Determinants of adiponectin levels throughout pregnancy in women with type 1 diabetes mellitus

Gutaj, Paweł; Sibiak, Rafał; Wirlstlein, Przemysław; Wender-Ożegowska, Ewa

doi:10.20452/pamw.15227

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…This inverse correlation with the gestational age of the fetus is not observed in overweight women. This dependency can be explained with the need for maternal pregnancy-related fat deposition and the downregulation of adiponectin expression in response to increasing adipose mass [64][65][66][67]. Hence, despite that singular studies based on a small size sample group question the correlation of adiponectin level with gestation advancement, the general consensus states that concentration of this protein decreases significantly between the first and third trimester of pregnancy.…”

Section: Adiponectinmentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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Section: Adiponectinmentioning

confidence: 99%