Determinação de metil-etil-cetona em amostras de urina com amostragem por micro extração em fase sólida (MEFS) em headspace associada à cromatografia gasosa com detector de ionização de chama (CG-DIC)

Antunes, Marina Venzon; Linden, Rafael

doi:10.1590/s0100-40422008000800043

Quím. Nova

2008

DOI: 10.1590/s0100-40422008000800043

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Determinação de metil-etil-cetona em amostras de urina com amostragem por micro extração em fase sólida (MEFS) em headspace associada à cromatografia gasosa com detector de ionização de chama (CG-DIC)

Marina Venzon Antunes¹,

Rafael Linden²

Abstract: Determinação De metil-etil-cetona em amostras De urina com amostragem por micro extração em fase sóliDa (mefs) em headspace associaDa à cromatografia gasosa com Detector De ionização De chama (cg-Dic) marina Venzon antunes e rafael linden* Instituto de Ciências da Saúde, Centro Universitário Feevale, Rodovia RS 239, n. 2755, 93352-000 Novo Hamburgo -RS, Brasil Recebido em1/2/08; aceito em 20/6/08; publicado na web em 24/10/08 DETERMINATION OF METHYL ETHYL KETONE IN URINE SAMPLES BY HEADSPACE SOLID PHASE MICRO … Show more

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Cited by 4 publications

References 6 publications

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Microextraction techniques for occupational biological monitoring: Basic principles, current applications and future perspectives

Sohrabi,

Rahimian,

Yousefinejad

et al. 2024

Biomedical Chromatography

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The application of green microextraction techniques (METs) is constantly being developed in different areas including pharmaceutical, forensic, food and environmental analysis. However, they are less used in biological monitoring of workers in occupational settings. Developing valid extraction methods and analytical techniques for the determination of occupational indicators plays a critical role in the management of workers’ exposure to chemicals in workplaces. Microextraction techniques have become increasingly important because they are inexpensive, robust and environmentally friendly. This study aimed to provide a comprehensive review and interpret the applications of METs and novel sorbents and liquids in biological monitoring. Future perspectives and occupational indicators that METs have not yet been developed for are also discussed.

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Microextraction techniques for occupational biological monitoring: Basic principles, current applications and future perspectives

Sohrabi,

Rahimian,

Yousefinejad

et al. 2024

Biomedical Chromatography

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Metabolism of inhaled methylethylketone in rats

Cosnier

Grossmann

Nunge

et al. 2017

Drug and Chemical Toxicology

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Methylethylketone (MEK) is widely used in industry, often in combination with other compounds. Although nontoxic, it can make other chemicals harmful. This study investigates the fate of MEK in rat blood, brain and urine as well as its hepatic metabolism following inhalation over 1 month (at 20, 200 or 1400 ppm). MEK did not significantly accumulate in the organism: blood concentrations were similar after six-hour or 1-month inhalation periods, and brain concentrations only increased slightly after 1 month's exposure. Urinary excretion, based on the major metabolites, 2,3-butanediols (± and meso forms), accounted for less than 2.4% of the amount inhaled. 2-Butanol, 3-hydroxy-2-butanone and MEK itself were only detectable in urine in the highest concentration conditions investigated, when metabolic saturation occurred. Although MEK exposure did not alter the total cytochrome P450 concentration, it induced activation of both CYP1A2 and CYP2E1 enzymes. In addition, the liver glutathione concentration (reduced and oxidized forms) decreased, as did glutathione S-transferase (GST) activity (at exposure levels over 200 ppm). These metabolic data could be useful for pharmacokinetic model development and/or verification and suggest the ability of MEK to influence the metabolism (and potentiate the toxicity) of other substances.

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The Application of In Situ Methods to Monitor VOC Concentrations in Urban Areas—A Bibliometric Analysis and Measuring Solution Review

Wiśniewska

Szyłak-Szydłowski

2022

Sustainability

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Urbanisation development affects urban vegetation both directly and indirectly. Since this process usually involves a dramatic change in land use, it is seen as likely to cause ecological pressure on local ecosystems. All forms of human activity, including urbanisation of areas close to residential buildings, significantly impact air quality. This study aims to identify and characterise different measurement solutions of VOCs, allowing the quantification of total and selective compounds in a direct at source (in situ) manner. Portable devices for direct testing can generally be divided into detectors, chromatographs, and electronic noses. They differ in parameters such as operating principle, sensitivity, measurement range, response time, and selectivity. Direct research allows us to obtain measurement results in a short time, which is essential from the point of view of immediate reaction in the case of high concentrations of tested compounds and the possibility of ensuring the well-being of people. The paper also attempts to compare solutions and devices available on the market and assess their application.

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Determinação de metil-etil-cetona em amostras de urina com amostragem por micro extração em fase sólida (MEFS) em headspace associada à cromatografia gasosa com detector de ionização de chama (CG-DIC)

Cited by 4 publications

References 6 publications

Microextraction techniques for occupational biological monitoring: Basic principles, current applications and future perspectives

Microextraction techniques for occupational biological monitoring: Basic principles, current applications and future perspectives

Metabolism of inhaled methylethylketone in rats

The Application of In Situ Methods to Monitor VOC Concentrations in Urban Areas—A Bibliometric Analysis and Measuring Solution Review

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