Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study

Onat, Altan; Uyarel, Hüseyin; Hergenc, Gtilay; Karabulut, Ahmet; Albayrak, Sinan; Can, Günay

doi:10.1016/j.atherosclerosis.2006.03.012

Cited by 117 publications

(80 citation statements)

References 26 publications

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“…On the other hand, more women had three or four risk factors in comparison with men, which means that the female participants had a higher prevalence of MetS (presence of 3 or more risk factors) according to the findings of this study. A higher prevalence of MetS among women compared with men is supported by some other researches (21,31). Furthermore, in some other studies such as one by Santos et.al, almost the same prevalence in both genders was reported (32).…”

Section: Discussionmentioning

confidence: 52%

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

Eftekhari¹,

Sohrabi²,

Parsa³

et al. 2015

Int Cardiovasc Res J

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obesity secondary to medication and genetic or endocrine disorders were excluded from the study. Weight and height were measured for calculating Body Mass Index (BMI). Waist circumference and blood pressure were measured, as well. Plasma glucose, serum High Density Lipoprotein-cholesterol (HDL-c), and Triglyceride (TG) were also analyzed. The presence of MetS was determined using Adult Treatment Panel-III (ATP-III) criteria. Results:The results showed significant correlations between age and waist circumference, Fasting Blood Sugar (FBS), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP). Moreover, statistically significant relationships were found between waist circumference and TG, SBP, DBP, and BMI. Significant correlations were also observed between FBS and TG, SBP, and DBP. Besides, there were strong correlations between TG and HDL-c, SBP, DBP, and BMI. Moreover, BMI, SBP, and DBP were significantly correlated. In addition, serum HDL-c was negatively associated with most of the variables. The prevalence of pre-diabetes, pre-hypertension, and hypertriglyceridemia was higher among males. On the other hand, the prevalence of hypertension, diabetes, high waist circumference, and MetS was significantly higher among the female participants. Conclusions: A better understanding of the role of gender in the prevalence of MetS is important in developing prevention and treatment strategies.

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Section: Discussionmentioning

confidence: 52%

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

Eftekhari¹,

Sohrabi²,

Parsa³

et al. 2015

Int Cardiovasc Res J

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“…Studies of a representative sample of Turkish adults showed the incidence of metabolic syndrome to be 23.0% in males and 24.9% in females over a 5.9-year follow-up period (Onat et al 2007a(Onat et al , 2007b). Zabetian and colleagues showed a 20.4% age-adjusted incidence of metabolic syndrome (male: 18.4%, female: 23.1%) over a 3-year follow-up period (Zabetian et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Association between Short Sleep Duration and High Incidence of Metabolic Syndrome in Midlife Women

Choi

Kim

et al. 2011

Tohoku J. Exp. Med.

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Chronic sleep deprivation is increasingly common in industrialized societies. Short sleep duration has been associated with a number of negative health outcomes. The objectives of this study were to investigate the association between self-reported sleep duration and the presence of metabolic syndrome (combination of central obesity, triglyceride, high density lipoprotein, blood pressure, fasting plasma glucose) in adults during midlife. The Korean Genomic Rural Cohort (KGRC) is a cohort study of aged 40 to 70 years in rural Korea. This study focuses on the prevalence, incidence, and risk factors for chronic degenerative disorders, such as hypertension, diabetes, osteoporosis, respiratory diseases, and metabolic syndrome. The baseline sample of participants in the KGRC study was recruited in 2005-2006 (phase 1). Respondents were followed until 2008-2009 (phase 2). The final sample included 1,107 subjects: 386 males (34.9%) and 721 females (65.1%). The incidence rate of metabolic syndrome in our sample was 18.4% (21.2% for males and 16.9% for females). Subjects sleeping < 6 hours a day (HR: 1.798; 95% CI: 1.06-3.05) were significantly more likely to experience metabolic syndrome than participants sleeping 6 to 7.9 hours a day after controlling for potential covariates (age, body mass index, menopause, smoking, alcohol and physical activity). Shorter sleep duration was associated with the high incidence of metabolic syndrome among females only. In conclusion, shorter sleep duration may be a significant risk factor for the development of metabolic syndrome in women.

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“…Type-2 diabetes was diagnosed with the criteria of the American Diabetes Association [11] , namely by self report or when plasma fasting glucose was ≥ 7 mmol/L or when 2-h postprandial glucose was Table 1 Characteristics of sample (n = 1224) by gender and serum adiponectin (in μg/mL) tertiles > 11 mmol/L. MetS was identified when 3 out of the 5 criteria of the National Cholesterol Education Program ATP-Ⅲ were met, modified for prediabetes (fasting glucose 5.56-6.95 mmol/L) [12] and further for male abdominal obesity using as cut-point ≥ 95 cm, as assessed in the TARF study [13] . Information on the mode of death was obtained from first-degree relatives and/or health personnel of the local health office.…”

Section: Definitionsmentioning

confidence: 99%

High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Onat¹,

Aydın²,

Can³

et al. 2013

WJD

Self Cite

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AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome. METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements (n = 1224) were analyzed prospectively at a mean of 3.8 years' follow-up, using continuous values or sex-specific tertiles. Total adiponectin was assayed by an ELISA kit. Type-2 diabetes was identified by criteria of the American Diabetes Association. Hypertension was defined as a blood pressure ≥ 140 mmHg and/or ≥ 90 mmHg and/or use of antihypertensive medication. Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders. RESULTS:In models of multiple linear regression, sex hormone-binding globulin, fasting insulin (inverse) and, in men, age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine. Cox regression analyses for incident coronary heart disease (CHD), adjusted for sex, age, non-HDL cholesterol, waist circumference and C-reactive protein, revealed significant inverse association with adiponectin tertiles in men but not women (HR = 0.66; 95%CI: 0.32-1.38 for highest tertile). Cox regression for type-2 diabetes in a similar model (wherein glucose replaced non-HDL cholesterol), adiponectin tertiles appeared to protect in each gender. HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles (P -trend = 0.67). CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and, in women, against CHD, presumably paralleling impairment in renal function as well. Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying.

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Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in Turkish men: A prospective cohort study

Cited by 117 publications

References 26 publications

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

Association between Short Sleep Duration and High Incidence of Metabolic Syndrome in Midlife Women

High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

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