Determinants of bone density in normal women: risk factors for future osteoporosis?

Stevenson, John C.; Lees, Belinda; Devenport, M; Cust, MP; Ganger, K. F.

doi:10.1136/bmj.298.6678.924

Cited by 387 publications

(99 citation statements)

References 24 publications

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“…143 Despite limitations in this study (women who drank more alcohol also tended to be taking hormone replacement therapy, and the method for measuring bone mineral density was not described), other studies have also observed increased bone density in women who drink. [144][145][146] The findings of decreased vertebral deformity and increased bone density in postmenopausal women who drink contrasts with small studies suggesting that premenopausal alcohol-dependent women may be more likely to develop osteoporosis. 125,147 A study of 19 noncirrhotic alcohol-dependent women with normal menstrual cycles who drank more than 15.5 drinks a day on average, found that serum markers of bone formation were significantly lower in these women than in age-and weight-matched control women.…”

Section: Medical Risks Of Drinking For Women Compared With Mencontrasting

confidence: 46%

“…142 Several other epidemiologic studies have also suggested that heavy alcohol consumption may be associated with increased bone mineral density in postmenopausal women. [143][144][145][146] In the Framingham study, postmenopausal women who drank more than about 14 drinks per week had significantly increased bone mineral density. 143 Despite limitations in this study (women who drank more alcohol also tended to be taking hormone replacement therapy, and the method for measuring bone mineral density was not described), other studies have also observed increased bone density in women who drink.…”

Section: Medical Risks Of Drinking For Women Compared With Menmentioning

confidence: 99%

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Medical risks for women who drink alcohol

et al. 1998

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OBJECTIVE:To summarize for clinicians recent epidemiologic evidence regarding medical risks of alcohol use for women.METHODS: MEDLINE and PsychINFO, 1990 through 1996, were searched using key words "women" or "woman," and "alcohol." MEDLINE was also searched for other specific topics and authors from 1980 through 1996. Data were extracted and reviewed regarding levels of alcohol consumption associated with mortality, cardiovascular disease, alcoholrelated liver disease, injury, osteoporosis, neurologic symptoms, psychiatric comorbidity, fetal alcohol syndrome, spontaneous abortion, infertility, menstrual symptoms, breast cancer, and gynecologic malignancies. Gender-specific data from cohort studies of general population or large clinical samples are primarily reviewed. MAIN RESULTS:Women develop many alcohol-related medical problems at lower levels of consumption than men, probably reflecting women's lower total body water, gender differences in alcohol metabolism, and effects of alcohol on postmenopausal estrogen levels. Mortality and breast cancer are increased in women who report drinking more than two drinks daily. Higher levels of alcohol consumption by women are associated with increased menstrual symptoms, hypertension, and stroke. Women who drink heavily also appear to have increased infertility and spontaneous abortion. Adverse fetal effects occur after variable amounts of alcohol consumption, making any alcohol use during pregnancy potentially harmful. CONCLUSIONS:In general, advising nonpregnant women who drink alcohol to have fewer than two drinks daily is strongly supported by the epidemiologic literature, although specific recommendations for a particular woman should depend on her medical history and risk factors. L ess than three quarters of women in the UnitedStates drink alcohol, and those who do drink consume fewer drinks and less absolute alcohol than men. 1 However, at similar levels of self-reported alcohol consumption, the risk of psychosocial problems or dependence is greater for women than men (for definitions, see Appendix A). [2][3][4][5][6] Women also appear to develop alcohol abuse and dependence after fewer years of drinking than men. 7 Although only 4% to 5% of women in the U.S. general population meet criteria for past-year alcohol abuse or dependence, 8,9 9% of female primary care patients in some studies have reported recent heavy drinking or alcohol-related problems. 10,11 Many heavy drinkers decrease consumption following brief interventions that include explicit advice about safe drinking limits. [12][13][14] In addition, offering feedback about specific risks or consequences of their drinking to patients who drink heavily can help motivate them to decrease alcohol consumption or seek treatment. 15,16 Physicians report they would be more likely to advise patients about safe drinking practices if they were more confident of their knowledge about safe levels of alcohol consumption. 17 Women who drink more than two drinks daily on average, or who frequently drink five or more d...

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Section: Medical Risks Of Drinking For Women Compared With Mencontrasting

confidence: 46%

Section: Medical Risks Of Drinking For Women Compared With Menmentioning

confidence: 99%

Medical risks for women who drink alcohol

et al. 1998

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“…Consoante Hill et al 5 , a gordura proveniente da dieta é considerada determinante primária de obesidade, sendo esta mais prevalente em mulheres a partir do climatério 6 . Outros estudos revelam deficiência de nutrientes, como as vitaminas A e C 4,7 , o cál-cio 2,[8][9][10] e o ferro 4 .…”

Section: Introductionunclassified

Avaliação do estado nutricional e do consumo alimentar de mulheres no climatério

Montilla¹,

Marucci²,

Aldrighi³

2003

Rev. Assoc. Med. Bras.

