Determinants of Genital Human Papillomavirus Infection in Low-Income Women in Washington, D.C

Hildesheim, Allan; Gravitt, Patti E.; Schiffman, Mark; Kurman, Robert J.; Barnes, Willard A.; Jones, S; Tchabo, Jean-Gilles; Brinton, Louise A.; Copeland, Christopher; Epp, Joanne

doi:10.1097/00007435-199309000-00008

Cited by 148 publications

(69 citation statements)

References 13 publications

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“…Despite this limitation the pre valence of HPV observed in the c u r rent study, in both cases and contro l s, is consistent with previous studies using PCR methods (Mu ñ oz, 1997). Si m i l a r l y, the ra c i a l / ethnic differences in the pre valence of HPV infection in the control group is consistent with the data re p o rted by Hildesheim et al (1993). These authors also found a higher pre va l e n c e of HPV infection among African Ameri c a n s (43.9%), intermediate in whites (32.1%), and l ower in Hispanics (25.5%) among a clinicbased population of women with normal cytologic smear residing in the Washington, DC a rea (Hildesheim et al, 1993).…”

Section: Discussionsupporting

confidence: 89%

A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: Differences among racial/ethnic groups

Tortolero‐Luna¹

2005

Gynecologic Oncology

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We conducted a case-control study of the association between SIL and HPV among whites (W ) , African Americans (AA), and Hispanics (H) in Harris County, Tex a s . Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. C o n t rols were identified among W and AA, ), re s p e c t i ve l y.Si m i l a rl y, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7 . 7 , and 4.3, re s p e ct i vely) and HSIL (AOR = 78.6, 3 4 . 6 , and 14.2 AO R : 29,5 (12,5); 15,3 (6,8); e 5,8 (2,[6][7][8][9][10][11][12]6). De forma similar, f o ram observadas diferenças para ambos LSIL (AO R , re s p e c t i va m e n t e , de 16,6; 7,7 e 4,3) e HSIL (AOR de 78,6; 34,6 e 142). Os resultados apóiam a existência de associação entre SIL e H P V, d i f e renças na força de associação com SILs e HSILs, e sugerem risco mais elevado para mul h e res latinas e menor para mulheres negra s . , re s p e c t i ve l y ) . Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Da t a also suggest a higher risk for H and a lower risk for AA. Key words Pa p i l l o m a v i r u s ; Ce rvix Ne o p l a s m s ; Ethnic Gro u p s ; Ca s e -C o n t rol St u d i e s Resumo Foi realizado um estudo caso-controle para analisar a associação entre lesões intraepiteliais escamosas do colo uterino (SIL) e HPV entre mulheres bra n c a s , n e g ras e latinas em Harris County, Tex a s . Os casos foram identificados na M. D. Anderson Cancer Center Colposcopy C l i n i c , e os controles foram obtidos realizando-se exame de Papanicolau em duas clínicas do De p a rtamento de Saúde. O HPV foi detectado por meio de ensaio de PCR (primer MY09/MY11). Fo ram construídos modelos de re g ressão logística para estimar as odds ra t i o s ajustadas (AO R ) , e seus intervalos de confiança de 95% (IC) de SIL entre os grupos étnicos e graus da doença. A prevalência de HPV nas SIL de baixo grau (LSIL) foi de 64%; nas de alto grau (HSIL), 8 4 % ; e 19% nos c o n t ro l e s . O risco de SIL foi maior em mulheres latinas que em brancas e negra s , sendo observad a s , re s p e c t i va m e n t e , as seguintes Palavras-chave Pap il om av ir u s ; Neoplasias do Colo Ut e r i n o ; Grupos Étnicos; Estudos de Casos e C o n t ro l e s

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Section: Discussionsupporting

confidence: 89%

A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: Differences among racial/ethnic groups

Tortolero‐Luna¹

2005

Gynecologic Oncology

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“…In women, HPV infection declines with increasing age, with a smaller postmenopausal peak observed in some populations [37][38][39][40]. In contrast, we did not identify a linear association between age and HPV infection in our study.…”

