Determinants of hyperleptinaemia in an African population

Njelekela, Marina; Kuga, Sachiko; Hiraoka, Junko; Masesa, Zablon; Ntogwisangu, Josiah; Mashalla, Yohana; Ikeda, Katsumi; Mtabaji, Jacob; Nara, Yasuo; Yamori, Yukio; Tsuda, Kinsuke

doi:10.4314/eamj.v80i4.8641

Cited by 2 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in accordance with a previous report [25]. In some studies, [15] and especially in children [26], independent predictive factor of the serum lipids on the serum leptin have been reported. The findings in our study are to some extent unexpected.…”

Section: Discussionsupporting

confidence: 93%

Leptin in the General Population, Differences in Sex Hormones, Blood Lipids, Gender and Life Style Characteristics

Olstad¹

2011

TOBSJ

View full text Add to dashboard Cite

Introduction: Fat mass is the main predictor of the serum concentration of leptin, a 167-amino acid peptide hormone encoded by the obesity gene. There is no general agreement about other determinant factors of serum leptin, but attention has been focused on gender and sex hormones. The objective of this study was to describe gender differences in a population study and evaluate the individual contribution of life style characteristics, blood lipid pattern and sex hormones as determinants of serum leptin. Materials and Methodology: In a multipurpose, cross-sectional general health survey, ("Tromsø IV"-N = 27.159), conducted during the years 1994/95, measurement of leptin was performed in a sub sample of 1812 subjects. Multiple regression analysis was performed in order to establish the importance of each predictor. Results: Gender differences in leptin increased with increasing BMI, and the gender predicted 33 % of the variation of leptin. Differences in life style factors between men and women could not explain gender differences. Smoking, physical activity, testosterone and SHBG were independent negative predictive factors. Estradiol was positive predictive factor of serum leptin. However, all contributed to a small variation in serum leptin. A gender dimorphism was observed between serum leptin and serum testosterone and between serum testosterone and BMI. Conclusions: BMI and gender were strong predictors in variations in serum leptin. Life style factors and sex hormones were less predictive. Gender dimorphisms between leptin, testosterone and BMI indicate a complex relationship between body fat distribution and the two hormones.

show abstract

Section: Discussionsupporting

confidence: 93%

Leptin in the General Population, Differences in Sex Hormones, Blood Lipids, Gender and Life Style Characteristics

Olstad¹

2011

TOBSJ

View full text Add to dashboard Cite

show abstract

“…[38][39][40] However, studies on leptin are limited in African populations 41,42 and the effects of leptin on cardiovascular function in Africans are absent (Table 5). Lean NT, lean normotensive; OW/OB NT, overweight/obese normotensive; OW/OB HT, overweight/obese hypertensive; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; SV, stroke volume; CO, cardiac output; TPR, total peripheral resistance; C W , Windkessel arterial compliance; PP, pulse pressure; Leptin, fasting leptin; Insulin, fasting insulin; Glucose, fasting glucose; HOMA-IR, homeostatic model assessment insulin resistance index; TC, total cholesterol; HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; Trig, triglycerides; BMI, body mass index; Waist circum., waist circumference; fat %, fat percentage.…”

Section: Discussionmentioning

confidence: 99%

Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study

et al. 2005

View full text Add to dashboard Cite

High leptin levels are often observed in human obesity and are implicated in obesity-related hypertension. Leptin levels have been found to be higher in hypertensive obese African-American women compared to normotensive African-American women, but a direct association between leptin and blood pressure could not be obtained. Additionally, increased adiposity has been associated with higher aortic stiffness in obese African-American women, but leptin was not included in the study. The effects of leptin on cardiovascular function in African women have not yet been determined. We hypothesised that leptin is directly associated with blood pressure and decreased arterial compliance and that leptin levels are significantly higher in hypertensive overweight/obese African women compared to normotensive overweight/obese African women. A case-case control study was performed which included 98 African women. The subjects were divided into lean normotensive (lean NT), overweight/obese normotensive (OW/OB NT) and overweight/obese hypertensive (OW/OB HT). The Finometer apparatus was used to obtain a more elaborate cardiovascular profile. Serum leptin and insulin levels as well as the HOMA-IR index were determined. Various anthropometric measures were obtained. Leptin levels were elevated (Pp0.05) in the OW/OB NT and HT groups compared to the lean NT group, but were similar in the OW/OB NT and HT groups. After adjusting for obesity, insulin resistance, hyperinsulinaemia and age, a direct positive correlation was obtained between leptin and systolic blood pressure (SBP) (Pp0.05; r ¼ 0.68) in the OW/OB HT group. Additionally, leptin also correlated negatively with arterial compliance (Pp0.05; r ¼ À0.76) and positively with pulse pressure (Pp0.05; r ¼ 0.71) in the OW/OB HT group. In conclusion, even though leptin levels were the same in OW/OB HT and NT African women, leptin was directly and positively associated with SBP and pulse pressure and negatively with C W only in OW/OB HT African women, independent of obesity, insulin-resistance, hyperinsulinaemia and age.

show abstract

Determinants of hyperleptinaemia in an African population

Cited by 2 publications

References 20 publications

Leptin in the General Population, Differences in Sex Hormones, Blood Lipids, Gender and Life Style Characteristics

Leptin in the General Population, Differences in Sex Hormones, Blood Lipids, Gender and Life Style Characteristics

Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study

Contact Info

Product

Resources

About