Determinants of glycemic control: Phase 2 analysis from nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2018)

Esteghamati, Alireza; Ismail‐Beigi, Faramarz; Khaloo, Pegah; Moosaie, Fatemeh; Alemi, Hamid; Mansournia, Mohammad Alì; Afarideh, Mohsen; Molla, Ghasem Janbabaei; Ghadimi, Teyyeb; Shadnoush, Mahdi; Kermanchi, Jamshid; Ghaemi, Fatemeh

doi:10.1016/j.pcd.2019.07.002

Cited by 18 publications

(20 citation statements)

References 44 publications

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“…Some authors have described the presence of HTN as a predictor of poor glycemic control [17,33]. However, we did not nd a signi cant association between HTN and PGC.…”

Section: Discussioncontrasting

confidence: 96%

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The Effect of Comorbidities on Glycemic Control Among Colombian Adults With Diabetes Mellitus: a Longitudinal Approach With Real-world Data

Urina-Jassir¹,

Herrera-Parra²,

Vargas³

et al. 2021

Preprint

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Background: Achieving an optimal glycemic control has been described to reduce the incidence of diabetes mellitus (DM) related complications. The association between comorbidities and glycemic control remains unclear. Our aim is to evaluate the effect of comorbidities on glycemic control in people with DM.Methods: A retrospective longitudinal study on data from the National Registry of Chronic Kidney Disease from 2014 to 2019 in Colombia. The outcome was poor glycemic control (PGC = HbA1c ≥7.0%). The association between each comorbidity (hypertension (HTN), chronic kidney disease (CKD) or obesity) and PGC was evaluated through multivariate mixed effects logistic regression models. The measures of effect were odds ratios (OR) and their 95% confidence intervals (CI). We also evaluated statistical interaction between each comorbidity and ethnicity. Results: From 969,531 people at baseline, 85% had at least one comorbidity; they were older and mostly female. In people with DM and CKD, the odds of having a PGC were 78% (OR: 1.78, CI 95%: 1.55-2.05) higher than those without CKD. Same pattern was observed in obese for whom the odds were 52% (OR: 1.52, CI 95%: 1.31-1.75) higher than in non-obese. Non-significant association was found between HTN and PGC. The association of interest was statistically modified by ethnicity (afro descendant). Conclusions: Prevalence of comorbidities was high in adults with DM. Patients with concomitant CKD or obesity had significantly higher odds of having a PGC.

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“…Some authors have described the presence of HTN as a predictor of poor glycemic control [17,33]. However, we did not nd a signi cant association between HTN and PGC.…”

Section: Discussioncontrasting

confidence: 96%

“…Together, these results indicate that an elevated BMI increases the risk of PGC in patients with DM. Similar conclusions have been described in previous studies [29,33]. A cross sectional study in Iranian population with diabetes found an association between obesity and poor glycemic control [33].…”

Section: Discussionsupporting

confidence: 89%

The Effect of Comorbidities on Glycemic Control Among Colombian Adults With Diabetes Mellitus: a Longitudinal Approach With Real-world Data

Urina-Jassir¹,

Herrera-Parra²,

Vargas³

et al. 2021

Preprint

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show abstract

“…Together, these results indicate that an elevated BMI increases the risk of PGC in patients living with DM. Similar conclusions have been described in previous studies [ 37 , 41 ]. A cross sectional study in Iranian population living with diabetes found an association between obesity and poor glycemic control [ 41 ].…”

Section: Discussionsupporting

confidence: 93%

“…Similar conclusions have been described in previous studies [ 37 , 41 ]. A cross sectional study in Iranian population living with diabetes found an association between obesity and poor glycemic control [ 41 ]. Furthermore, Bae et al describe an increased probability of suboptimal glycemic control when overweight or obesity was present in patients living with DM in the USA [ 37 ].…”

Section: Discussionsupporting

confidence: 93%

The effect of comorbidities on glycemic control among Colombian adults with diabetes mellitus: a longitudinal approach with real-world data

