Determinants of cerebral hemodynamics during the Trail Making Test in schizophrenia

Schuepbach, Daniel; Egger, Stephan; Boeker, Heinz; Duschek, Stefan; Vetter, Stefan; Seifritz, Erich; Herpertz, Sabine C.

doi:10.1016/j.bandc.2016.09.002

Cited by 11 publications

(10 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several of these neuroanatomical areas are also involved in psychopathology and the neurocognitive anomalies related to schizophrenia (14,41). Studies (including ours) using fTCD demonstrate a correlation between performance and hemodynamic patterns (14)(15)(16). This lends support to the view that factors inherent to schizophrenia as well as to other conditions characterized by executive dysfunction, such as dysfunctional neuronal integrity, accelerated white matter aging, hypoperfusion and increased vascular resistance (42)(43)(44)(45) may play a role.…”

Section: Discussionsupporting

confidence: 77%

“…Previous findings also report a positive correlation between the TMT-B and hemodynamic activity in the MCA; this may be due to activation of the DLPFC, temporal cortex, basal ganglia and the thalamus during the TMT-B (17,18). Several of these neuroanatomical areas are also involved in psychopathology and the neurocognitive anomalies related to schizophrenia (14,41). Studies (including ours) using fTCD demonstrate a correlation between performance and hemodynamic patterns (14)(15)(16).…”

Section: Discussionsupporting

confidence: 66%

“…Thirty patients fulfilling the WHO-ICD 10 (21) criteria for schizophrenia participated in this study; they were age and sex-matched with 15 healthy controls. The healthy controls had no medical, neurological or psychiatric condition at the time of examination; they were recruited for a previous study conducted by our research group, using the same examination protocol and equipment (14). All participants were right-handed.…”

Section: Subjectsmentioning

confidence: 99%

“…However, TCD has low anatomical resolution and is not able to deliver a direct brain image. Despite this limitation, TCD has been used to study physiological and hemodynamic conditions in several neurological diseases and psychiatric disorders (11,13,14). The neurocognitive impairment in schizophrenia appears to be related to alterations in blood flow in several brain areas, including the DLPFC (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…A number of these structures, principally the DLPFC, striatum and thalamus, are activated during the TMT (17), making fTCD a suitable method for the physiological and hemodynamic assessment of brain activity in these areas during a neurocognitive task (20). Previous studies using functional TCD (fTCD) in patients with schizophrenia and healthy controls showed clear differences in the MCA hemodynamic pattern during the TMT (14); to what extent there are also hemodynamic differences between those affected with schizophrenia, in relation to the number and severity of symptoms (i.e., symptom load) is thus far unexplored.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Psychopathological Symptom Load and Distinguishable Cerebral Blood Flow Velocity Patterns in Patients With Schizophrenia and Healthy Controls: A Functional Transcranial Doppler Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction: Schizophrenia is a severe psychiatric disorder, with executive dysfunction and impaired processing speed playing a pivotal role in the course of the disease. In patients with schizophrenia, neurocognitive deficits appear to be related to alterations in cerebral hemodynamics. It is not fully understood if psychopathological symptom load (i.e., presence and severity of symptoms) is also related to alterations in cerebral hemodynamics. We aim to study the relationship between psychopathological symptom load and cerebral hemodynamics in the Middle Cerebral Artery (MCA) during a cognitive task in patients with schizophrenia and healthy controls.Methodology: Cerebral hemodynamics in the MCA were examined in 30 patients with schizophrenia and 15 healthy controls using functional Transcranial Doppler (fTCD) during the Trail Making Test (TMT). Psychopathological symptoms were measured using the Brief Psychiatric Rating Scale (BPRS). Patients were dichotomized according to BPRS scores: mild-moderate (BPRS < 41, n = 15) or marked-severe (BPRS ≧ 41, n = 15). Mean blood flow velocity (MFV) in the MCA and processing speed of the TMT were analyzed. Cerebral hemodynamics were analyzed using the general additional model (GAM) with a covariate analysis of variance (ANCOVA) for group comparisons.Results: Patients and healthy controls were comparable regarding demographics. Patients had a slower processing speed for the TMT-A (patients-severe: 52s, patients-moderate: 40s, healthy-controls: 32s, p = 0.019) and TMT-B [patients-severe: 111s, patients-moderate: 76s, healthy-controls: 66s, p < 0.001)]. Patients demonstrated differing hemodynamic profiles in both TMTs: TMT- A [F(6, 1,792) = 17, p < 0.000); TMT-B [F(6, 2,692) = 61.93, p < 0.000], with a delay in increase in MFV and a failure to return to baseline values.Conclusions: Patients with schizophrenia demonstrated slower speeds of processing during both the TMT-A and TMT-B. The speed of processing deteriorated with increasing psychopathological symptom load, additionally a distinct cerebral hemodynamic pattern in the MCA was observed. Our results further support the view that severity of schizophrenia, particularly psychopathological symptom load, influences performance in neurocognitive tasks and is related to distinct patterns of brain hemodynamics.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 66%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Psychopathological Symptom Load and Distinguishable Cerebral Blood Flow Velocity Patterns in Patients With Schizophrenia and Healthy Controls: A Functional Transcranial Doppler Study

