Why was it set up? Since the early 2000s, India has made significant strides in the health sector, as indicated by major reductions in infant mortality and maternal mortality rates. (1-4) Yet, the country struggles in addressing chronic diseases, nutritional deficiencies, newborn health outcomes, women's health issues, and sexually transmitted and blood-borne infection (STBBI) rates. A large challenge in addressing these health outcomes is the lack of access to quality healthcare among vulnerable and remote populations, such as rural and tribal communities, especially considering that the vast majority of Indians live in rural areas. (5,6) In an effort to address health disparities in rural areas, the Kisalaya ("young tender shoots") Cohort was established in 2008, providing integrated antenatal care and HIV testing in order to reduce adverse birth outcomes and pediatric HIV infections. The program used a mobile clinic model to deliver health education, antenatal care, and HIV/STI testing and management to pregnant women in 144 rural villages in Mysuru Taluk of Mysuru district (Figure 1). The mother-offspring dyads were followed-up at 15 days and 6 months post-delivery. The study team continues to stay connected to the dyads informally on a regular basis. This cohort design allows investigators to monitor how access to comprehensive prenatal and HIV services impacts postnatal health outcomes for both women and children over time. The rich data pertaining to maternal and child health will be used in our future research related to the developmental origins of health and disease (DOHaD) of cognition and cardiometabolic risk factors among the offspring.