Determinants of platelet count are different in patients with compensated and decompensated cirrhosis

Latorre, Raquel García; Vaquero, Javier; Rincón, Diego; Puerto, Marta; Ponce, María D.; Sarnago, Fernando; Matamoros, Jose A.; Enrique, Rafael; Elı́zaga, Jaime; Bañares, Rafael; Ripoll, Cristina

doi:10.1111/liv.12908

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…In compensated liver cirrhosis, spleen size correlated with platelet counts 16,17 and was directly proportional to the phagocytic activity of the spleen 18 ; therefore, we used spleen size to evaluate the degree of hypersplenism. In the current study, spleen volume significantly decreased approximately 1 year after starting antiviral therapy, suggesting that the degree of hypersplenism decreased 1 year after the start of antiviral therapy.…”

Section: Discussionmentioning

confidence: 99%

Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection

Ishizu

Ishigami

Hayashi

et al. 2019

Hepatology Research

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The cause of thrombocytopenia in patients with chronic hepatitis C virus (HCV) infection is multifactorial: hypersplenism, decreased thrombopoietin levels, and myelosuppression induced by HCV. Platelet counts increase after eradication of HCV; however, this mechanism is not fully understood. Therefore, the aim of this study was to determine the influence of these three factors on platelet counts. Methods:We retrospectively analyzed data from 109 HCVinfected patients with platelet counts ≤150 × 10 3 /μL who achieved viral eradication using interferon-free anti-HCV therapy. Changes in hematological parameters, thrombopoietin levels, HCV titers, and spleen volumes, and the correlations among them were evaluated.Results: HCV RNA levels significantly decreased at 4 weeks after initiating antiviral therapy. Platelet counts rapidly increased at 4 weeks from baseline (120 ± 35 vs. 106 ± 28 × 10 3 /μL, P < 0.001), and remained at a plateau until 48 weeks after initiating antiviral therapy. Neutrophil counts showed the same pattern. Spleen volume was evaluated in 32 patients and, among them, it decreased in 21 patients, but remained unchanged in seven and increased in four. In addition to patients with decreased spleen volume, patients with unchanged spleen volume showed marginally increased platelet counts. Thrombopoietin levels did not correlate with platelet counts. Conclusions:Platelet counts increased at 4 weeks after starting anti-HCV treatment. Our results suggest that this rapid change was possibly caused by improvement of hypersplenism and HCV-induced myelosuppression resulting from anti-HCV therapy.

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Section: Discussionmentioning

confidence: 99%

Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection

Ishizu

Ishigami

Hayashi

et al. 2019

Hepatology Research

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“…We found that the influences of etiology and sex were only moderate but that of severity was marked. Indeed, VNT prevalence, platelets and LSM are strongly related to liver severity 13 . This results in the reduction of the performance of NITs in severe CLD.…”

Section: Clinical Applicationmentioning

confidence: 99%

Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

Berger

Ravaioli

Farcau³

et al. 2021

Clinical Gastroenterology and Hepatology

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“…BMSC transplantation, as a new technology for repairing regenerated damaged organs, has become a research hotspot for stem cell transplantation due to the advantages of convenient collection, low rejection, safety and reliability, and low cost[ 23 , 24 ]. BMSCs can replace damaged hepatocytes by inducing differentiation into hepatocytes in severe liver disease, improve function of the damaged liver, and bring new hope for the treatment of cirrhosis[ 25 , 26 ]. In our previous study, ABMI for patients with DLC and acquired immunodeficiency syndrome significantly prolonged survival.…”

Section: Discussionmentioning

confidence: 99%

Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study

Liu,

Cheng,

Lang

et al. 2023

World J Gastrointest Surg

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Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures (e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim.

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Determinants of platelet count are different in patients with compensated and decompensated cirrhosis

Cited by 11 publications

References 37 publications

Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection

Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection

Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment

Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study

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