Determinants of GH resistance in malnutrition

Fazeli, Pouneh K.; Klibanski, Anne

doi:10.1530/joe-13-0477

Cited by 128 publications

(93 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors found a decrease in weight and height standards associated with growth hormone resistance, which improved after shunt surgery. However, they compared the growth-related hormone profiles of malnourished children and healthy children, which could reflect bias since nutritional status may have influenced the studied hormone profiles [8,19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of growth and nutritional status in children and adolescents with extrahepatic portal vein obstruction and portal hypertension

et al. 2017

View full text Add to dashboard Cite

Objective: This study aims to evaluate dietary intake, nutritional status, and growth rate in children and adolescents with extrahepatic portal vein obstruction and portal hypertension. Methods: Outpatients aged 1-18 years, diagnosed with extrahepatic portal vein obstruction and portal hypertension, who had no associated diseases, and who had not been subjected to a venous shunt were included in this study. Two evaluations were carried out in this study: an initial (evaluation 1) and a final evaluation (evaluation 2), with a three-month minimum interval between them. In each evaluation, dietary intake was analyzed comparing the results with recommended energy intake using the Harris & Benedict equation and participants’ anthropometric data, such as weight, height, mid-arm muscle circumference, weight-for-age, height-for-age, and body mass index-for-age, based on the World Health Organization 2006 standards. Results: A total of 22 patients participated in this study. There was a significant improvement in weight, height, body mass index, and mid-arm muscle circumference measurements (p<0.001; p<0.001; p<0.017; p=0.0018 respectively) and in the relationship between dietary intake and energy recommended energy intake, according to the Harris & Benedict equation (p=0.0001) from the first and second evaluation. Conclusion: Extrahepatic portal vein obstruction and portal hypertension were not shown to be factors predisposing to malnourishment.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of growth and nutritional status in children and adolescents with extrahepatic portal vein obstruction and portal hypertension

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Chronic undernutrition and protein deficiency result in GH resistance and suppression of IGF-1, in turn leading to stunting [20]. GH induces IGF-1 production in the liver and local tissues and, together with IGF-1-binding protein-3, regulates somatic growth [19].…”

Section: Biomarkers Of Eed Inflammation and Growth Hormone Resistancementioning

confidence: 99%

“…Detection of substantial increases in IGF-1 during therapeutic interventions may be an early indicator for reversal of linear growth faltering. In addition, during periods of protein and caloric deprivation, rising levels of endocrine hormone fibroblast growth factor 21 (FGF21) and protein deacetylase Sirtuin 1 appear to drive GH resistance [20]. Prolonged exposure to high levels of circulating FGF21 disrupts GH signaling and inhibits growth at the bone plate [34-37].…”

Section: Biomarkers Of Eed Inflammation and Growth Hormone Resistancementioning

confidence: 99%

“…Growing evidence supports the influence of the intestinal microbiome on the physiology of childhood growth and development. Early alterations in gut microbiota diversity, composition, and function via environmental exposures, breast milk composition, and enteric infections can adversely affect growth through nutrient malabsorption, altered metabolism, gut inflammation, and dysregulation of the somatotropic hormone axis [11, 19, 20]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomarkers to Stratify Risk Groups among Children with Malnutrition in Resource-Limited Settings and to Monitor Response to Intervention

2017

View full text Add to dashboard Cite

Despite global efforts to reduce childhood undernutrition, current interventions have had little impact on stunting and wasting, and the mechanisms underlying growth faltering are poorly understood. There is a clear need to distinguish populations of children most likely to benefit from any given intervention and to develop tools to monitor response to therapy prior to the development of morbid sequelae. In resource-limited settings, environmental enteric dysfunction (EED) is common among children, contributing to malnutrition and increasing childhood morbidity and mortality risk. In addition to EED, early alterations in the gut microbiota can adversely affect growth through nutrient malabsorption, altered metabolism, gut inflammation, and dysregulation of the growth hormone axis. We examined the evidence linking EED and the gut microbiome to growth faltering and explored novel biomarkers to identify subgroups of children at risk of malnutrition due to underlying pathology. These and other biomarkers could be used to identify specific groups of children at risk of malnutrition and monitor response to targeted interventions.

