Determinants of gastric emptying and transit in the small intestine

Malagelada, Juan–R.; Azpiroz, Fernando

doi:10.1002/cphy.cp060123

Cited by 40 publications

(49 citation statements)

References 200 publications

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“…Physiological stimuli in the gut elicit appropriate reflex responses to perform the digestive function (Malagelada et al, 1989). Normally, the digestive process evolves unperceived, but under some circumstances, patients may experience abdominal symptoms.…”

Section: Modulation Of the Autonomic Nervous System And Patients' Resmentioning

confidence: 99%

Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Manabe

Tanaka

Hata

et al. 2009

J. Smooth Muscle Res.

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Although irritable bowel syndrome (IBS) is the most common gastrointestinal disease and is found in up to 50% of patients referred to gastroenterologists, its pathogenesis remains unexplained. Lately most attention has been focused on visceral hypersensitivity related to dysfunction of the autonomic nervous system. Although there have been many reports regarding the autonomic nervous system in IBS patients, the results have not always been consistent. In many studies, increased sympathetic nervous system activity and decreased parasympathetic nervous system activity have been the most frequently noted differences when IBS patients are compared with healthy controls. There are also some differences among IBS symptom subgroups and some differences between men and women. Data from previous studies have been inconsistent, with complicating factors resulting in difficulties in classification and the possibility of multiple physiological pathways for a similar symptom picture. Further studies based on the Rome III criteria are required to evaluate whether or not autonomic functions significantly differ from each other. However, although there are many methods of measurement for evaluation of the autonomic nervous system, there are few of these methods that are not only accurate but also cost-effective, non-invasive, and easy to perform. Recently, we developed a new method with the abovementioned advantages for measuring fingertip blood flow in evaluating the autonomic nervous system by continuous-wave Doppler sonography. Using this method, we found that abnormal fingertip blood flow responses suggested the presence of excess sympathetic activity.

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Section: Modulation Of the Autonomic Nervous System And Patients' Resmentioning

confidence: 99%

Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Manabe

Tanaka

Hata

et al. 2009

J. Smooth Muscle Res.

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“…viscosity, osmolality, particle size and degree of hydrolysis by the enzyme), because of changes in their structures. It has been demonstrated that these factors affect the gastric emptying rate (Hunt & Stubbs, 1975;Malagelada & Azpiroz, 1989;Vist & Maughan, 1995).…”

Section: Introductionmentioning

confidence: 99%

Formation of a structured clot during the gastric digestion of milk: Impact on the rate of protein hydrolysis

et al. 2016

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“…Food is subsequently redistributed from the fundus to the corpus and antrum, and recurrent peristaltic waves mix the ingested foodstuffs [8]. The mixing process accomplishes trituration, or the very gentle breakdown of the chewed food into particles approximately 1 to 2 mm in diameter.…”

Section: Normal Gastric Neuromuscular Functionmentioning

confidence: 99%

Diagnosis and treatment of neuromuscular disorders of the stomach

Koch

2003

Curr Gastroenterol Rep

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Gastric neuromuscular disorders encompass a spectrum of dysfunction in nerve and smooth muscle that includes gastric visceral hypersensitivity, gastric dysrhythmias, fundic dysfunction, antral hypomotility, and gastroparesis. Patients with each disorder may present with such vague dyspepsia symptoms as early satiety, upper abdominal discomfort, bloating, or nausea with or without vomiting. A careful history and physical examination may suggest a gastric neuromuscular disorder, but symptoms are nonspecific. Gastroparesis is the most severe form of neuromuscular dysfunction. Such reversible causes of gastroparesis as mechanical obstruction of the stomach and chronic mesenteric ischemia must be excluded. Gastroparesis, gastric dysrhythmias, and hypersensitivity may follow viral infection or be due to degenerative processes that affect the gastric enteric neurons, smooth muscle, or interstitial cells of Cajal. Commonly, the cause of these gastric neuromuscular disorders is unknown. An approach to the diagnosis and treatment of gastric neuromuscular disorders is reviewed, including dietary counseling, drugs, and medical devices.

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Determinants of gastric emptying and transit in the small intestine

Cited by 40 publications

References 200 publications

Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Pathophysiology underlying irritable bowel syndrome -From the viewpoint of dysfunction of autonomic nervous system activity-

Formation of a structured clot during the gastric digestion of milk: Impact on the rate of protein hydrolysis

Diagnosis and treatment of neuromuscular disorders of the stomach

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