SummaryFood and nutritional (in)security remain an important matter of concern, especially in developing countries. Despite the efforts to enhance food security among smallholder soybean households, the proportion of the undernourished population in Butere Sub-County still remains high for unknown reasons. Therefore, the purpose of this paper is to examine the determinants of food security among smallholder soybean households in Butere Sub-County, Kenya. The study adopted the exploratory research design. A multi-stage sampling procedure was used to select a sample of 201 respondents. Cross-sectional data were gathered through face-to-face interviews using pretested semi-structured questionnaires and analyzed using ordered logistic regression model. Household Food Insecurity Access Scale was used to measure and categorize the soybean household food (in)security status. The results revealed that the household food (in)security status differed across soybean households and was greatly influenced by an interplay of socio-economic, market, and institutional factors. Age of the household head negatively influenced food security, whereas the level of soybean commercialization, education, livestock units, network density, extension visits, and credit access were positively associated with household food security. The study recommends policy interventions that seek to ensure intensive literacy development, frequent extension and training, improved access to credit, and reinvestment in productive assets or inputs for increased production, commercialization and food security. Strengthening of social ties and increased allocation to safety net programs for the aged, vulnerable, and resource-poor households are also recommended.