show abstract

“…This state is an acquired GH resistance and an adaptive response to decreased energy intake (4,5). Therefore low IGF-1 levels lead to minimal anabolic effects thus energy can be used for acute needs and slowdown the catabolic process consequently to form aprotective mechanism for survival (6).…”

Section: Introductionmentioning

confidence: 99%

Boy kısalığı, yetersiz boy uzaması ve kemik yaşı geriliği birlikteliği: Nutrisyonel boy kısalığı mı büyüme hormonu eksikliği mi?

Sezer¹,

Buluş²

2016

J Contemp Med

View full text Add to dashboard Cite

Amaç: Serum insülin benzeri growth faktörü 1 (IGF-1) düzeyleri beslenme ve serum büyüme hormonu düzeyleriyle etkileşir, bu nedenle IGF-1 büyüme ve beslenmeyi gösteren bir parametre olabilir. Bu çalışmada, yetersiz boy uzaması ve kemik gelişimi olan çocuklarda nutrisyonel büyüme geriliğinin (NBG) büyüme hormon eksikliğinden (BHE) ayırımda kullanılabilecek serum IGF-1 kesim seviyeleri araştırıldı.Gereç ve Yöntem: Çalışmaya malnutrisyon sonucu NBG saptanan 57 çocuk ve BHE'ye bağlı boy kısalığı olan benzer yaş ve cinsiyette 36 çocuk alındı. Tüm çocuklarda serum IGF-1 seviyesi immunometrik chemiluminescent yöntemiyle ölçüldü.Bulgular: NBG ve GHD grupları arasında serum IGF-1 seviyeleri açısından anlamlı fark saptanmadı (p> 0.05). NBG'li çocukları GHD'li çocuklardan ayırmak için istatistiksel olarak anlamlı IGF-1 kesim seviyesi saptanmadı.Sonuç: NBG'li çocukları BHE olan çocuklardan ayırmak için serum IGF-1 seviyesi incelemenin gereksiz bir yöntem olduğunu düşünüyoruz.Background/Aim: Serum insulin-like growth factor 1 (IGF-1) concentrations are affected both by nutritional status and serum growth hormone levels therefore IGF-1 is useful as an indicator of growth and nutritional status. The aim of this study is to determine the cut off level of IGF-1 to differentiate nutritional growth retardation (NGR) from growth hormone deficiency (GHD) in children with insufficient annual height growth and back bone age.Methods: The study group included 57 children who had been diagnosed with NGR due to malnutrition and 36 children with similar age and sex, who had been diagnosed with short stature due to GHD. Serum IGF-1 concentrations were determined by chemiluminescent immunometric assay in all children.Results: There was no significant difference in serum IGF-1 levels between NGR and GHD groups. We could not find an IGF-1 cut off level to differentiate NGR from GHD in children with NGR. Conclusion:We suggest that examination of IGF-1 levels in children with NGR to exclude GHD is not useful.

show abstract

Determinants of GH resistance in malnutrition

Cited by 128 publications

References 76 publications

Evaluation of growth and nutritional status in children and adolescents with extrahepatic portal vein obstruction and portal hypertension

Evaluation of growth and nutritional status in children and adolescents with extrahepatic portal vein obstruction and portal hypertension

Biomarkers to Stratify Risk Groups among Children with Malnutrition in Resource-Limited Settings and to Monitor Response to Intervention

Boy kısalığı, yetersiz boy uzaması ve kemik yaşı geriliği birlikteliği: Nutrisyonel boy kısalığı mı büyüme hormonu eksikliği mi?

Contact Info

Product

Resources

About