Determinants of platelet count in humans

Daly, Mary E.

doi:10.3324/haematol.2010.035287

Cited by 112 publications

(84 citation statements)

References 21 publications

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“…Thrombopoietin, a hormone that regulates production of platelets, has been found to peak shortly after birth and gradually decline to adult concentrations (26 ), which could explain the higher platelet counts observed in early childhood. Although it is not clear why there are sex differences during adolescence and adulthood, they may be related to hormonal changes and genetic variability (27 ). Interestingly, Biino et al found that thrombocytopenia is more common in men than women and tends to be more frequent among the elderly (25 ), consistent with our findings.…”

Section: Discussionsupporting

confidence: 82%

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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BACKGROUND In a collaboration between the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) and the Canadian Health Measures Survey (CHMS), we determined reference value distributions using an a priori approach and created a comprehensive database of age- and sex-stratified reference intervals for clinically relevant hematologic parameters in a large household population of children and adults. METHODS The CHMS collected data and blood samples from 11 999 respondents aged 3–79 years. Hematology markers were measured with either the Beckman Coulter HmX or Siemens Sysmex CA-500 Series analyzers. After applying exclusion criteria and removing outliers, we determined statistically relevant age and sex partitions and calculated reference intervals, including 90% CIs, according to CSLI C28-A3 guidelines. RESULTS Hematology marker values showed dynamic changes from childhood into adulthood as well as between sexes, necessitating distinct partitions throughout life. Most age partitions were necessary during childhood, reflecting the hematologic changes that occur during growth and development. Hemoglobin, red blood cell count, hematocrit, and indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) increased with age, but females had lower hemoglobin and hematocrit starting at puberty. Platelet count gradually decreased with age and required multiple sex partitions during adolescence and adulthood. White blood cell count remained relatively constant over life, whereas fibrinogen increased slightly, requiring distinct age and sex partitions. CONCLUSIONS The robust dataset generated in this study has allowed observation of dynamic biological profiles of several hematology markers and the establishment of comprehensive age- and sex-specific reference intervals that may contribute to accurate monitoring of pediatric, adult, and geriatric patients.

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Section: Discussionsupporting

confidence: 82%

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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“…These two transit times reflect the state of cell maturation and the senescence systems. The average life span of a reticulated PLT is about 1 day in dogs (8) and that for the mature PLT is about 10 days in humans (9). Final estimated transit time parameters (Table 2) are in good agreement with these values in infants not receiving transfusions.…”

Section: Discussionsupporting

confidence: 75%

Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates

Kulshrestha

Sola‐Visner

Widness

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Kulshrestha M, Sola-Visner M, Widness JA, Veng-Pedersen P, Mager DE. Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates. Am J Physiol Heart Circ Physiol 308: H68 -H73, 2015. First published October 31, 2014 doi:10.1152/ajpheart.00528.2013.-Neonatal thrombocytopenia affects 22-35% of all neonates admitted to neonatal intensive care units. The purpose of this study was to develop a mathematical model for characterizing platelet (PLT) kinetics in thrombocytopenic preterm neonates. Immature PLT fraction (IPF) and PLT counts were measured for up to 35 days after birth in 27 very low birth weight preterm neonates. PLT transfusions were administered to 8 of the 27 (24%) subjects. The final model included a series of four transit compartments to mimic the production and survival of IPF and PLT. Model parameters were estimated using nonlinear mixed effects modeling with the maximum likelihood expectation maximization algorithm. The model adequately captured the diverse phenotypes expressed by individual subject profiles. Typical population survival values for IPF and PLT life spans in nonthrombocytopenic patients were estimated at 0.912 and 10.7 days, respectively. These values were significantly shorter in thrombocytopenic subjects, 0.429 and 2.56 days, respectively. The model was also used to evaluate the influence of growth and laboratory phlebotomy loss on the time course of IPF and PLT counts. Whereas incorporating body weight was essential to correct for expanding blood volume due to growth, phlebotomy loss, a possible covariate, did not significantly influence PLT kinetics. This study provides a platform for identifying potential covariates that influence the interindividual variability in model parameters regulating IPF and PLT kinetics and for evaluating future pharmacological therapies for treating thrombocytopenic neonates. neonatal thrombocytopenia; immature platelet fraction; platelets; transit compartment model NEONATAL THROMBOCYTOPENIA is a common hematological disorder, and ϳ22-35% of all neonates admitted to the neonatal intensive care unit suffer from this condition (22,27). Premature very low birth weight (VLBW, Ͻ1,500 g at birth) neonates are more often affected, as the incidence of thrombocytopenia is inversely proportional to gestational age. Traditionally, the definition of thrombocytopenia in neonates of all gestational ages is the same as in adults, namely a platelet (PLT) count of Ͻ150 ϫ 10 3 /l based on fetuses in the second trimester having PLT counts within the normal adult range (13).The underlying general mechanisms responsible for neonatal thrombocytopenia are similar to adults, namely, increased PLT destruction, decreased PLT production, PLT sequestration, or a combination of these processes (27). However, it is more difficult to identify causes of neonatal thrombocytopenia as the diagnosis can be challenging owing to the dynamic nature of newborn development and technical difficulties associated with performing certain diagnostic tests i...

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“…3,7 The normal range of platelet counts in adults is 150,000 -400,000/µL. Higher platelet counts are observed in females than in males 8 . Approximately 40 % of patients with severe sepsis have platelet counts less than 80,000/mm 3 .…”

Section: Introductionmentioning

confidence: 98%

Effect of severe sepsis on platelet count and their indices

Güçlü¹,

Durmaz²,

Karabay³

2013

Afr H. Sci.

122

134

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Background: Sepsis is a major disease affecting almost all organs and systems. Objectives: To examine platelet count and indices (mean platelet volume (MPV) and platelet distribution width (PDW)) in severe sepsis. Methods: Patients with criteria for sepsis at a first examination by an Infectious Diseases specialist were selected. Consecutive patients who were admitted to the out-patient clinic and who were not diagnosed with any infectious disease were selected as the control group. Results: A total of 145 patients with sepsis and 143 patients as a control group were included in the study. MPV and PDW were significantly differentbetween sepsis patients and control group (P<0.05). Platelet count in sepsis patients was lower than control group but the difference was not significant. PDW was the unique significantly different parameter between survivors and non-survivors (p=0.001). Conclusions: Platelet indices are important laboratory findings in the diagnosis of sepsis and severe sepsis. Severe sepsis patients who have greater than 18 % PDW levels have a higher risk of death. Therefore, PDW, which is part of an inexpensive, easily accessible and routinely performed test for almost all patients admitted to health facilities may be used for predicting mortality.

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Determinants of platelet count in humans

Cited by 112 publications

References 21 publications

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates

Effect of severe sepsis on platelet count and their indices

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