“…Interventions to improve osteoporosis medication persistence and adherence have evaluated effects of different regimens, patient monitoring, and education. Several studies (8,19,23,24) show that oral weekly bisphosphonates may improve adherence versus daily regimen; however other studies pointed out that, even for the patients taking bisphosphonates dosed weekly, persistence and adherence were suboptimal. Although it is possible that a less frequently dosed drugs might further improve adherence (8), the literature suggests that enhancing Patients on treatment % medication adherence is much more complicated than changes in frequency of dosing (25)(26)(27)(28).…”