Determinants of breast cancer in Ethiopia: a systematic review and meta-analysis

Solbana, Lencho Kajela; Chaka, Eshetu Ejeta

doi:10.3332/ecancer.2023.1624

Cited by 2 publications

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“…In Ethiopia breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women, with an estimated 15,244 newly diagnosed cases and 8159 deaths in 2018 [4]. The most commonly identified risk factors for the occurrence of breast cancer in Ethiopia were family history of breast cancer, early menarche, being in postmenopause, and not ever breast feed [5].…”

Section: Introductionmentioning

confidence: 99%

Advanced-stage breast cancer diagnosis and its determinants in Ethiopia: a systematic review and meta-analysis

Zewdie,

Kassie,

Anagaw

et al. 2024

BMC Women's Health

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Introduction Worldwide, breast cancer is the primary cause of illness and death. Unless early detected and treated breast cancer is a life-threatening tumor. Advanced-stage presentation is greatly linked with short survival time and increased mortality rates. In Ethiopia nationally summarized evidence on the level of advanced-stage breast cancer diagnosis is scarce. Therefore, this systematic review and meta-analysis aimed to determine the pooled prevalence of advanced-stage breast cancer diagnosis and its determinants in Ethiopia. Method By following PRISMA guidelines, a systematic review and meta-analysis were carried out. To include relevant publications, a broad literature search was conducted in the African Online Journal, PubMed, Google Scholar, and Embase which are published until last search date; June 15, 2023. To prevent further duplication this review was registered in PROSPERO database with ID no of CRD42023435096. To determine the pooled prevalence, a weighted inverse variance random effect model was applied. I2 statistics and the Cochrane Q-test were computed to determine heterogeneity. To evaluate publication bias, a funnel plot, and Egger’s regression test were used. Result A total of 924 articles were sought and finally 20 articles were included in this review. The pooled prevalence of advanced-stage breast cancer diagnosis in Ethiopia was 72.56% (95%CI; 68.46-76.65%). Use of traditional medicine as first choice (AOR = 1.32, 95% CI: (1.13–1.55)), delay of > 3 months in seeking care (AOR = 1.24, 95% CI: (1.09–1.41)), diagnosis or health system delay of > 2 months (AOR = 1.27, 95% CI: (1.11–1.46)), rural residence (AOR = 2.04, 95% CI: (1.42 − 2.92)), and chief complaint of a painless breast lump (AOR = 2.67, 95% CI: (1.76–4.06)) were significantly associated to advanced-stage diagnosis. Conclusion In Ethiopia, more than two-thirds of breast cancer cases are diagnosed at an advanced stage. Use of traditional medicine before diagnostic confirmation, delay in seeking care, health system delay, rural residence, and chief complaint of painless breast lump were positively associated with an advanced-stage diagnosis. Policymakers and program designers give great focus to those delays so as to seek and access modern diagnosis and treatment as early as possible specifically focusing on those who are rurally residing.

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Section: Introductionmentioning

confidence: 99%

Advanced-stage breast cancer diagnosis and its determinants in Ethiopia: a systematic review and meta-analysis

Zewdie,

Kassie,

Anagaw

et al. 2024

BMC Women's Health

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Breast cancer and its determinants in Ethiopia: a systematic review and meta-analysis

Shama,

Terefa,

Desisa

et al. 2024

BMJ Open

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ObjectivesBreast cancer is the leading cause of cancer morbidity and mortality among women. Still, there is a paucity of studies to know the magnitude of the problem in Ethiopia. Hence, this review was intended to pool the prevalence and identify the determinants of breast cancer in Ethiopia.DesignA systematic review and meta-analysis was conducted.Data sourcesDatabases like PubMed/MEDLINE, HINARI, Science Direct, and Google Scholar, as well as websites of organisationsI organizations,rewere searched between 25 February and 6 March 2023.Eligibility criteriaAll observational studies in Ethiopia that reported either the magnitude and/or determinants of breast cancer regardless of publication status were included.Data extraction and synthesisTwo authors independently assessed and extracted the data. The Joanna Briggs Institute meta-analysis of statistics assessment and review instrument quality appraisal tool was used to assess the quality of the articles. Effect estimates were done by using the random-effects model. The meta-analysis results were displayed by using forest plots.ResultsSeventeen articles were reviewed with 24 435 total participants. The pooled proportion of breast cancer morbidity among patients with cancer was 20. 58% (95% CI 17.25%, 23.90%) in Ethiopia. Consuming packed foods (POR=2.12, 95% CI 1.41, 3.17), presence of high cholesterol (POR=4.08; 95% CI 2.75, 6.07), physical inactivity (POR=3.27; 95% CI 1.80, 5.94), high body mass index (BMI) (POR=2.27; 95% CI 0.85, 6.03), postmenopause (POR=2.25; 95% CI 1.63, 3.10), family history of cancer (POR=3.65; 95% CI 0.85, 15.71) and lack of breastfeeding (POR=2.76; 95% CI 0.90, 7.92) were the determinants of breast cancer.ConclusionsOne of five patients with cancer is diagnosed with breast cancer in Ethiopia. Furthermore, more than a quarter of women with cancer suffer from breast cancer. Processed food consumption, high cholesterol in the body, lack of physical activity, high BMI, postmenopause, family history of cancer and lack of breastfeeding were the risk factors for breast cancer. The use of healthy food sources such as fruits and vegetables, and homegrown varieties of crops rather than seeking processed foods would help.PROSPERO registration numberCRD42023417733

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Determinants of breast cancer in Ethiopia: a systematic review and meta-analysis

Cited by 2 publications

References 32 publications

Advanced-stage breast cancer diagnosis and its determinants in Ethiopia: a systematic review and meta-analysis

Advanced-stage breast cancer diagnosis and its determinants in Ethiopia: a systematic review and meta-analysis

Breast cancer and its determinants in Ethiopia: a systematic review and meta-analysis

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