Determinants of Mortality among Cervical Cancer Patients Attending in Tikur Anbessa Specialized Hospital, Ethiopia: Institutional-Based Retrospective Study

Wassie, Mulugeta; Fentie, Beletech; Asefa, Tseganesh

doi:10.1155/2021/9916050

Cited by 6 publications

(9 citation statements)

References 36 publications

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“…The mortality rate in this study is substantial, but very strongly correlated with the recent estimate of 31 per 100-women years in Ethiopia ( 9 ). However, it also varies widely from estimates in other previous studies with the rates ranging from 15.6 to as high as 79.8 per 100 women-years ( 10 , 11 ). This may be due to the selection of the study population as mortality from hospital-based data are usually higher than that of the population.…”

Section: Discussionmentioning

confidence: 63%

“…Our study shows that anemia significantly reduces disease-specific survival by more than 80%. A possible mechanism responsible for this is anemia-induced hypoxia which is associated with decreased tumor susceptibility to anticancer medications and increased morbidity in general ( 10 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

“…Information about age, location/residence, occupation, religion, ethnicity, educational level, and marital status were extracted from the biodata section of the records. Age at diagnosis was categorized broadly as age 50 years or younger and age older than 50 years based on previous research ( 10 ). Data on occupation was classified as either unemployed or based on skill levels derived using the latest versions of the International Labor Organization’s International Standard Classification of Occupations 2008 [ISCO-08 and ISCO-88] ( 28 ).…”

Section: Methodsmentioning

confidence: 99%

“…Variables such as family history of cervical cancer, cigarette smoking, educational level, alcohol, and other substances use, HIV/AIDS status, anemia, stage of the disease, and types of treatment received with a p-value less than 0.25 ( 30 ) were considered relevant and were included in the multivariable Cox regression model. In the multivariable analysis, the p-value of anemia was statistically insignificant (p-value = 0.856), however, we retained anemia in the model because the overall p-value for the model was <0.001 and previous research showed that anemia was relevant in the model ( 9 , 10 ).…”

Section: Methodsmentioning

confidence: 99%

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Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria

et al. 2023

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IntroductionCervical cancer (CCa) is the fourth most frequent and a common cause of cancer mortality in women, the majority of whom live in low- and middle-income countries. Data on CCa mortality and its determinants have been poorly studied in Nigeria, resulting in a paucity of information that can assist patient management and cancer control policy.AimThe purpose of this study was to assess the mortality rate among CCa patients in Nigeria as well as the major factors influencing CCa mortality.Study designData from the medical records of 343 CCa patients seen at the Lagos University Teaching Hospital and NSIA-LUTH Cancer Center from 2015 to 2021 were used in a retrospective cohort analysis. The hazard ratios (HR) and confidence intervals (CI) associated with the exposure variables and CCa mortality were calculated using Cox proportional hazard regression.ResultsThe CCa mortality rate was 30.5 per 100 women-years after 2.2 years of median follow-up. Clinical factors such as HIV/AIDS (adjusted HR [aHR]: 11.9; 95% CI: 4.6, 30.4), advanced clinical stage (aHR: 2.7; 95% CI: 1.5, 4.7), and anemia at presentation (aHR: 1.8; 95% CI: 1.1, 3.0) were associated with a higher mortality risk, as were non-clinical factors such as age at diagnosis >50 years (aHR: 1.4; 95% CI: 1.0, 1.9) and family history of CCa (aHR: 3.5; 95%CI: 1.1, 11.1)ConclusionCCa has a high mortality rate in Nigeria. Incorporating these clinical and non-clinical factors into CCa management and control policies may improve women’s outcomes.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria

et al. 2023

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“…A total of 11 studies considered other measures of cervical cancer burden; five studies reported mortality globally including Africa ( 117 , 144 ), South Africa ( 129 ), Kenya ( 139 ) and Ethiopia ( 97 ). One cross-sectional study reported the population attributable fraction in a GLOBOCAN study ( 108 ) Two cross-sectional studies reported the disability-adjusted life years (DALYs) in Kenya ( 115 ) and for the SSA region ( 119 ).…”

