Determinación de resistencia antihelmíntica frente a ivermectina de nematodos del bovino en dos predios del sur de Chile

Sievers, G; Alocilla, A

doi:10.4067/s0301-732x2007000100010

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…It binds glutamate ‐ gated chloride channel of parasite leading to increased permeability and hyperpolarisation of its nerve and muscle cells. Moreover, it interacts with other chloride channels (Sievers & Alocilla, ). Ivermectin was characterised by its high lipid solubility, so it is widely distributed within the whole body and is mainly metabolised by oxidative pathways via the liver and excreted mainly in the faeces.…”

Section: Introductionmentioning

confidence: 99%

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

El-Maddawy

Naby

2017

Andrologia

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This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin-like growth factor binding protein-3 (IGFBP-3) and heat-shock protein A1 (HSPA1)) genes in the testes, as well as on male rat fertility parameters. Results revealed that expression levels of IGFBP-3 and HSPA1 were significantly increased in testis of the IVM-treated group relative to the control group. Furthermore, injection of ivermectin showed a significant decrease in serum testosterone level, sperm count, motility %, live sperm% and index weight of reproductive organs, and a significant increase in sperm abnormalities. Moreover, IVM induced oxidative stress and pathological alterations in the testes. Meanwhile, the administration of ALA with IVM prevented testicular damage and improved all previous parameters. We concluded that ivermectin has undesirable effects on male fertility and altered expression of IGFBP-3 and HSPA1 genes in the testes, while the administration of alpha lipoic acid can ameliorate the adverse effects of ivermectin.

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Section: Introductionmentioning

confidence: 99%

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

El-Maddawy

Naby

2017

Andrologia

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“…Most of the times, IVM has been adopted as the only tool for anthelmintic control, without considering other epidemiologic variables (Sievers & Alocilla 2007, Canul-Ku et al 2011. In Argentina, the ϐirst references to anthelmintic resistance to IVM in cattle were made by Fiel et al (2000Fiel et al ( , 2001 and Anziani et al (2001), and afterwards, cases of anthelmintic resistance to different chemical groups of drugs have been frequently described (Mejia et al 2003, Anziani et al 2004, Caracostantogolo et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

et al. 2012

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The aim was to evaluate for 75 days the impact on production of the remaining burden of ivermectin (IVM)-resistant parasites in naturally infected feedlot calves. The herds came from tick-infested areas of cattle breeding where the systematic use of IVM to control tick increases the gastrointestinal parasites resistant to this drug. This investigation was carried out in two commercial feedlots in Buenos Aires province. In feedlot A, two groups of 35 animal each received IVM 1% and the other received ricobendazole (RBZ) 10% respectively. The same was done in feedlot B. On day 0, two groups of 35 animals were made in feedlots A and B. Fecal samples were taken on days 0, 22, 54 and 75 pos-treatment (PT), and body weight was registered, from each animal. Fecal samples were processed for individual count of eggs per gram (EPG) and pooled fecal culture was carried out for identiϐication of the parasite genus in each sampling. Fecal egg count reduction test (FECR) was calculated on day 22 PT. The study design used was a totally randomized block, with commercial feedlot and sex as block variables. For data analysis, a mixed model of the SAS statistical program was used. The FECR average on day 22 was 28.4% in the IVM group, and 94,2 % in the RBZ group . From this date on, signiϐicant differences in EPG were kept until day 54. EPG counts were only equal near the end of the trial, on day 75 (p=0.16). In both commercial feedlots, especially in the IVM group, Cooperia spp. was the most prevalent parasite in the fecal cultures. Signiϐicant differences in weight (P<0.01) on post-treatment day 75 was found between the average weight in the RBZ and the IVM group (246 vs. 238 kg respectively), what means a difference of 8.3% in gains. The importance for production in the antiparasite failure treatment in commercial feedlots was demonstrated, and the need of pos-treatment controls to evaluate the efϐicacy of the antiparasitic administered is emphasized.

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“…Most of the studies included in this SR and MA reported using a dosage of 0.2mg/Kg (ALONSO-DIAZ et al 2015;ARANTES et al, 1995;CANUL-KU et al, 2012;CONDI et al, 2009;LLORENS et al, 2014;MENA et al, 2008;RANGEL et al, 2005;RANJAN et al, 1992;SIEVERS & FUENTEALBA, 2003;SIEVERS & ALOCILLA, 2007;STAFFORD & COLES, 1999). Correct dosing in the application of anthelmintic drugs may prevent the development of AHR (LESPINE et al, 2012), but farmers sometimes treat animals at dose rate below those recommended by the manufacturer.…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

Baiak

Lehnen

Rocha

2019

Rev. Bras. Parasitol. Vet.

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The purpose of this work was to identify, critically assess, and summarize available data from primary research about the anthelmintic resistance of injectable macrocyclic lactones in cattle. Meta-analysis was performed to estimate the pooled Odds Ratio and 95% Confidence Intervals. Of the 1504 abstracts screened for eligibility, 80 were deemed relevant for full publication review. Thirteen publications were included in the qualitative synthesis and assessed for systematic bias. Only five studies were included in the quantitative analysis because they showed a low risk of producing biased results in all the parameters. The forest plot indicated four studies that discuss anthelmintic resistance (P<0.05), while only one study did not discuss anthelmintic resistance (P<0.05). The pooled estimate showed 0.59 (95% Confidence intervals: 0.08, 0.47) times higher odds for studies that report anthelmintic resistance than for studies reporting efficacious anthelmintic treatment, with significant and substantially low heterogeneity (I2=25%). Anthelmintic resistance to injectable macrocyclic lactones is a reality. There are need to improve methodological reporting in studies, which is a problem for investigations that involves systematic review and meta-analysis (SR-MA).

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Determinación de resistencia antihelmíntica frente a ivermectina de nematodos del bovino en dos predios del sur de Chile

Cited by 8 publications

References 15 publications

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

Effects of ivermectin and its combination with alpha lipoic acid on expression of IGFBP-3 and HSPA1 genes and male rat fertility

Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina

Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

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