Determinants of Plasma Concentrations of Perfluorooctanesulfonate and Brominated Organic Compounds in Nunavik Inuit Adults (Canada)

Dallaire, Renée; Ayotte, Pierre; Pereg, Daria; Déry, Steve; Dumas, Pierre; Langlois, Éric; Dewailly, Éric

doi:10.1021/es9001604

Cited by 82 publications

(48 citation statements)

References 50 publications

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“…In a study of BFRs in Canadian Inuit from Nunavik, Quebec, plasma samples were found to contain a geometric mean TBP concentration of 58 ng/L or approximately 9.4 ng/g lw [127]. These concentrations were somewhat higher than those of BDE-47 and -153 and in the same range as those found in Norway.…”

Section: Humansmentioning

confidence: 88%

Emerging Brominated Flame Retardants in the Environment

Wit

Kierkegaard

Ricklund

et al. 2010

The Handbook of Environmental Chemistry

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A number of new brominated flame retardants (BFRs) are being found in the environment but the amount of data is still very small. The best studied emerging BFRs are 1,2-bis(2,4,6-tribromophenoxy)ethane and decabromodiphenyl ethane, with some data for hexabromobenzene, pentabromoethylbenzene, pentabromotoluene, tetrabromobisphenol A derivatives, bis(2-ethylhexyl) tetrabromophthalate, 2-ethylhexyltetrabromobenzoate, 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane, and 2,4,6-tribromophenol. Very little data are available for 2,4,6-tribromophenyl allyl ether, 2,3-dibromopropyl-2,4,6-tribromophenyl ether, hexachlorocyclopentadienyldibromocyclooctane, tris(2,3-dibromopropyl) isocyanurate, tetrabromophthalic anhydride, 1,2,5,6-tetrabromocyclooctane, and octabromo-1,3,3-trimethyl-1-phenylindane. Indoor air concentrations are generally higher than outdoor air concentrations, indicating emissions from flame-retarded products. Their presence in indoor air and dust indicates possible human exposure from this pathway, but there are little human data available to determine this. The presence of several of these BFRs in fish, birds, and mammals indicates that they are bioavailable and can be absorbed and bioaccumulated. Their presence in outdoor air and in the Arctic indicates that several are capable of long range atmospheric transport. More data on these new BFRs are needed in order to determine if they pose unacceptable risks to the environment and to human health.

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Section: Humansmentioning

confidence: 88%

Emerging Brominated Flame Retardants in the Environment

Wit

Kierkegaard

Ricklund

et al. 2010

The Handbook of Environmental Chemistry

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“…BFRs were also evaluated in Norwegian individuals working in electronics dismantling facilities, where 2,4,6-TBP was measured in plasma ranging from 0.17 to 81 ng/g lipid 17 . In a study measuring BFRs in a Canadian Inuit population from Nunavik, Quebec, plasma samples contained a geometric mean 2,4,6-TBP concentration of 9.4 μg/kg lipid, however, these concentrations were not correlated with PBDE concentrations 18 . Finally, Qiu et al measured mean 2,4,6-TBP concentrations of 5.6 ng/g lipid in fetal plasma and 0.8 ng/g lipid in maternal plasma 19 .…”

Section: Introductionmentioning

confidence: 94%

Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues

Leonetti

Butt

Hoffman

et al. 2016

Environment International

100

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Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010–2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09 ng/g lipid (range: 0.12–141 ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4 ng/g lipid (range:1.31–316 ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs=−0.16; p=0.10 and rs=−0.17; p=0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.

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“…Concentrations and distributions of PBDEs in the environment were well documented in North America (Dallaire et al 2009), Europe (Jaraczewska et al 2006, Roosens et al 2010, Australia (Besis and Samara 2012) and Asia (Hong et al 2010). Yet, there is little information about the exposure levels of PBDEs in Chinese lakes (Zhou et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Polybrominated diphenyl ethers (PBDEs) in sediment and fish tissues from Lake Chaohu, central eastern China

Yang¹,

Fu²,

Man³

et al. 2015

Archives of Environmental Protection

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Polybrominated diphenyl ethers (PBDEs) levels in environmental media have increased over the last 20-25 years in the world. In aquatic environments PBDEs were found to be accumulated along food chain and Endocrine disruptors toxicity. In this study PBDEs were investigated in sediment and fi sh tissues from Lake Chaohu in central eastern China. There were 10 PBDEs congeners detected out of all 41 PBDEs. BDE-47 was of the highest with 5.17 ng/g in sediment and 58.47 ng/g in fi sh. PBDEs were evenly distributed across the surface sediment in the whole lake. It implied that the main source of PBDEs may not be an infl ow river like Nanfei. Tissue distribution patterns of PBDEs in four fi sh species were in the order of BDE-47 > BDE-99 > BDE-100 > BDE-66 > BDE-138 > BDE-183 > BDE-154 > BDE-153. Octa-and deca-BDEs were below the detection limit. The concentrations of all PBDE congeners were higher in gills, livers, and kidneys than those in muscles and adipose tissue. Furthermore, PBDEs in different tissues had some different distribution patterns with fi sh size. Those discrepancies appeared to be correlated with the PBDEs pollution fl uxes varying with the change of the year and their metabolism divergences in fi sh tissues.

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Determinants of Plasma Concentrations of Perfluorooctanesulfonate and Brominated Organic Compounds in Nunavik Inuit Adults (Canada)

Cited by 82 publications

References 50 publications

Emerging Brominated Flame Retardants in the Environment

Emerging Brominated Flame Retardants in the Environment

Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues

Polybrominated diphenyl ethers (PBDEs) in sediment and fish tissues from Lake Chaohu, central eastern China

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