Determinação espectrofotométrica de cefalexina em formulações farmacêuticas explorando a sua reação de transferência de carga com a quinalizarina

Paula, Carlos Eduardo R. de; Almeida, Vanessa G. K.; Cassella, Ricardo J.

doi:10.1590/s0100-40422010000400029

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…The absorbances of the solutions were measured and the results are displayed in Figure 6. The condition that provided the higher analytical signal was shown to be two quinalizarin for each rosuvastatin, corroborating other studies in the literature for other charge transfer reactions with quinalizarin (Paula, Almeida, Cassella, 2010;Gouda, El-Sheikh, El-Azzazy, 2012).…”

Section: Study Of the Reaction Stoichiometrysupporting

confidence: 88%

Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Lima

Cassella

Pacheco

2017

Braz. J. Pharm. Sci.

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This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L -1 . The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L -1 ), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).

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Section: Study Of the Reaction Stoichiometrysupporting

confidence: 88%

Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Lima

Cassella

Pacheco

2017

Braz. J. Pharm. Sci.

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“…It is commonly employed in contemporary analysis as a separation method to determine the presence or absence of antibiotics over a predetermined concentration level [ 38 , 39 ]. It can also be used to evaluate and categorize pure and impure antibiotic preparations as well as assay antibiotics quantitatively in bulk or pharmaceutical preparations [ 40 , 41 ].…”

Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

“…Coulomb attraction holds oppositely charged ions together in solution in the ion-pair complex [ 56 ]. Some antibiotics have been analyzed using spectrophotometric methods including amoxicillin [ 40 ], azithromycin [ 41 , 57 ], tetracycline, doxycycline [ 58 ], and cefixime trihydrate [ 59 ]. They have also been used to analyze gentamicin sulfate [ 60 ], cefadroxil, ceftazidime, cefazolin sodium, cefoperazone sodium, cefaclor, cephaprin sodium, cefotaxime sodium, and cefuroxime sodium [ 61 ].…”

Section: Methods Used To Analyze Antibioticsmentioning

confidence: 99%

A Review of Methods for Removal of Ceftriaxone from Wastewater

Karungamye

Rugaika

Mtei

et al. 2022

JoX

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The presence of pharmaceuticals in surface water and wastewater poses a threat to public health and has significant effects on the ecosystem. Since most wastewater treatment plants are ineffective at removing molecules efficiently, some pharmaceuticals enter aquatic ecosystems, thus creating issues such as antibiotic resistance and toxicity. This review summarizes the methods used for the removal of ceftriaxone antibiotics from aquatic environments. Ceftriaxone is one of the most commonly prescribed antibiotics in many countries, including Tanzania. Ceftriaxone has been reported to be less or not degraded in traditional wastewater treatment of domestic sewage. This has piqued the interest of researchers in the monitoring and removal of ceftriaxone from wastewater. Its removal from aqueous systems has been studied using a variety of methods which include physical, biological, and chemical processes. As a result, information about ceftriaxone has been gathered from many sources with the searched themes being ceftriaxone in wastewater, ceftriaxone analysis, and ceftriaxone removal or degradation. The methods studied have been highlighted and the opportunities for future research have been described.

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“…Os antibióticos são de origem natural, semi-sintéticos ou sintéticos. Os de origem natural e semi-sintéticos (Paula, 2019). São caracterizados em β-lactâmicos (cefalosporinas, penicilinas, carbapeninas, oxapeninas e monobactamas), aminoglicosídeos, tetraciclinas, macrolídeos, peptídeos cíclicos (glicopeptídeos, lidodepsipeptídeos), estreptograminas, lincosamidas, cloranfenicol, rifamicina, entre outros (Guimarães, Momesso e Pupo, 2010).…”

Section: Estrutura E Mecanismo De Ação Dos Antibióticosunclassified

Uso Irracional De Antibióticos E a Resistência Bacteriana No Tratamento De Doenças Infecciosas Negligencias: Uma Revisão De Literatura

Rocha,

Dutra,

Dutra

et al. 2024

Braz. J. Implantol. Health Sci.

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Os antibióticos são fármacos sintetizados ou de forma natrais, que diminui as doenças infecciosas negligenciadas, com a morte dos micro-organismos presentes. O consumo indiscriminado e desnecessário, eleva ao aumento de resistência bacteriana e consequencias a saúde. No presente momento, a resistência bacteriana tornou-se um desafio mundial de saúde, encarregados por diferentes impactos na comunidade e na saúde pública e privada. Prescrições errôneas, informações erradas, conhecimento empirico, ilegibilidade nos receitúarios médicos e odontólogicos cooperam para o uso irracional de antbióticos. Objetivos: O presente estudo, visa expressar sobre o uso irracional de antibióticos, e a resistência bacteriana no tratamento de doenças infecciosas negligenciadas. Metodologia: Trata-se de um estudo de revisão bibliógrafica de literatura, realizadas pelo Google acadêmico, LILACS e SciELO. Os dados foram tabulados pelo Software Excell e a plataforma Mendeley, diminuindo a duplicidade. Resltados: Conclui-se o uso irracional de antibióticos leva a morbidade e mortalidade, e a resistência bacteriana, além de causar um problema mundial de saúde pública multidisciplinar, aumenta os nivéis de morbimortalidade, e a resistência bacteriana. Conclusão: A falta de informação, profissionais de saúde qualificados, má qualidade nos serviços de saúde, a falta de recursos financeiros e do profissional farmacuêtico na equipe multidisciplinar diminui o uso correto de antibióticos e o combate ao uso irracional e inapropriado.

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Determinação espectrofotométrica de cefalexina em formulações farmacêuticas explorando a sua reação de transferência de carga com a quinalizarina

Cited by 8 publications

References 12 publications

Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

A Review of Methods for Removal of Ceftriaxone from Wastewater

Uso Irracional De Antibióticos E a Resistência Bacteriana No Tratamento De Doenças Infecciosas Negligencias: Uma Revisão De Literatura

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