Determinants of Fatigue after First-Ever Ischemic Stroke during Acute Phase

Abstract

Background and PurposeFatigue after stroke is common and has a negative impact on rehabilitation and survival. However, its pathogenesis and contributing factors remain unclear. The purpose of this study was to identify factors influencing the occurrence of fatigue after first-ever ischemic stroke in acute phase.MethodsWe examined 265 consecutive patients with first-ever ischemic stroke during acute phase (within 2 weeks) in two tertiary stroke care hospitals in Henan, China. We documented patients’ demographic and clinical characteristics through face-to-face interviews using structured questionnaires and reviews of medical records. Post-stroke fatigue was defined as a score of ≥4 using the Fatigue Severity Scale. Multivariate logistic regression was used to examine post-stroke fatigue in relation to socio-demographic, lifestyle, clinical characteristics and family function.ResultsAbout 40% first-ever ischemic stroke patients experienced post-stroke fatigue in acute phase. Post-stroke fatigue was associated with lack of exercise before stroke (adjusted odds ratio 4.01, 95% CI 1.95–8.24), family dysfunction (2.63, 1.20–5.80), depression (2.39, 1.02–5.58), the presence of pre-stroke fatigue (4.89, 2.13–11.21), use of sedative medications (4.14, 1.58–10.88), coronary heart disease (3.38, 1.46–7.79) and more severe Modified Rankin Scale (2.55, 1.65–3.95).ConclusionsThe causes of post-stroke fatigue are multifaceted. More physical exercise, improving family function, reducing depression and appropriate use of sedative medications may be helpful in preventing post-stroke fatigue.

Determinants of Poststroke Fatigue among Stroke Survivors Undergoing Rehabilitation in Nigeria

“…While many of the previous studies that investigated the determinants of PSF have reported conflicting and inconclusive findings, the impact of level of functional ability (or disability) appears be fairly consistent across studies (4,15,17,22,23). A recent systematic review of PSF literature showed that 25 studies found a significant association between PSF and functional ability while 15 studies did not (4).…”

“…While findings are largely conflicting and apparently inconclusive (9), some studies have shown significant associations between PSF and demographic factors such as female gender (10-12) and older age (10,11,13). Similarly, there is some evidence that clinical factors such as functional ability and pre-stroke fatigue influence PSF (3,4,14,15).…”

“…While an overwhelming majority of data on determinants of PSF is from Asian and developed Western countries (3,(10)(11)(12)(13)(14)(15), there is a dearth of information on the subject in developing countries including African countries such as Nigeria. There is however a need for countryspecific data especially as there are reports on association between race/ethnicity and fatigue (16,17).…”

Characteristics Of Fatigue Post Stroke Patient’s

“…(2015) menjelaskan prevalensi tertinggi fatigue pada pasien post stroke bisa terjadi pada bulan ke tiga setelah serangan hal ini dikaitkan dengan umur dan jenis kelamin. Studi lain kejadian fatigue dapat terjadi selama fase akut (2 minggu) pada pasien post stroke iskemik dan hal ini dikaitkan dengan depresi, aktivitas sebelum stroke dan disfungsi keluarga (Wang, et al, 2014).…”

Neuroprotective mechanism of HIF-1α overexpression in the early stage of acute cerebral infarction in rats

“…Epidemiological survey results in recent years have demonstrated that cerebrovascular disease accounts for the second highest mortality rates in China, second only to malignant tumors (2). As for the survivors, ~75% of patients with cerebrovascular disease lose the capacity to work, to varying degrees and >40% may be severely disabled (3,4). Therefore, cerebrovascular disease is associated with high morbidity and mortality, causing serious harm to human health and quality of life.…”