This study employed the propensity score matching approach to empirically assess the effects of climate smart agriculture participation and climate change adaptation response on the technical efficiency of rice production. Observational data were collected from in-depth interviews with 352 rice farm households in the Mekong Delta, Vietnam. The findings indicate that 71% of local farmers adapted their rice farming to climate change related to salinity intrusion and drought, while 29% of farmers did not. Additionally, only twenty-two rice farmers were typically chosen as participants in the climate smart agriculture pilot program by local government and institutions. The choices for adaptation response and climate smart agriculture participation are significantly influenced by agricultural extension services, belief in climate change, the area of farming land, as well as geographical locations (e.g., province and access to water sources). The results also reveal that climate change adaptation response, including climate smart agriculture participation, played a crucial role in improving technical efficiency of rice production by 13%–14% compared to no adaptation response. Regarding the individual effect of climate smart agriculture participation, participants could achieve higher technical efficiency by 5%–8% compared to non-participants.