Determinants of forward pulmonary vein flow

Barbier, P.; Solomon, Steve; Schiller, Nelson B.; Glantz, Stanton A.

doi:10.1016/s0735-1097(00)00642-2

Cited by 29 publications

(14 citation statements)

References 33 publications

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“…64,65,69 In addition, systolic LV function tends to parallel left atrial systolic performance. 37,65,69 This was particularly obvious with the inverse relationship between peak A and τ in this study. Impairment of relaxation because of LV myocardial disease causes an increase of late diastolic filling in the presence of preserved left atrial function (shift of filling from early to late diastole).…”

Section: Discussionmentioning

confidence: 51%

Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats

Schober

Fuentes²,

Bonagura³

2003

ajvr

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Section: Discussionmentioning

confidence: 51%

Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats

Schober

Fuentes²,

Bonagura³

2003

ajvr

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“…While previous studies have shown that VNS decreases ventricular fibrosis in dogs with infarct-induced HF, 20 this is the first study of the same phenomenon also occurring in atrial myocardium. Although worsened left atrial function and increased left atrial size can be expected due to worsening of LV function, 21 the impact of VNS was more pronounced on contractile rather than diastolic LA function. Moreover, our findings suggest that VNS affects negative LA strain (LA pump function) more than it does LV strain (LV systolic function).…”

Section: Discussionmentioning

confidence: 90%

Impact of Vagal Nerve Stimulation on Left Atrial Structure and Function in a Canine High-Rate Pacing Model

Kusunose

Zhang²,

Mazgalev

et al. 2014

Circ: Heart Failure

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Background Cervical vagal nerve stimulation (VNS) can improve left ventricular dysfunction in the setting of heart failure (HF). However, little is known about the impact of VNS on left atrial (LA) function. The aim of this study was to compare LA mechanics and histology between control and VNS-treated animals during HF development. Methods and Results Fifteen mongrel dogs were randomized into control (n=7) and VNS (n=8) groups. All dogs underwent 8 weeks of high-rate ventricular pacing (at 220bpm for the first 4 weeks to develop HF and another 4 weeks at 180bpm to maintain HF). LA contractile function (LA negative peak strain), conduit function (LA positive peak strain), and reservoir function (LA total strain) were measured from speckle tracking in two groups. At the end of the terminal study, the left atrial appendage was obtained. Baseline LA strains were comparable in the control and VNS treated dogs. At 4 and 8 weeks of ventricular pacing, all LA strains were decreased and LA volumes were increased in the control group compared with the VNS group (p <0.05). Histological evaluation of the LA revealed that percent fibrosis was significantly lower in the VNS vs. the control group (8±1% vs. 13±1%, p <0.001). Finally transmitral flow showed decreased atrial contribution to left ventricular filling in the control group (p <0.05). Conclusions VNS improved LA function and volumes and suppressed LA fibrosis in the canine high-rate ventricular pacing model. VNS is a novel and potentially useful therapy for improving LA function during HF.

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“…Other factors involved have been evaluated, such as left atrium relaxation and compliance and left ventricular function. [21][22][23][24][25][26][27] Pulmonary vein relaxation, mediated by C-type natriuretic peptide, is uniform and thus does not allow segmental variations. 28 The effects of vessel tapering in the pulmonary circulation have been studied by nonlinear models, 6,10 and the role of the vessel cross-sectional area in the flow wave dynamics has also been assessed.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of the Pulmonary Venous Flow in the Fetus and Its Association With Vascular Diameter

Zielinsky¹,

Piccoli²,

Gus³

et al. 2003

Circulation

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Background-The usual positioning of the Doppler sample volume to assess fetal pulmonary vein flow is in the distal portion of the vein, where the vessel diameter is maximal. This study was performed to test the association of the pulmonary vein pulsatility index (PVPI) with the vessel diameter. Methods and Results-Twenty-three normal fetuses (mean gestational age, 28.6Ϯ5.3 weeks) were studied by Doppler echocardiography. Pulmonary right upper vein flow was assessed adjacent to the venoatrial junction ("distal" position) and in the middle of the vein ("proximal" position). The vessel diameter was measured by 2D echocardiography with power Doppler, and the PVPI was obtained by the ratio (maximal velocity [systolic or diastolic peak]Ϫminimal velocity [presystolic peak])/mean velocity. The statistical analysis used t test and exponential correlation studies. Mean distal diameter was 0.33Ϯ0.10 cm (0.11 to 0.57 cm), and mean proximal diameter was 0.16Ϯ0.08 cm (0.11 to 0.25 cm) (PϽ0.0001). Mean distal PVPI was 0.84Ϯ0.21 (0.59 to 1.38), and mean proximal PVPI was 2.09Ϯ0.59 (1.23 to 3.11) (PϽ0.0001). Exponential inverse correlation between pulmonary vein diameter and pulsatility index was highly significant (PϽ0.0001), with a determination coefficient of 0.439. Conclusions-In the normal fetus, the pulmonary venous flow pulsatility decreases from the lung to the heart, and this parameter is inversely correlated to the diameter of the pulmonary vein, which increases from its proximal to its distal portion. This study emphasizes the importance of the correct positioning of the Doppler sample volume, adjacent to the venoatrial junction, to assess pulmonary venous flow dynamics.

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Determinants of forward pulmonary vein flow

Cited by 29 publications

References 33 publications

Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats

Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats

Impact of Vagal Nerve Stimulation on Left Atrial Structure and Function in a Canine High-Rate Pacing Model

Dynamics of the Pulmonary Venous Flow in the Fetus and Its Association With Vascular Diameter

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