Urina-Jassir¹,

Herrera-Parra²,

Vargas³

et al. 2021

BMC Endocr Disord

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Background Achieving an optimal glycemic control has been described to reduce the incidence of diabetes mellitus (DM) related complications. The association between comorbidities and glycemic control remains unclear. Our aim is to evaluate the effect of comorbidities on glycemic control in people living with DM. Methods A retrospective longitudinal study on data from the National Registry of Chronic Kidney Disease from 2014 to 2019 in Colombia. The outcome was poor glycemic control (PGC = HbA1c ≥7.0%). The association between each comorbidity (hypertension (HTN), chronic kidney disease (CKD) or obesity) and PGC was evaluated through multivariate mixed effects logistic regression models. The measures of effect were odds ratios (OR) and their 95% confidence intervals (CI). We also evaluated the main associations stratified by gender, insurance, and early onset diabetes as well as statistical interaction between each comorbidity and ethnicity. Results From 969,531 people at baseline, 85% had at least one comorbidity; they were older and mostly female. In people living with DM and CKD, the odds of having a PGC were 78% (OR: 1.78, CI 95%: 1.55-2.05) higher than those without CKD. Same pattern was observed in obese for whom the odds were 52% (OR: 1.52, CI 95%: 1.31-1.75) higher than in non-obese. Non-significant association was found between HTN and PGC. We found statistical interaction between comorbidities and ethnicity (afro descendant) as well as effect modification by health insurance and early onset DM. Conclusions Prevalence of comorbidities was high in adults living with DM. Patients with concomitant CKD or obesity had significantly higher odds of having a PGC.

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“…Ten mL of blood sample was drawn from each participants at 12–14h after an overnight fast. The samples were centrifuged (1500 rmp, for 10 min at standard room temperature 21 °C)[14] and stored in the temperature of −70 °C for laboratory evaluation. Serum concentrations of Lp(a), apoB, and apoA1 were measured using immunoturbidimetry (Beckman Coulter Inc., FL).…”

Section: Methodsmentioning

confidence: 99%

LDL/Apo B ratio and Lp (a) Each Predict Coronary Artery Disease in Type2 Diabetes Independent of ASCVD Risk Score: A Case-Cohort Study

Rabizadeh

Rajab

Mechanick

et al. 2020

Preprint

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Aim: To evaluate the predictive value of the LDL/ApoB ratio for coronary heart disease (CHD) in patients with type2 diabetes (T2D). Methods: In this case-cohort study, (apo)lipoproteins and glycemic indices were measured in 1058 individuals with T2D from February 2002 to March 2019, with a median duration of follow up of 10 years. Results: Of 1058 patients with T2D, coronary heart disease occurred in 242 patients. Increased waist circumference, waist to hip ratio, and hemoglobin A1c, low-density lipoprotein cholesterol (LDL)/Apolipoprotein B (ApoB) ratio, presence of hypertension and metabolic syndrome, and insulin and statin use were more prevalent among patients with CHD (P<0.001). Logistic regression analysis showed that an LDL/ApoB ratio equal or lower than 1.2, as well as a Lp(a) cutoff level more than 25.45 mg/dl could each predict CHD independent of ASCVD risk score [adjusted OR:1.841, CI:1.257 to 2.698, P<0.001 and adjusted OR: 1.433, CI:1.014 to 2.026, P=0.041) respectively ] when adjusted for multiple confounders.The atherogenic index of plasma (AIP) did not predict CHD. Conclusion: This study showed that LDL/ApoB ratio and Lp(a) each, but not the atherogenic index of plasma, may be considered as an indicator of CHD independent of ASCVD risk score in patients with T2D. This finding merits further clarification to optimize preventive strategies for CHD.

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Determinants of glycemic control: Phase 2 analysis from nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2018)

Cited by 18 publications

References 44 publications

The Effect of Comorbidities on Glycemic Control Among Colombian Adults With Diabetes Mellitus: a Longitudinal Approach With Real-world Data

The Effect of Comorbidities on Glycemic Control Among Colombian Adults With Diabetes Mellitus: a Longitudinal Approach With Real-world Data

The effect of comorbidities on glycemic control among Colombian adults with diabetes mellitus: a longitudinal approach with real-world data

LDL/Apo B ratio and Lp (a) Each Predict Coronary Artery Disease in Type2 Diabetes Independent of ASCVD Risk Score: A Case-Cohort Study

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