Determinants of low bone mineral density in people with multiple sclerosis: Role of physical activity

Cleland, Brice T.; Papanek, Paula E.; Ingraham, Benjamin; Harkins, April L.; Garnier‐Villarreal, Mauricio; Woo, Douglas; Csuka, Mary Ellen; Ng, Alexander V.

doi:10.1016/j.msard.2019.101864

Cited by 10 publications

(6 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inconsistent findings in literature have linked BMD and the risk of fracture with the risk of MS (Bisson et al, 2019; Olsson et al, 2018). Different factors can contribute to reduced BMD and bone metabolism in patients with MS, including reduced physical activity and depression (Cleland et al, 2020), thus increasing the risk of fracture and osteoporosis in these patients (Bisson et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

A systematic review of Mendelian randomization studies on multiple sclerosis

Fazia

Baldrighi

Nova

et al. 2023

Eur J of Neuroscience

View full text Add to dashboard Cite

Mendelian randomization (MR) is a powerful approach for assessing the causal effect of putative risk factors on an outcome, using genetic variants as instrumental variables. The methodology and application developed in the framework of MR have been dramatically improved, taking advantage of the many public genome‐wide association study (GWAS) data. The availability of summary‐level data allowed to perform numerous MR studies especially for complex diseases, pinpointing modifiable exposures causally related to increased or decreased disease risk. Multiple sclerosis (MS) is a complex multifactorial disease whose aetiology involves both genetic and non‐genetic risk factors and their interplay. Previous observational studies have revealed associations between candidate modifiable exposures and MS risk; although being prone to confounding, and reverse causation, these studies were unable to draw causal conclusions. MR analysis addresses the limitations of observational studies and allows to establish reliable and accurate causal conclusions. Here, we systematically reviewed the studies evaluating the causal effect, through MR, of genetic and non‐genetic exposures on MS risk. Among 107 papers found, only 42 were eligible for final evaluation and qualitative synthesis. We found that, above all, low vitamin D levels and high adult body mass index (BMI) appear to be uncontested risk factors for increased MS risk.

show abstract

Section: Resultsmentioning

confidence: 99%

A systematic review of Mendelian randomization studies on multiple sclerosis

Fazia

Baldrighi

Nova

et al. 2023

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Bone metabolism in patients with MS is very complex ( 39 ). Different kinds of factors, such as physical activity, depression, and fatigue contributed to reduced femoral neck BMD in patients with MS independently ( 39 ). The supplementation with propionic acid may protect against osteoporosis in patients with MS ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

Gao

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a neurodegenerative disorder and an autoimmune disease. Until now, observational studies have indicated the association of bone mineral density (BMD) and fracture with the risk of MS. However, these studies indicated inconsistent findings. Until now, genome-wide association studies (GWAS) have been conducted in BMD, fracture, and MS, which provide large-scale datasets to investigate the causal association of BMD and fracture with the risk of MS using the Mendelian randomization (MR) study. Here, we performed an MR study to clarify the causal association between BMD/fracture and the risk of MS using large-scale publicly available GWAS datasets from BMD, fracture, and MS. We first evaluated the bidirectional causal effects of BMD and MS. The main analysis method inverse-variance weighted (IVW) showed no significant causal effect of BMD on the risk of MS (β = 0.058, and p = 1.98E-01), and MS on the risk of BMD (β = −0.001, and p = 7.83E-01). We then evaluated the bidirectional causal effects of fracture and MS. However, we only identified a significant causal effect of fracture on the risk of MS using IVW (β = −0.375, p = 0.002), but no significant causal effect of MS on the risk of the fracture using IVW (β = 0.011, p = 2.39E-01). Therefore, our main analysis method IVW only found a significant causal effect of fracture on MS using the threshold for the statistically significant association p < 0.05/4 = 0.0125. Meanwhile, multivariable MR analyses showed that the causal effect of fracture on MS was independent of smoking, drinking, and obesity, but dependent on BMD. In summary, our MR analysis demonstrates that genetically increased fracture may reduce the risk of MS. Our findings should be further verified and the underlying mechanisms should be further evaluated by future studies.

show abstract

“…The results of the study showed that addressing depression (as well as symptomatic fatigue) and increasing physical activity can improve bone mineral density in multiple sclerosis patients. However, OPN concentrations did not differ significantly, as the OPN level (ng/mL) in the study group was 57.0 (15.9), while in the control group, it was 56.3 (12.5) [44]. Proteomic analysis of urine in a mouse model of major depressive disorder (MDD) under chronic unpredictable mild stress (CUMS) showed a decrease in OPN levels in the study group [45].…”

Section: Opn In Psychiatrymentioning

confidence: 99%

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

Golub

Ordak

Nasierowski

et al. 2023

IJMS

View full text Add to dashboard Cite

One of the factors that increase the effectiveness of the pharmacotherapy used in patients abusing various types of new psychoactive substances (NPSs) is the proper functioning of the liver. However, the articles published to date on NPS hepatotoxicity only address non-specific hepatic parameters. The aim of this manuscript was to review three advanced markers of hepatotoxicity in psychiatry, namely, osteopontin (OPN), high-mobility group box 1 protein (HMGB1) and glutathione dehydrogenase (GDH, GLDH), and, on this basis, to identify recommendations that should be included in future studies in patients abusing NPSs. This will make it possible to determine whether NPSs do indeed have a hepatotoxic effect or whether other factors, such as additional substances taken or hepatitis C virus (HCV) infection, are responsible. NPS abusers are at particular risk of HCV infection, and for this reason, it is all the more important to determine what factors actually show a hepatotoxic effect in them.

show abstract

Determinants of low bone mineral density in people with multiple sclerosis: Role of physical activity

Cited by 10 publications

References 58 publications

A systematic review of Mendelian randomization studies on multiple sclerosis

A systematic review of Mendelian randomization studies on multiple sclerosis

Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis

Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances

Contact Info

Product

Resources

About