Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings

Haque, Ahshanul; Platts-Mills, James A; Mduma, Estomih; Bodhidatta, Ladaporn; Bessong, Pascal; Shakoor, Sadia; Kang, Gagandeep; Kosek, Margaret; Lima, Aldo A. M.; Shrestha, Sanjaya; Alam, Ashraful; Havt, Alexandre; Samie, Amidou; Guerrant, Richard L.; Lang, Dennis; Mahfuz, Mustafa; Bhutta, Zulfiqar A; Houpt, Eric R.; Ahmed, Tahmeed

doi:10.1038/s41598-019-53533-3

Cited by 33 publications

(51 citation statements)

References 30 publications

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“…1 ). Several pathogens identified among the rhesus macaques are associated with human growth stunting and include Campylobacter 8 – 10 , 28 – 30 , Shigella 29 , 31 , enterotoxigenic Escherichia coli (ETEC) 28 , 29 , Cryptosporidium 29 , 31 , Entamoeba histolytica 32 , 33 , and Giardia 29 , 34 . Although diarrheal disease is relatively common among outdoor-housed non-human primates (NHP) 16 – 18 , 27 , none of the 1-month-old infants ( n = 80) presented with clinical diarrhea at the time of screening for enteric pathogens.…”

Section: Resultsmentioning

confidence: 99%

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

et al. 2022

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Environmental enteric dysfunction is associated with malnutrition as well as infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, and inflammation in the small intestine. Here, we characterized environmental enteric dysfunction among infant rhesus macaques that are naturally exposed to enteric pathogens commonly linked to human growth stunting. Remarkably, despite villous atrophy and histological abnormalities observed in the small intestine, poor growth trajectories and low serum tryptophan levels were correlated with increased histopathology in the large intestine. This work provides insight into the mechanisms underlying this disease and indicates that the large intestine may be an important target for therapeutic intervention.

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Section: Resultsmentioning

confidence: 99%

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

et al. 2022

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“…Low maternal MUAC was defined as a MUAC < 23 cm, which correlates closely with low BMI (Ghosh et al, 2019;Sultana et al, 2015). Length-for-age (LAZ), weight-for-age (WAZ) and weight-for-length (WLZ) Z scores were calculated as indicators of child nutritional status according to the 2006 WHO Standards For Children, using Z-score scale = (observed value À average value of the reference population)/standard deviation value of reference population (Haque et al, 2019;Onis & Bloessner, 1997).…”

Section: Variables Of Interestmentioning

confidence: 99%

Determinants of maternal low mid‐upper arm circumference and its association with child nutritional status among poor and very poor households in rural Bangladesh

Haque

Choudhury

Farzana

et al. 2021

Maternal & Child Nutrition

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Malnutrition among women is a long-standing public health concern that has significant adverse consequences on the survival and healthy development of children. Maternal mid-upper arm circumference (MUAC) could potentially represent a simpler alternative to traditional nutritional indicators. This study aimed to investigate the factors associated with low maternal MUAC (as an indicator of being underweight) and address the research question of whether maternal MUAC is significantly associated with children's nutritional status among poor and very poor households in rural Bangladesh. Data on 5,069 households were extracted from the Suchana programme baseline survey, which was carried out in 80 randomly selected unions (the lowest administrative unit of Bangladesh) in Sylhet and Moulvibazar districts between November 2016 and February 2017. The outcome variables were three child nutritional status indicators: wasting, stunting and underweight. Mothers were classified as underweight if their MUAC was less than 23 cm. Separate multiple logistic regression analyses were used to determine the factors potentially associated with maternal underweight status and explore whether maternal underweight status is significantly associated with children's nutritional status. The prevalence of maternal underweight status was 46.7%, and the prevalence of wasting, stunting and underweight among children under two were 10.5%, 44.4% and 31.9%, respectively.After controlling for various socio-economic and demographic characteristics, maternal MUAC was significantly associated with children's nutritional status in rural Bangladesh.

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“…We found higher maternal education was protective for aaiC and Aar genomic strain of EAEC. Findings from several other studies conducted in the MAL-ED settings also found an association of these factors with EAEC and Campylobacter infection 31 , 32 .…”

Section: Discussionmentioning

confidence: 57%

Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children

Das

Palit

Haque

et al. 2021

Sci Rep

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There is a lack of information highlighting the possible association between strain carrying genes of enteroaggregative Escherichia coli (EAEC) and environmental enteric dysfunction (EED) and on linear growth during childhood. Strain carrying genes of EAEC from stool samples collected from 1705 children enrolled in the MAL-ED birth cohort were detected by TaqMan Array Cards. We measured site-specific incidence rate by using Poisson regression models, identified the risk factors and estimated the associations of strain carrying genes of EAEC with the composite EED score and linear growth at 24 months of age. Overall highest incidence rate (43.3%) was found among children having infection with the aggR gene, which was the greatest in Tanzania (56.7%). Low maternal education, lack of improved floor, and ownership of domestic cattle were found to be risk factors for EAEC infection. In the multivariate models, after adjusting the potential covariates, strain carrying genes of EAEC showed strong positive associations with the EED scores and with poor linear growth at 24 months of age. Our analyses may lay the cornerstone for a prospective epidemiologic investigation for a potential vaccine development aimed at reducing the burden of EAEC infections and combat childhood malnutrition.

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Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings

Cited by 33 publications

References 30 publications

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

Determinants of maternal low mid‐upper arm circumference and its association with child nutritional status among poor and very poor households in rural Bangladesh

Site specific incidence rate of virulence related genes of enteroaggregative Escherichia coli and association with enteric inflammation and growth in children

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