Section: Discussioncontrasting

confidence: 88%

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

et al. 2003

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Human papillomavirus (HPV) is the main etiologic agent of anogenital cancers, including cervical cancer, but little is known about the type-specific prevalence of HPV in men. Participants were men aged 18-70 years attending a sexually transmitted disease clinic. Penile skin swabs were assessed for HPV DNA using polymerase chain reaction with reverse line-blot genotyping. Of 436 swabs collected, 90.1% yielded sufficient DNA for HPV analysis. Men with inadequate swab samples were significantly more likely to be white and circumcised than men with adequate swab samples. The prevalence of HPV was 28.2%. Oncogenic HPV types were found in 12.0% of participants, nononcogenic types were found in 14.8% of participants, multiple types were found in 6.1% of participants, and unknown types were found in 5.9% of participants. The most prevalent subtypes were nononcogenic 6, 53, and 84. HPV positivity was not associated with age. These results indicate that HPV infection among men at high risk is common but that characteristics of male HPV infection may differ from those of female infection.Human papillomavirus (HPV) infection is the necessary, sexually transmitted cause of invasive cervical cancer and its precursor lesion, cervical intraepithelial neoplasia [1][2][3]. HPV has also been closely linked with other anogenital cancers, including anal cancer and certain penile cancers [4][5][6]. HPV infection in men is over- whelmingly subclinical, which has resulted in a potentially large number of asymptomatic carriers who serve as reservoirs and vectors for the virus.Although HPV has been studied extensively in women, data on male infection are limited. Studies of HPV in men are necessary to improve our understanding of HPV transmission and HPV-related carcinogenesis and to prevent disease in both men and women. The success of future cancer prevention strategies, such as prophylactic HPV vaccination, will be limited without a basic epidemiological understanding of HPV in men.Earlier studies of papillomavirus infection in men used a variety of clinical and histological techniques to establish a diagnosis of HPV, but polymerase chain reaction (PCR) has emerged as the most sensitive method available for the detection of latent HPV [7][8][9]. Among studies that have used PCR to detect penile HPV DNA in healthy men, sampling methodologies have been inconsistent. Nonetheless, results from these diverse investigations have suggested that penile HPV in sexually active men is at least as prevalent as cervical HPV is among women [10][11][12][13][14][15].HPV prevalence in men has been shown to vary by

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“…An association between HPV DNA and oral contraceptive use, after adjustment for sexual habits, was reported in some studies [7,10,26,28,29], but not in others [8,27,30,31], and whether oral contraceptives affect the incidence or prevalence of HPV infection remains unclear [32].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus infection in women in Turin, Italy

Ronco

Ghisetti

Segnan

et al. 2005

European Journal of Cancer

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Human papillomavirus (HPV) is recognised as necessary for the development of cervical cancer. An age-stratified random sample of 1013 women, aged 25-70 years, participating in the organised cervical screening programme in Turin, Italy was tested for 36 HPV types using polymerase chain reaction (PCR) with the general primers GP5+/GP6+. The overall HPV prevalence was 8.8%. Highrisk types were found in 7.1% of women and multiple infections in 1.1%. HPV-16 was the most common type (32.6% of HPVpositive women). HPV prevalence (any type) was 13-14% at ages 25-39 years, 11.5% at age 40-44 years, and approximately 5% among older women. After age-adjustment, HPV prevalence was significantly increased in single vs married, (Odds Ratio (OR) = 2.23; 95% Confidence Interval (CI): 1.28-3.89) and decreased in parous vs nulliparous women (OR = 0.49; 95% CI: 0.31-0.78). However, the association with marital status and parity was restricted to women less than 45 years of age. In conclusion, overall, the female population of Turin showed an HPV prevalence that is intermediate compared with worldwide levels.

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Determinants of Genital Human Papillomavirus Infection in Low-Income Women in Washington, D.C

Cited by 148 publications

References 13 publications

A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: Differences among racial/ethnic groups

A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: Differences among racial/ethnic groups

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

Prevalence of human papillomavirus infection in women in Turin, Italy

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