Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis

Belay, Habtamu Gebrehana; Debebe, Getachew Arage; Ayele, Alemu Degu; Kassa, Bekalu Getnet; Mihretie, Gedefaye Nibret; Worke, Mulugeta Dile

doi:10.1007/s12519-022-00597-3

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…Finding that neonatal jaundice was common corroborates with a study carried out in Cape Coast Teaching Hospital in Ghana [39], and its association with neonatal sepsis is wellrecognized [15]. Though not typically a cause of death, severe neonatal jaundice can cause kernicterus, which is a risk factor for death and neurologic damage resulting in cerebral palsy [40,41]. ABO and Rhesus blood group incompatibility, G6PD deficiency, sepsis and low birth weight are the common causes of neonatal jaundice [15,42,43].…”

Section: Discussionsupporting

confidence: 79%

Trends in Neonatal Mortality at Princess Marie Louise Children’s Hospital, Accra, and the Newborn Strategic Plan: Implications for Reducing Mortality in Hospital and the Community

Tette,

Nartey,

Nyarko

et al. 2023

Children

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Background: In low and middle-income countries, close to half of the mortality in children under the age of five years occurs in neonates. Objectives: We examined the trend, medical conditions and factors associated with newborn deaths at the Princess Marie Louise Children’s Hospital (PML), Accra, from 2014 to 2017 (4 years). Methods: The study was a cross-sectional study. Data on age, sex, date of admission, date of discharge, cause of death and place of residence of these babies were obtained from the records department. This was transferred into an Access database and analyzed. Components of the Newborn Strategic Plan implemented at the hospital were described. Results: Neonatal sepsis, pneumonia and kernicterus were the major causes of death. Admissions increased and 5.4% of the neonates died, declining from 6.5% in 2014 to 4.2% in 2017 due to deliberate actions to reduce neonatal death. The highest mortality occurred in babies residing in an area more than 1 hour’s drive away from the hospital. Conclusion: Implementing the Newborn Strategic Plan was associated with a drop in mortality. A preponderance of community-acquired infections was observed. Thus, locality-specific interventions targeted at known determinants and implementing the newborn strategic plan are essential for reducing neonatal mortality.

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Section: Discussionsupporting

confidence: 79%

Trends in Neonatal Mortality at Princess Marie Louise Children’s Hospital, Accra, and the Newborn Strategic Plan: Implications for Reducing Mortality in Hospital and the Community

Tette,

Nartey,

Nyarko

et al. 2023

Children

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“…Neonatal hypoxia may cause liver injury, which interferes with the liver's ability to process bilirubin, increasing the incidence of neonatal jaundice. In the meta‐analysis by Belay et al., 37 neonatal asphyxia nearly quadrupled the likelihood of newborn jaundice. In a cohort study, Yu et al 38 .…”

Section: Discussionmentioning

confidence: 99%

“…the incidence of neonatal jaundice. In the meta-analysis by Belay et al,37 neonatal asphyxia nearly quadrupled the likelihood of newborn jaundice. In a cohort study, Yu et al…”

mentioning

confidence: 97%

Association of gestational hepatitis B virus infection and antiviral therapy with pregnancy outcomes: A retrospective study

Mao,

Jiang,

Cai

et al. 2024

Intl J Gynecology & Obste

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ObjectiveTo explore the relationships between gestational hepatitis B virus (HBV) infection, antiviral therapy, and pregnancy outcomes.MethodsWe retrospectively selected hepatitis B surface antigen (HBsAg)‐positive pregnant women hospitalized for delivery at Fujian Medical University Affiliated Hospital from October 1, 2016 to October 1, 2020. The control group included randomly selected healthy pregnant women hospitalized for delivery during the same time.ResultsOverall, 1115 participants were enrolled and grouped into control (n = 380) and HBsAg‐positive groups (n = 735), which were further divided into groups I (n = 407; low viral load), II (n = 207; high viral load without antiviral therapy), and III (n = 121; high viral load with antiviral therapy). Pregnant women with HBV were positively correlated with the incidence of intrahepatic cholestasis of pregnancy (ICP) (adjusted odds ratio [aOR] 5.1, 95% confidence interval [CI] 2.62–9.92, P < 0.001), neonatal jaundice (aOR 10.56, 95% CI 4.49–24.83, P < 0.001), and neonatal asphyxia (aOR 5.03, 95% CI 1.46–17.27, P = 0.01). Aspartate aminotransferase (AST) greater than the upper limit of normal (ULN) was an independent risk factor for increased ICP incidence (aOR 3.49, 95% CI 1.26–9.67, P = 0.019). Antiviral therapy considerably reduced HBV DNA and improved liver function. High viral load and antiviral therapy did not correlate significantly with adverse pregnancy outcomes (P < 0.05).ConclusionPregnant women with HBV have significantly elevated incidence of ICP, neonatal jaundice, and neonatal asphyxia not significantly correlated with viral load. AST greater than ULN independently increases the risk of ICP. Antiviral therapy effectively reduces viral replication and improves liver function without increasing the risk of adverse outcomes.

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“…Oppong et al, 2019), 34.2% in Nigeria(Olatubi et al, 2019), and 31% in Ethiopia(Belay et al, 2022). On the contrary, the study ofGirma (2020) found a low prevalence rate of 13.3% in Ethiopia and nearly half (44.3%) of 210 neonates were diagnosed with neonatal jaundice in Rwanda With regards to the neonatal factors associated with NNJ, the prevalence of neonatal jaundice was very common among neonates who were underweight as all neonates with low birth weight (100%) in the study had neonatal jaundice.…”

mentioning

confidence: 96%

Prevalence and Factors associated with Neonatal Jaundice in Northern Ghana

Nartey

2024

Preprint

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Background Neonatal Jaundice (NNJ) is one of the major contributors of neonatal mortality worldwide with Sub-Saharan African being one of the greatest contributors. As a result, it is considered a public health concern. The long-term effects of NNJ can be dire, however, these can be minimised or prevented through appropriate screening and treatment. This study examined the prevalence and factors associated with NNJ in Northern Ghana. Methods This study used a quantitative approach with a cross-sectional study design to select 330 mothers and their neonates who were on admission in the Neonatal Intensive Care Units of four referral hospitals at the time of the study. Both descriptive and inferential data analysis was done using IBM SPSS Statistics software (version 26). Results Out of the total number of 330 neonates included in the study, 33.3% of them were diagnosed of NNJ. Factors such as antenatal attendance, mothers having a previous baby diagnosed with NNJ, delivery mode, parity and maternal blood group were strongly related to a neonate being diagnosed od NNJ Conclusion This study revealed that the prevalence of NNJ in Northern Ghana is 33.3%. The study has revealed the risk factors for NNJ. It is therefore important that health practitioners take into consideration these risk factors and the planning of maternal and child health care services.

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Determinants of neonatal jaundice in Ethiopia: a systematic review and meta-analysis

Cited by 7 publications

References 33 publications

Trends in Neonatal Mortality at Princess Marie Louise Children’s Hospital, Accra, and the Newborn Strategic Plan: Implications for Reducing Mortality in Hospital and the Community

Trends in Neonatal Mortality at Princess Marie Louise Children’s Hospital, Accra, and the Newborn Strategic Plan: Implications for Reducing Mortality in Hospital and the Community

Association of gestational hepatitis B virus infection and antiviral therapy with pregnancy outcomes: A retrospective study

Prevalence and Factors associated with Neonatal Jaundice in Northern Ghana

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