Determinants of Cancer-Related Fatigue among Cancer Patients: A Systematic Review

Dsilva, Fatima; Singh, Payal; Javeth, Athar

doi:10.1177/08258597221131133

Cited by 10 publications

(3 citation statements)

References 101 publications

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“…Meanwhile, Chinese women are more tolerant and often hide their fatigue performance to avoid burdening their families, mistakenly believing that fatigue is only temporary. However, studies have shown[ 18 ] that persistent CRF leads to a higher risk of death. The findings of this research demonstrated that after the intervention, the observation group’s PFS-R scale scores on each dimension and overall were lower than the control group.…”

Section: Discussionmentioning

confidence: 99%

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

Ren,

Cui,

2023

World J Psychiatry

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Deep transcranial magnetic stimulation (DTMS) is a new non-invasive neuromodulation technique based on repetitive transcranial magnetic stimulation technology. The new H-coil has significant advantages in the treatment and mechanism research of psychiatric and neurological disorders. This is due to its deep stimulation site and wide range of action. This paper reviews the clinical progress of DTMS in psychiatric and neurological disorders such as Parkinson’s disease, Alzheimer’s disease, post-stroke motor dysfunction, aphasia, and other neurological disorders, as well as anxiety, depression, and schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

Ren,

Cui,

2023

World J Psychiatry

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“…In our study severe fatigue was already present at baseline and significantly worsened over time. Many factors (modifiable and non-modifiable) have been identified to affect cancerrelated fatigue [21]. Particularly for patients with advanced cancer, earlier intervention (i.e., during systemic therapy) is needed and cognitive behavioral therapy or physical exercise programs during systemic therapy have shown to reduce the severity of cancer-related fatigue [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Long-term health-related quality of life in patients with advanced esophagogastric cancer receiving first-line systemic therapy

Pape

Vissers

Slingerland

et al. 2023

Support Care Cancer

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Purpose To investigate the effect of systemic therapy on health-related quality of life (HRQoL) in patients with advanced esophagogastric cancer in daily clinical practice. This study assessed the HRQoL of patients with esophagogastric cancer during first-line systemic therapy, at disease progression, and after progression in a real-world context. Methods Patients with advanced esophagogastric cancer (2014–2021) receiving first-line systemic therapy registered in the Prospective Observational Cohort Study of Oesophageal-gastric cancer (POCOP) were included (n = 335). HRQoL was measured with the EORTC QLQ-C30 and QLQ-OG25. Outcomes of mixed-effects models were presented as adjusted mean changes. Results Results of the mixed-effect models showed the largest significant improvements during systemic therapy for odynophagia (− 18.9, p < 0.001), anxiety (− 18.7, p < 0.001), and dysphagia (− 13.8, p < 0.001) compared to baseline. After progression, global health status (− 6.3, p = 0.002) and cognitive (− 6.2, p = 0.001) and social functioning (− 9.7, p < 0.001) significantly worsened. At and after progression, physical (− 9.0, p < 0.001 and − 8.8, p < 0.001) and role functioning (− 15.2, p = 0.003 and − 14.7, p < 0.001) worsened, respectively. Trouble with taste worsened during systemic therapy (11.5, p < 0.001), at progression (12.0, p = 0.004), and after progression (15.3, p < 0.001). Conclusion In general, HRQoL outcomes in patients with advanced esophagogastric cancer improved during first-line therapy. Deterioration in outcomes was mainly observed at and after progression. Implications for cancer survivors Identification of HRQoL aspects is important in shared decision-making and to inform patients on the impact of systemic therapy on their HRQoL.

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“…Previous reports have indicated that several factors, including anemia, insomnia, anxiety, and depression, are essential for the occurrence and development of fatigue in patients with cancer (19)(20)(21).…”

Section: Risk Factorsmentioning

confidence: 99%

Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023

Li,

Wang,

Feng

et al. 2024

Front. Oncol.

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ObjectiveCancer seriously endangers human health and represents a global public health issue. Cancer-related fatigue (CRF) is a distressing and persistent sense of exhaustion caused by cancer or cancer treatment, widely prevalent among cancer patients. This study aims to summarize emerging trends and provide directions for future research of CRF through bibliometric and visualization analyses.MethodsA systematic search in the Web of Science Core Collection database from 2001-01-01 to 2023-05-18 were conducted. Only reviews and articles written in English were considered. CiteSpace and the R were used for bibliometric and visualization analyses.ResultsThe analysis revealed that 2,566 studies on CRF have been published by 1,041 institutions in 70 countries so far. The number of articles published and cited annually have been steadily increasing. Eduardo Bruera published the most articles, and Julienne E Bower is the most co-cited author. The University of Texas System is the leading institution in cancer-related fatigue research. The United States and China have the largest number of publications. Supportive Care in Cancer published the most articles, and Journal of Clinical Oncology is the most co-cited journal. “Comparison of Pharmaceutical, Psychological, and Exercise Treatments for Cancer-Related Fatigue: A Meta-analysis”, authored by Mustian KM et al. and published in JAMA Oncology was the most co-cited document. Keyword analysis indicated that research focus had shifted from “epoetin alpha” and “anemia” to “risk factors”, “systematic review”, “acupuncture”, “anxiety”, “traditional Chinese medicine” and “guidelines”.ConclusionIn conclusion, this analysis provides comprehensive research trends and knowledge network maps of CRF. Clinical physicians should concurrently focus on the anemia, insomnia, anxiety, and depression status of patients when assessing or managing CRF. Improvements in related risk factors also contribute to alleviating fatigue. Furthermore, it is essential to pay attention to authoritative CRF guidelines. Acupuncture and traditional Chinese medicine also have therapeutic potential, which merits further investigation. Researchers should draw attention to the crucial roles of inflammation, hypoxia, and mitochondrial dysfunction, which could be the frontiers.

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Determinants of Cancer-Related Fatigue among Cancer Patients: A Systematic Review

Cited by 10 publications

References 101 publications

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

Long-term health-related quality of life in patients with advanced esophagogastric cancer receiving first-line systemic therapy

Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023

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