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RESUMO -OBJETIVO. Avaliar o estado nutricional e o consumo INTRODUÇÃOVários agravos à saúde constatados no climatério relacionam-se, na maioria das vezes, direta ou indiretamente com a ingestão inadequada de alimentos, quer seja em excesso ou deficiência por longos períodos; essa inadequação, por sua vez, constitui em importante fator de risco 1 para inúmeras doenças, tais como as cardiovasculares, a obesidade, a osteoporose, o câncer de cólon e de mama 2,3,4 .No caso específico da mulher climatérica, os excessos nutricionais relacionam-se com o alto consumo de alimentos energéticos, principalmente provenientes de gorduras saturadas 2,3 . Consoante Hill et al. 5 , a gordura proveniente da dieta é considerada determinante primária de obesidade, sendo esta mais prevalente em mulheres a partir do climatério 6 . Outros estudos revelam deficiência de nutrientes, como as vitaminas A e C 4,7 , o cál-cio 2,8-10 e o ferro 4 .A existência de poucos estudos sobre nutrição em mulheres climatéricas reforça a necessidade de avançar nesta investigação. De fato, a própria Organização Mundial de Saúde (OMS) 11 recomenda pesquisas nessa área, a fim de melhor conhecer possíveis relações entre distúrbios alimentares e agravos à saúde. Como ocorre um aumento da prevalência de doenças crônicas no climatério, torna-se importante identificar a realidade nutricional da mulher nesse período, uma vez que a nutrição adequada é primordial para assegurar a saúde. MÉTODOSTrata-se de estudo transversal, cuja população foi constituída por 154 mulheres matriculadas no Ambulatório de Saúde da Mulher Climatérica (ASMUC) do Centro de Saú-de-Escola "Geraldo de Paula Souza" da Faculdade de Saúde Pública da Universidade de São Paulo. Sendo o ASMUC um ambulatório de atendimento multiprofissional, todas as pacientes eram encaminhadas primeiramente à consulta médica, onde eram solicitados os exames necessários (dosagem hormonal, colesterol, triglicérides, glicemia, mamografia, densitometria óssea, etc). As mulheres entre 35 e 50 anos apresentavam ciclos menstruais num intervalo variável entre 24 e 38 dias; o grupo após a menopausa, constituí-

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“…However, others showed no significant association between alcohol intake and BMD (24)(25)(26)(27)(28) , and one reported a negative relationship between BMD at the lumbar spine and lifetime beer consumption (29) .…”

mentioning

confidence: 99%

Alcohol consumption and bone mineral density in elderly women

Sommer

Erkkilä

Järvinen

et al. 2012

Public Health Nutr.

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Objective: Findings regarding alcohol consumption and bone mineral density (BMD) in elderly women have been inconsistent. The objective of the present study was to explore the association of alcohol intake with BMD in elderly women. Design: This cohort study included women from the population-based Kuopio Osteoporosis Risk Factor and Prevention -Fracture Prevention Study (OSTPRE-FPS). Alcohol intake and potential confounders were assessed at baseline and after 3 years of follow-up using a lifestyle questionnaire. In addition, an FFQ was distributed in the third year to measure dietary intake, including alcohol. Women underwent BMD measurements at the femoral neck and lumbar spine at baseline and after 3 years of follow-up. Setting: Kuopio Province, Finland. Subjects: Three hundred elderly women (mean age 67?8 years) who provided both BMD measurements and FFQ data. Results: Alcohol consumption estimated from the FFQ and lifestyle questionnaire was significantly associated with BMD at both measurement sites after adjustment for potential confounders, including lifestyle and dietary factors (P , 0?05). Using the FFQ, women drinking .3 alcoholic drinks/week had significantly higher BMD than abstainers, 12?0 % at the femoral neck and 9?2 % at the lumbar spine. Results based on the lifestyle questionnaire showed higher BMD values for all alcohol-consuming women at the femoral neck and for women drinking 1-3 alcoholic beverages/week at the lumbar spine, compared with non-users. Conclusions:The results from OSTPRE-FPS suggest that low to moderate alcohol intake may exert protective effects on bone health in elderly women.

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Determinants of bone density in normal women: risk factors for future osteoporosis?

Cited by 387 publications

References 24 publications

Medical risks for women who drink alcohol

Medical risks for women who drink alcohol

Avaliação do estado nutricional e do consumo alimentar de mulheres no climatério

Alcohol consumption and bone mineral density in elderly women

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