Determinants of fructosamine levels in a multi-ethnic Sub-Saharan African population

Nouya, Audrey Yondjeu; Nansseu, Jobert Richie; Moor, Vicky Jocélyne Ama; Pieme, Constant Anatole; Noubiap, Jean Jacques; Tchoula, Corinne M.; Mokette, Bruno M.; Takam, Ruth Danielle M.; Tankeu, Francine Nzufo; Ngogang, Jeanne; Kengne, André Pascal

doi:10.1016/j.diabres.2014.09.042

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Nevertheless, since all correlations lost their significance after accounting for ppBMI, uncorrected fructosamine concentrations may be more associated with markers of overall adiposity (ppBMI, SAT) than with insulin levels and insulin resistance itself. Although, independently of ppBMI, second- and third-trimester fasting glucose concentrations were positively associated with fructosamine, confirming previously published data collected among pregnant [ 22 , 25 , 34 ] and non-pregnant populations [ 44 , 57 , 58 ]. The positive association between fructosamine and fasting blood glucose could be explained by the glycation mechanisms leading to the formation of fructosamine.…”

Section: Discussionsupporting

confidence: 89%

“…All associations observed between fructosamine and adipose tissue thicknesses were partially influenced by ppBMI. Other studies in the general population demonstrated inverse associations between uncorrected fructosamine and BMI, both in diabetic and non-diabetic samples [ 43 , 44 , 45 ]. Contrary to our results, a study investigating body fat distribution and glycemic control among Maya women in rural Yucatán demonstrated that variables reflecting overall adiposity and central adiposity were positively associated with fructosamine [ 53 ].…”

Section: Discussionmentioning

confidence: 98%

“…Even though the links between abdominal fat accumulation, adipose tissue dysfunction, adiposity-related systemic inflammation, and insulin resistance have been well demonstrated [ 41 , 42 ], no study has ever investigated the associations between fructosamine concentrations and abdominal adiposity or inflammation in pregnancy. Furthermore, even if BMI has been shown to strongly correlate with fructosamine concentrations [ 43 , 44 , 45 ] its confounding effects have never been studied in those associations. Thus, this study aims to (1) characterize the variations of fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI) categories and (2) examine associations between fructosamine concentrations (both uncorrected and corrected for albumin concentrations) and (a) adiposity (ppBMI, first-trimester subcutaneous (SAT) and visceral (VAT) adipose thicknesses, and leptin), (b) glucose homeostasis (fasting blood glucose, fasting blood insulin, and an insulin resistance index (HOMA-IR)) and (c) inflammation measurements (adiponectin, IL-6, and C-reactive protein (CRP) in each trimester, with and without adjustment for ppBMI.…”

Section: Introductionmentioning

confidence: 99%

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Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

et al. 2022

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This study aimed to (1) characterize the variations in serum fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI), and (2) examine associations between fructosamine and adiposity/metabolic markers (ppBMI, first-trimester adiposity, leptin, glucose homeostasis, and inflammation measurements) during pregnancy. Serum fructosamine, albumin, fasting glucose and insulin, leptin, adiponectin, interleukin-6 (IL-6), and C-reactive protein (CRP) concentrations were measured at each trimester. In the first trimester, subcutaneous (SAT) and visceral (VAT) adipose tissue thicknesses were estimated by ultrasound. In the 101 healthy pregnant individuals included (age: 32.2 ± 3.5 y.o.; ppBMI: 25.5 ± 5.5 kg/m2), fructosamine concentrations decreased during pregnancy whereas albumin-corrected fructosamine concentrations increased (p < 0.0001 for both). Notably, fructosamine concentrations were inversely associated with ppBMI, first-trimester SAT, VAT, and leptin (r = −0.55, r = −0.61, r = −0.48, r = −0.47, respectively; p < 0.0001 for all), first-trimester fasting insulin and HOMA-IR (r = −0.46, r = −0.46; p < 0.0001 for both), and first-trimester IL-6 (r = −0.38, p < 0.01). However, once corrected for albumin, most of the correlations lost strength. Once adjusted for ppBMI, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP (r = 0.24, r = 0.27; p < 0.05 for both). In conclusion, serum fructosamine is inversely associated with adiposity before and during pregnancy, with markers of glucose homeostasis and inflammation, but the latter associations are partially influenced by albumin concentrations and ppBMI.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

et al. 2022

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“…In persons without a history of diabetes, we found that cross-sectional risk factor associations for elevated fructosamine or glycated albumin were generally similar to those observed for elevated (diagnostic) values of HbA1c but with the clear exception of body mass index, and also C-reactive protein. The nonlinear associations of body mass index and C-reactive protein with fructosamine and glycated albumin have been shown in a number of previous studies 33–41 , but the mechanisms remain unexplained. It is possible that protein metabolism is altered in obese adults and may be affected by inflammation.…”

Section: Discussionmentioning

confidence: 93%

Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death

et al. 2015

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Background HbA1c is the standard measure to monitor glucose control in diabetes and is a marker of future cardiovascular risk. Fructosamine and glycated albumin are markers of short-term glycemic control but their associations with cardiovascular outcomes are uncharacterized. Methods and Results We measured glycated albumin and fructosamine in 11,104 participants with and without diabetes in the community-based Atherosclerosis Risk in Communities (ARIC) Study in 1990–1992 (baseline). We evaluated associations of fructosamine and glycated albumin with risk of coronary heart disease, ischemic stroke, heart failure and mortality. We compared associations to those observed for HbA1c. During two decades of follow-up there were 1096 new cases of coronary heart disease, 605 of ischemic stroke, 1432 of heart failure, and 2860 deaths. Elevated baseline concentrations of fructosamine and glycated albumin were significantly associated with each of the outcomes even after adjustment for traditional cardiovascular risk factors, with especially strong associations in persons with diabetes. Associations were of similar magnitude to those observed for HbA1c and—as has been previously observed for HbA1c—the associations tended to be J-shaped, with an elevation of risk at the lowest levels of each biomarker. Conclusions The acceptance of new measures of hyperglycemia is partly dependent on establishing their association with long-term outcomes. We found that fructosamine and glycated albumin were associated with vascular outcomes and mortality and that these associations were similar to those observed for HbA1c.

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Associations of glycated albumin and fructosamine with glycaemic status in urban black South Africans

Peer

George

Lombard

et al. 2021

Clinica Chimica Acta

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Determinants of fructosamine levels in a multi-ethnic Sub-Saharan African population

Cited by 5 publications

References 25 publications

Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death

Associations of glycated albumin and fructosamine with glycaemic status in urban black South Africans

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