Section: Resultsmentioning

confidence: 99%

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

Musekiwa

Moyo²,

Mohammed³

et al. 2022

Front. Public Health

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BackgroundCancer remains a major public health problem, especially in Sub-Saharan Africa (SSA) where the provision of health care is poor. This scoping review mapped evidence in the literature regarding the burden of cervical, breast and prostate cancers in SSA.MethodsWe conducted this scoping review using the Arksey and O'Malley framework, with five steps: identifying the research question; searching for relevant studies; selecting studies; charting the data; and collating, summarizing, and reporting the data. We performed all the steps independently and resolved disagreements through discussion. We used Endnote software to manage references and the Rayyan software to screen studies.ResultsWe found 138 studies that met our inclusion criteria from 2,751 studies identified through the electronic databases. The majority were retrospective studies of mostly registries and patient files (n = 77, 55.8%), followed by cross-sectional studies (n = 51, 36.9%). We included studies published from 1990 to 2021, with a sharp increase from 2010 to 2021. The quality of studies was overall satisfactory. Most studies were done in South Africa (n = 20) and Nigeria (n = 17). The majority were on cervical cancer (n = 93, 67.4%), followed by breast cancer (67, 48.6%) and the least were on prostate cancer (48, 34.8%). Concerning the burden of cancer, most reported prevalence and incidence. We also found a few studies investigating mortality, disability-adjusted life years (DALYs), and years of life lost (YLL).ConclusionsWe found many retrospective record review cross-sectional studies, mainly in South Africa and Nigeria, reporting the prevalence and incidence of cervical, breast and prostate cancer in SSA. There were a few systematic and scoping reviews. There is a scarcity of cervical, breast and prostate cancer burden studies in several SSA countries. The findings in this study can inform policy on improving the public health systems and therefore reduce cancer incidence and mortality in SSA.

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The trend of change in cervical tumor size and time to death of hospitalized patients in northwestern Ethiopia during 2018–2022: Retrospective study design

Aguade

Gashu²,

Jegnaw

2023

Health Science Reports

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Background and Aims: Cervical cancer is the fourth most common cause of cancerrelated death in the world. The objective of this study was to determine factors that affect the longitudinal change of tumor size and the time to death of outpat Methods: A retrospective follow-up study was carried out among 322 randomly selected patients with cervical cancer at the University of Gondar Referral Hospital from May 15, 2018 to May 15, 2022. Data were extracted from the patient's chart from all patients' data records. Kaplan-Meier estimator, log-rank test, the Cox proportional-hazard model, and the joint model for the two response variables simultaneously were used.Results: Among 322 outpatients with cervical cancer, 148 (46%) of them were human immunodeficiency virus (HIV) positive and 107 (33.3%) of them died. The results of joint and separate models show that there is an association between survival and the longitudinal data in the analysis; it indicates that there is a dependency between longitudinal terms of cervical tumor size and time-to-death events. A unit centimeter square rise in tumor size, corresponding to an exp (0.8502) = 2.34 times, significantly raised the mortality risk. Conclusion:The study showed that HIV, stage of cancer, treatment, weight, history of abortion, oral contraceptive use, smoking status, and visit time were statistically significant factors for the two outcomes jointly.Implications: As a result, adequate health services and adequate resource allocations are critical for cervical cancer control and prevention programs. Therefore, the government should provide adequate funding and well-trained health professionals to hospitals to sustain screening programs with appropriate coverage of cervical cancer patient treatments.

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Determinants of Mortality among Cervical Cancer Patients Attending in Tikur Anbessa Specialized Hospital, Ethiopia: Institutional-Based Retrospective Study

Cited by 6 publications

References 36 publications

Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria

Clinical and non-clinical determinants of cervical cancer mortality: A retrospective cohort study in Lagos, Nigeria

Mapping Evidence on the Burden of Breast, Cervical, and Prostate Cancers in Sub-Saharan Africa: A Scoping Review

The trend of change in cervical tumor size and time to death of hospitalized patients in northwestern Ethiopia during 2018–2022: Retrospective study design

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