Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Dries, Michiel A. van den; Pronk, Anjoeka; Guxens, Mònica; Spaan, Suzanne; Voortman, Trudy; Jaddoe, Vincent W. V.; Jusko, Todd A.; Longnecker, Matthew P.; Tiemeier, Henning

doi:10.1016/j.ijheh.2018.01.013

Cited by 58 publications

(52 citation statements)

References 74 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regard to the biological plausibility of our findings, we found that lean women have higher DAP metabolites (

median:

vs.

) than overweight/obese women, which was consistent with the results from previous studies ( Llop et al. 2017 ; Van den Dries et al. 2018 ).…”

Section: Discussionsupporting

confidence: 92%

“…In regard to the biological plausibility of our findings, we found that lean women have higher DAP metabolites (R 4 DAP median: 243:84 nmol=g vs. 219:15 nmol=g) than overweight/ obese women, which was consistent with the results from previous studies (Llop et al 2017;Van den Dries et al 2018). We could infer that lean women tend to have a healthier lifestyle, with more FV in their diet, which may result in higher DAP concentrations.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

BACKGROUND: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. OBJECTIVES: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. METHODS: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. RESULTS: Compared with women in the lowest quartile (Q 1) of individual DEP and R 4 DAP (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile (Q 4) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant (p-trends <0:05). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, E 2 trigger levels, and endometrial wall thickness. CONCLUSION: Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF.

show abstract

“…In regard to the biological plausibility of our findings, we found that lean women have higher DAP metabolites (

median:

vs.

) than overweight/obese women, which was consistent with the results from previous studies ( Llop et al. 2017 ; Van den Dries et al. 2018 ).…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…In addition, maternal dietary intake in the first trimester was assessed using a modified version of a validated semiquantitative food frequency questionnaire (FFQ), and the 293 food items were reduced to 24 predefined food groups (e.g., meat, grains, vegetables, fruits) according to the European Prospective Investigation into Cancer and Nutrition (EPIC)–soft classification, based on origin, culinary usage, and nutrient profiles (Steenweg-de Graaff et al. 2012; van den Dries et al. 2018).…”

Section: Methodsmentioning

confidence: 99%

“…Third, models truncating the bottom and top 3% of exposure and child nonverbal IQ values were fit to test data robustness. Fourth, the primary models were adjusted for fruit and vegetable intake (van den Dries et al. 2018).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years

Jusko

Dries

Pronk

et al. 2019

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and child cognition. Objectives: Our objective was to determine whether maternal urinary concentrations of OP pesticide metabolites are inversely associated with child nonverbal IQ at 6 y of age and to examine potential effect measure modification by the PON1 gene. Methods: Data came from 708 mother–child pairs participating in the Generation R Study. Maternal urine concentrations of six dialkylphosphates (DAPs), collected at , 18–25, and of gestation, were determined. Child nonverbal IQ was measured at 6 y of age using the Mosaics and Categories subtests from the Snijders-Oomen Nonverbal Intelligence Test–Revised. PON1 was determined in cord blood for 474 infants. Multiple linear regression models were fit to estimate the DAP–IQ associations and PON1 interactions. Results: Overall, associations between child nonverbal IQ and maternal DAP concentrations were small and imprecise, and these associations were inconsistent across urine sampling periods. However, for a 10-fold difference in total DAP concentration for the of gestation samples, adjusted child nonverbal IQ was 3.9 points lower (95% CI: , ). Heterogeneity in the DAP–IQ association by PON1 gene allele status was not observed ( ). Conclusions: Consistent evidence of an association between higher maternal urinary DAP concentrations and lower child IQ scores at 6 y of age was not observed. There was some evidence for an inverse relation of child nonverbal IQ and late pregnancy urinary DAPs, but the estimated association was imprecise. https://doi.org/10.1289/EHP3024

show abstract

Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

Kori

Mandrah

Hasan

et al. 2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Earlier, we reported that chronic exposure to pesticides causes a reduction in the acetylcholinesterase activity and hematological and biochemical alterations in agriculture workers. In continuation with that, the present study aimed to investigate the pesticide‐induced neurochemical imbalance and its association with behavior alterations in agricultural workers. A significant increase in depressive symptoms, assessed by the Beck Depression Inventory‐II was observed in pesticide exposed workers as compared to the unexposed. A decrease in the level of dopamine in plasma and levels of dopamine, 3,4‐dihydroxyphenylacetic acid, homovanillic acids, norepinephrine, serotonin, and hydroxyindoleacetic acid in urine was also observed. An increase in the levels of MAO‐A and MAO‐B has also been observed in these individuals. The decreased levels of neurotransmitters in the blood and urine have been linked with increased levels of MAO and pesticide residues in plasma and urine. Furthermore, these changes were associated with a higher incidence of depression in agricultural workers.

show abstract

Determinants of organophosphate pesticide exposure in pregnant women: A population-based cohort study in the Netherlands

Cited by 58 publications

References 74 publications

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years

Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers

Contact Info

Product

Resources

About