte correction. (Internal Medicine 34: 96-99, 1995)

show abstract

Deterioration in Renal Function in Association With Co-Trimoxazole Therapy

Cited by 115 publications

References 7 publications

Sulfamethoxazole-Trimethoprim-Polymyxin Therapy of Serious Multiply Drug-Resistant Serratia Infections

Sulfamethoxazole-Trimethoprim-Polymyxin Therapy of Serious Multiply Drug-Resistant Serratia Infections

The effect of co‐trimoxazole on serum creatinine.

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

Contact Info

Product

Resources

About