Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review

Adherence to Capecitabine Treatment and Contributing Factors among Cancer Patients in Malaysia

“…This finding is contrary with previous studies whereby underlying diseases were often found to be inversely correlated with adherence in previous studies (Ahmad et al, 2013;Verbrugghe et al, 2013). Comorbid patients are usually related to multiple drug use, elevated anxiety and depression due to the presence of underlying disease that may be the reasons of being non-adherent.…”

“…Larger group of patients with other types of cancer should be involved in the future to give more reliable information about this association. Cancer stage as well did not show any association with adherence score and this is supported by several previous studies (Partridge et al, 2010;Thivat et al, 2013;Verbrugghe et al, 2013).…”

“…It was a commonly held view that younger age is more associated with adherence (Hassan et al, 2006;Verbrugghe et al, 2013).This study also showed the same negative correlation between age and adherence score but not significantly proven.…”

“…The number of concomitant drugs taken has shown to be strongly correlated with adherence in previous study (Ramli et al, 2012;Verbrugghe et al, 2013). However, it was not stated which type of drugs have been considered as the concomitant drugs whether it also included injectable drugs or short terms drugs such as antibiotics.…”

“…Occurrence of medication inconvenience and side effects have been widely studied as the contributing factors to adherence and the result was frequently found to be significant regardless of any type of chronic diseases (Hassan et al, 2006;Spoelstra and Given, 2011;AlGhurair et al, 2012;A hmad et al, 2013;Verbrugghe et al, 2013).…”