Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects

Akanji, Abayomi O.; Al-Isa, Abdulwahab Naser; Thalib, Lukman

doi:10.1515/cclm.2011.645

Cited by 10 publications

(13 citation statements)

References 41 publications

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“…Even after adjusting for adiposity and age, the correlation of E-selectin to HOMA-IR persisted. Other investigators had similar findings that showed that adhesion molecule concentrations were influenced by sex, age and HOMA-IR in individuals with low cardiometabolic risk (21,22). Apart from the limitations of the present study's design, our findings could suggest that visceral adipose tissue might be influencing E-selectin synthesis, maybe through adipose tissue derived cytokines that induce insulin resistance.…”

Section: Discussionsupporting

confidence: 62%

“…We found that the greater concentrations of a soluble molecule that promotes leukocyte adhesion to endothelia in men is compatible with higher cardiovascular risk in this sex, particularly in the 35 to 54 age group. The association with sex was previously described in a sample of young individuals (21,22). Since the production of adhesion molecules is stimulated by metabolic disturbances (33), it was important to test the association of E-selectin with an insulin resistance index.…”

Section: Discussionmentioning

confidence: 99%

“…Also, studies have investigated the role of other inflammatory and endothelial dysfunction markers in predicting diabetes and CVDs. However, limited data are reported concerning the distribution of these circulating biomarkers in individuals with lower cardiometabolic risk and how those values vary according to age and sex (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease

Almeida-Pititto

Ribeiro-Filho

Barreto

et al. 2016

Arch. Endocrinol. Metab.

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Objective: Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods: This crosssectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results: Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions: In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk. Arch Endocrinol Metab. 2016;60(6):573-81

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease

Almeida-Pititto

Ribeiro-Filho

Barreto

et al. 2016

Arch. Endocrinol. Metab.

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“…In the current study, total cholesterol, triglycerides, LDL-c, fasting blood glucose, fasting insulin, and HOMA-IR were significantly increased in obese children in comparison with controls (p value 0.000, 0.000, 0.03, 0.01, 0.00, and 0.00 respectively). These findings were consistent with the findings of others [22,[29][30][31].…”

Section: Discussionsupporting

confidence: 94%

“…Also, Akanji et al [31] found that PAI-1 is associated with insulin resistance found in obese subjects, and Al-Daghri et al [30] found that PAI-1 levels were correlated with HOMA-IR and fasting serum insulin. Many earlier reports had suggested associations between PAI-1 with insulin sensitivity, WC, and BMI in obese children and adolescents [33,34]; this is in agreement with the current results as PAI-1 was found to be correlated with BMI, HOMA-IR, and insulin in obese children.…”

Section: Discussionmentioning

confidence: 99%

Assessment of plasminogen activator inhibitor-1 in obese Egyptian children

Mira

Anwar

El-Din

et al. 2020

Egypt Pediatric Association Gaz

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Background: Plasminogen activator inhibitor-1 (PAI-1) is mainly produced in the liver and in the adipose tissue. Normal fibrin clearance mechanisms were found to be affected by high plasma PAI-1 levels and thus increases risk of thrombosis. The aim of the current study was to expound the childhood obesity effect on circulating PAI-1 and interpret the relation of PAI-1 to metabolic syndrome. This cross-sectional study was conducted on 43 obese children following in the Children Hospital and compared to 44 healthy sex-and age-matched controls. All recruited cohort are subjected to anthropometric measurements: weight, height, BMI, waist circumference, hip circumference, and skin fold thickness (biceps, triceps, and subscapular), and laboratory investigations in the form of lipid profile, fasting blood sugar, fasting insulin, insulin resistance estimated by HOMA-IR, and plasminogen activator inhibitor-1. Results: The level of plasminogen activator inhibitor-1 in the obese group was significantly higher than that in the control group (47.98 ± 17.42 vs. 28.00 ± 11.35 respectively). PAI-1 showed positive significant correlation to anthropometric measurements: BMI (p = 0.000), weight (p = 0.000), biceps skin fold thickness (p = 0.04), triceps skin fold thickness (p = 0.4), and subscapular skin fold thickness (p = 0.04). Also, a significant positive correlation was found between PAI-1 and systolic (p = 0.000) and diastolic blood pressure (p = 0.04). Positive correlations were found between PAI-1 and cholesterol (p = 0.000), triglycerides (p = 0.02), LDL-c (p = 0.000), insulin (p = 0.000), and HOMA-IR (r = 0.5, p = 0.02). Conclusion: Fat mass accumulation is related to high PAI-1 levels, which might in turn contribute to cardiovascular risk. Plasminogen Activator Inhibitor-1 is a good predictive test for metabolic syndrome in obese children.

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Lipoprotein(a) throughout life in women

Corral,

Matta,

Aguilar-Salinas

et al. 2024

American Journal of Preventive Cardiology

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Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects

Abstract: The blood levels of the prothrombotic biomarkers ;ibLp(a), PAI-1, and FBG;ic in healthy Kuwaiti adolescent subjects are variably influenced by age, gender, body mass and socio-demographic factors.

Cited by 10 publications

References 41 publications

Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease

Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease

Assessment of plasminogen activator inhibitor-1 in obese Egyptian children

Lipoprotein(a) throughout life in women

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