Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways

Aliee, Hananeh; Massip, Florian; Qi, Cancan; Biase, Maria Stella de; Nijnatten, Jos van; Kersten, Elin T.G.; Kermani, Nazanin Zounemat; Khuder, Basil; Vonk, Judith M.; Vermeulen, Roel; Neighbors, Margaret; Tew, Gaik W.; Grimbaldeston, Michele A.; Hacken, Nick H. T. ten; Hu, Sile; Guo, Yike; Zhang, Xiaoyu; Sun, Kai; Hiemstra, Pieter S.; Ponder, Bruce A.J.; Mäkelä, Mika; Malmström, Kristiina; Rintoul, Robert C.; Reyfman, Paul A.; Theis, Fabian J.; Brandsma, Corry‐Anke; Adcock, Ian M.; Timens, Wim; Xu, Cheng‐Jian; Berge, Maarten van den; Schwarz, Roland F.; Koppelman, Gerard H.; Nawijn, Martijn C.; Faiz, Alen

doi:10.1111/all.15152

Cited by 22 publications

(16 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 57 It was mentioned that SARS‐CoV‐2 cell entry factor (SCEF) is important for the entrance of COVID‐19 virus to the upper airway epithelium, while in smokers it was also shown that SARS‐CoV‐2 can easily penetrate both the upper and lower airways epithelium. 58 Moreover, a significant positive correlation between COVID‐19 infection and airborne pollen concentration was reported by Damialis et al The authors have mentioned that the interaction of the coronavirus and pandemic viruses with similar potential in the future may be exacerbated by the increased abundances of airborne pollen, because pollen exposure weakens antiviral immune response. 59 The association between climate change and infectious disease is well established, but burden of the effects and affected pathogens remain under‐studied.…”

Section: Global Warming Climate Change and Exposomementioning

confidence: 92%

“…It is even claimed that climate change may have played a pivotal role in the emergence of COVID‐19 by forcing species to change their habitats and their geographic range, and serving as a tool to bring wild animals closer to humans and farm animals 57 . It was mentioned that SARS‐CoV‐2 cell entry factor (SCEF) is important for the entrance of COVID‐19 virus to the upper airway epithelium, while in smokers it was also shown that SARS‐CoV‐2 can easily penetrate both the upper and lower airways epithelium 58 . Moreover, a significant positive correlation between COVID‐19 infection and airborne pollen concentration was reported by Damialis et al The authors have mentioned that the interaction of the coronavirus and pandemic viruses with similar potential in the future may be exacerbated by the increased abundances of airborne pollen, because pollen exposure weakens antiviral immune response 59 .…”

Section: Global Warming Climate Change and Exposomementioning

confidence: 99%

See 1 more Smart Citation

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

221

166

View full text Add to dashboard Cite

Environmental exposure plays a major role in the development of allergic diseases.The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects.Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic

show abstract

Section: Global Warming Climate Change and Exposomementioning

confidence: 92%

Section: Global Warming Climate Change and Exposomementioning

confidence: 99%

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

221

166

View full text Add to dashboard Cite

show abstract

“…In this study, PPI enrichment analysis showed that TMEM27 was a SLC6A20 -associated protein. TMEM27, a homologue of ACE2, has previously been reported as being co-regulated with ACE2 in bronchial samples . Given the prominent role of ACE2 in increased susceptibility in cancer patients and TMEM27 exhibiting 47% homology to ACE2 functions, we speculate that TMEM27 might be involved in the increased susceptibility in cancer patients for COVID-19.…”

Section: Discussionmentioning

confidence: 83%

Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20

Acar

2023

ACS Omega

View full text Add to dashboard Cite

Genome-wide association studies demonstrated that the chromosome 3p31.21 locus was linked to the severity of COVID-19 disease. The SLC6A20 gene was reported to be one of the critical causal genes regulated by this locus. Various studies focused on demonstrating the severity of COVID-19 in cancer patients and reported that elevated SARS-CoV-2-associated gene expression might contribute to increased susceptibility for COVID-19 in cancer patients. Given that pan-cancer association for the COVID-19 causal gene SLC6A20 is lacking, we aimed to perform systematic profiling of SLC6A20 in different malignancies. Human Protein Atlas, UALCAN, and Hepatocellular Carcinoma (HCCDB) databases were used to assess SLC6A20 gene expression changes in The Cancer Genome Atlas samples with respect to their normal counterparts. GEPIA and TIMER2.0 databases were used to determine the correlation between SLC6A20 and COVID-19-associated genes. Different databases were used for identification of the correlation of SCL6A20 with infiltrating immune cells. The canSAR database was utilized to determine the association of SCL6A20 with immune profiling in different malignancies. The STRING database was utilized to determine the protein network interacting with SLC6A20. Here, we showed SLC6A20 mRNA expression in pan-cancer samples and their normal counterparts. Increased SCL6A20 expression was associated with tumor grade, and there was a positive correlation with SARS-CoV-2-associated genes. Furthermore, SLC6A20 expression was positively correlated with infiltrating neutrophils and immune-related signatures. Lastly, SLC6A20 expression was found to be associated with the angiotensin converting enzyme 2 homologue, TMEM27, suggesting a potential link between SLC6A20 and COVID-19. Taken together, these results suggest that elevated SLC6A20 levels might be partly responsible for increased susceptibility of cancer patients to COVID-19 disease. Therapeutic intervention strategies against SLC6A20 in cancer patients, alongside other treatment modalities, might offer a benefit in delaying COVID-19 disease.

show abstract

“…Cellular deconvolution of bulk RNA-seq data was performed to estimate the proportions of different cell types from the gene expression for all bulk RNA-Seq datasets [ 10 ], as described in the Additional file 1 .…”

Section: Methodsmentioning

confidence: 99%

Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental models of COPD, but differences between sources may impact on their potential use in therapeutic strategies in patients. Aim To assess the transcriptome of lung-derived MSCs (LMSCs), bone marrow-derived MSCs (BM-MSC) and adipose-derived MSCs (AD-MSCs) from COPD patients and non-COPD controls. Methods We studied differences in gene expression profiles between the MSC-subtypes, as well as between COPD and control using RNA sequencing (RNA-seq). Results We show that besides heterogeneity between donors, MSCs from different sources have strongly divergent gene signatures. The growth factors FGF10 and HGF were predominantly expressed in LMSCs. MSCs from all sources displayed altered expression profiles in COPD, with most pronounced significantly up- and downregulated genes in MSCs from adipose tissue. Pathway analysis revealed that the most differentially expressed genes in COPD-derived AD-MSCs are involved in extracellular matrix (ECM) binding and expression. In LMSCs, the gene that differed most strongly between COPD and control was CSGALNACT1, an ECM modulating gene. Conclusion Autologous MSCs from COPD patients display abnormalities with respect to their transcriptome, which were surprisingly most profound in MSCs from extrapulmonary sources. LMSCs may be optimally equipped for lung tissue repair because of the expression of specific growth factor genes.

show abstract

Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways

Cited by 22 publications

References 7 publications

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20

Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls

Contact Info

Product

Resources

About