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Functional transcranial Doppler: Selection of methods for statistical analysis and representation of changes in flow velocity

Egger

Bobes

Seifritz

et al. 2021

Health Science Reports

Self Cite

View full text Add to dashboard Cite

Introduction Transcranial Doppler (TCD) is a method used to study cerebral hemodynamics. In the majority of TCD studies, regression analysis and analysis of variance are the most frequently applied statistical methods. However, due to the dynamic and interdependent nature of flow velocity, nonparametric tests may allow for better statistical analysis and representation of results. Method The sample comprised 30 healthy participants, aged 33.87 ± 7.48 years; with 33% (n = 10) females. During a visuo‐motor task, the mean flow velocity (MFV) in the middle cerebral artery (MCA) was measured using TCD. The MFV was converted to values relative to the resting state. The results obtained were analyzed using the general linear model (GLM) and the general additional model (GAM). The fit indices of both analysis methods were compared with each other. Results Both MCAs showed a steady increase in MFV during the visuo‐motor task, smoothly returning to resting state values. During the first 20 seconds of the visuo‐motor task, the MFV increased by a factor of 1.06 ± 0.07 in the right‐MCA and by a factor of 1.08 ± 0.07 in the left‐MCA. GLM and GAM showed a statistically significant change in MFV (GLM:F(2, 3598) = 16.76, P < .001; GAM:F(2, 3598) = 21.63, P < .001); together with effects of hemispheric side and gender (GLM:F(4, 3596) = 7.83, P < .005; GAM:F(4, 3596) = 2.13, P = .001). Comparing the models using the χ2 test for goodness of fit yields a significant difference χ2 (9.9556) = 0.6836, P < .001. Conclusions Both the GLM and GAM yielded valid statistical models of MFV in the MCA in healthy subjects. However, the model using the GAM resulted in improved fit indices. The GAM's advantage becomes even clearer when the MFV curves are visualized; yielding a more realistic approach to brain hemodynamics, thus allowing for an improvement in the interpretation of the mathematical and statistical results. Our results demonstrate the utility of the GAM for the analysis and representation of hemodynamic parameters.

show abstract

Cerebral blood flow responses during prosaccade and antisaccade preparation in major depression

Hoffmann

Montoro

Paso

et al. 2018

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Determinants of cerebral hemodynamics during the Trail Making Test in schizophrenia

Cited by 11 publications

References 58 publications

Psychopathological Symptom Load and Distinguishable Cerebral Blood Flow Velocity Patterns in Patients With Schizophrenia and Healthy Controls: A Functional Transcranial Doppler Study

Psychopathological Symptom Load and Distinguishable Cerebral Blood Flow Velocity Patterns in Patients With Schizophrenia and Healthy Controls: A Functional Transcranial Doppler Study

Functional transcranial Doppler: Selection of methods for statistical analysis and representation of changes in flow velocity

Cerebral blood flow responses during prosaccade and antisaccade preparation in major depression

Contact Info

Product

Resources

About